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Article: Highly conserved protective epitopes on influenza B viruses

TitleHighly conserved protective epitopes on influenza B viruses
Authors
Dreyfus, CLaursen, NSKwaks, TZuijdgeest, DKhayat, REkiert, DCLee, JHMetlagel, ZBujny, MVJongeneelen, MVan Der Vlugt, RLamrani, MKorse, HJWMGeelen, ESahin, ÖSieuwerts, MBrakenhoff, JPJVogels, RLi, OTWPoon, LLMPeiris, MKoudstaal, WWard, ABWilson, IAGoudsmit, JFriesen, RHE
Issue Date2012
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 2012, v. 337 n. 6100, p. 1343-1348 How to Cite?
DOI: http://dx.doi.org/10.1126/science.1222908
AbstractIdentification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a substantial part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses.
Persistent Identifierhttp://hdl.handle.net/10722/179841
ISSN
0036-8075
2023 Impact Factor: 44.7
2023 SCImago Journal Rankings: 11.902
ISI Accession Number ID
WOS:000308705000043
References
References in Scopus
Grants
Control of Pandemic and Inter-pandemic Influenza

 

DC FieldValueLanguage
dc.contributor.authorDreyfus, Cen_US
dc.contributor.authorLaursen, NSen_US
dc.contributor.authorKwaks, Ten_US
dc.contributor.authorZuijdgeest, Den_US
dc.contributor.authorKhayat, Ren_US
dc.contributor.authorEkiert, DCen_US
dc.contributor.authorLee, JHen_US
dc.contributor.authorMetlagel, Zen_US
dc.contributor.authorBujny, MVen_US
dc.contributor.authorJongeneelen, Men_US
dc.contributor.authorVan Der Vlugt, Ren_US
dc.contributor.authorLamrani, Men_US
dc.contributor.authorKorse, HJWMen_US
dc.contributor.authorGeelen, Een_US
dc.contributor.authorSahin, Öen_US
dc.contributor.authorSieuwerts, Men_US
dc.contributor.authorBrakenhoff, JPJen_US
dc.contributor.authorVogels, Ren_US
dc.contributor.authorLi, OTWen_US
dc.contributor.authorPoon, LLMen_US
dc.contributor.authorPeiris, Men_US
dc.contributor.authorKoudstaal, Wen_US
dc.contributor.authorWard, ABen_US
dc.contributor.authorWilson, IAen_US
dc.contributor.authorGoudsmit, Jen_US
dc.contributor.authorFriesen, RHEen_US
dc.date.accessioned2012-12-19T10:05:23Z-
dc.date.available2012-12-19T10:05:23Z-
dc.date.issued2012en_US
dc.identifier.citationScience, 2012, v. 337 n. 6100, p. 1343-1348en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/10722/179841-
dc.description.abstractIdentification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a substantial part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses.en_US
dc.languageengen_US
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.orgen_US
dc.relation.ispartofScienceen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Monoclonal - Chemistry - Immunologyen_US
dc.subject.meshAntibodies, Neutralizing - Chemistry - Immunologyen_US
dc.subject.meshConserved Sequenceen_US
dc.subject.meshHemagglutinin Glycoproteins, Influenza Virus - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunodominant Epitopes - Chemistry - Immunologyen_US
dc.subject.meshInfluenza B Virus - Immunologyen_US
dc.subject.meshInfluenza Vaccines - Immunologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNeutralization Testsen_US
dc.subject.meshOrthomyxoviridae Infections - Prevention & Controlen_US
dc.subject.meshProtein Conformationen_US
dc.titleHighly conserved protective epitopes on influenza B virusesen_US
dc.typeArticleen_US
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_US
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_US
dc.identifier.authorityPoon, LLM=rp00484en_US
dc.identifier.authorityPeiris, M=rp00410en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1126/science.1222908en_US
dc.identifier.pmid22878502-
dc.identifier.scopuseid_2-s2.0-84866122029en_US
dc.identifier.hkuros226053-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84866122029&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume337en_US
dc.identifier.issue6100en_US
dc.identifier.spage1343en_US
dc.identifier.epage1348en_US
dc.identifier.isiWOS:000308705000043-
dc.publisher.placeUnited Statesen_US
dc.identifier.f1000717956527-
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridDreyfus, C=53163561100en_US
dc.identifier.scopusauthoridLaursen, NS=55329426800en_US
dc.identifier.scopusauthoridKwaks, T=6505918270en_US
dc.identifier.scopusauthoridZuijdgeest, D=8739427900en_US
dc.identifier.scopusauthoridKhayat, R=13610998000en_US
dc.identifier.scopusauthoridEkiert, DC=6504355759en_US
dc.identifier.scopusauthoridLee, JH=55312618600en_US
dc.identifier.scopusauthoridMetlagel, Z=15127564500en_US
dc.identifier.scopusauthoridBujny, MV=55329989300en_US
dc.identifier.scopusauthoridJongeneelen, M=8609959300en_US
dc.identifier.scopusauthoridVan Der Vlugt, R=14059283000en_US
dc.identifier.scopusauthoridLamrani, M=55329472200en_US
dc.identifier.scopusauthoridKorse, HJWM=49861388800en_US
dc.identifier.scopusauthoridGeelen, E=6602562335en_US
dc.identifier.scopusauthoridSahin, Ö=55329867300en_US
dc.identifier.scopusauthoridSieuwerts, M=14059023000en_US
dc.identifier.scopusauthoridBrakenhoff, JPJ=55406091200en_US
dc.identifier.scopusauthoridVogels, R=7005841896en_US
dc.identifier.scopusauthoridLi, OTW=55329439400en_US
dc.identifier.scopusauthoridPoon, LLM=7005441747en_US
dc.identifier.scopusauthoridPeiris, M=7005486823en_US
dc.identifier.scopusauthoridKoudstaal, W=6508125014en_US
dc.identifier.scopusauthoridWard, AB=55236614700en_US
dc.identifier.scopusauthoridWilson, IA=7401743864en_US
dc.identifier.scopusauthoridGoudsmit, J=35374719700en_US
dc.identifier.scopusauthoridFriesen, RHE=26648237000en_US
dc.identifier.citeulike11272752-
dc.identifier.issnl0036-8075-

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