Clinical implication of elevated serum creatine kinase in rotavirus gastroenteritis

Abstract

Background: Rotavirus (RV) is the leading agent of acute gastroenteritis in children under five years old, especially in children of 6~24 months. RV can lead to serious complications or even death. RV can cause a heavy burden of disease particularly in developing countries such as China. To prevent or reduce rotavirus diarrhea (RVD) and RV infection related diseases, damages or complications in children is an important task of public health.

RV can also cause extraintestinal damage and complications. The finding of elevated CK-MB has been reported in a couple of Chinese literatures, but the epidemiology and the potential implication of this phenomenon remain poorly understood.

Objective: 1. To study the prevalence of elevated serum CK-MB level among children hospitalized with rotavirus gastroenteritis in Guangzhou. 2. To examine factors associated with an elevated CK-MB level 3. To examine the clinical implication of elevated serum CK-MB level with different clinical symptomatology, severity, and disease outcome of rotavirus gastroenteritis in children.

Methods: Aretrospective analysis of hospital records had carried out in Guangzhou Women and Children’s Medical Centre (GZWCMC), China. Hospital records during the period from 1 January 2011 to 31 December 2011 of inpatients from GZWCMC were screened and all inpatients with a diagnosis of rotavirus gastroenteritis in GZWCMC were recruited.

Result and conclusion: Our study included418 cases of rotavirus infection hospitalized in GZWCMC in Guangdong in 2011, we found elevation of CK-MB a common phenomenon among patients of RV gastroenteritis, and identified a number of risk factors for elevated CK-MB level. These included patients of aged between 6-24 months, cases occurring in autumn or winter, patients coming from low income families, had never been breast-fed, or having dehydration, vomiting, malnutrition, fever, or having an abnormal blood gas and electrolyte. The elevated CK-MB level was positively associated with a higher occurrence of complications, a longer duration of hospitalization, and higher hospital cost per day.