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- Publisher Website: 10.1016/S0140-6736(00)03237-2
- Scopus: eid_2-s2.0-0034715975
- PMID: 11117917
- WOS: WOS:000165545700016
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Article: Prenatal detection of fetal Down's syndrome from maternal plasma
Title | Prenatal detection of fetal Down's syndrome from maternal plasma |
---|---|
Authors | |
Issue Date | 2000 |
Publisher | The Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet |
Citation | Lancet, 2000, v. 356 n. 9244, p. 1819-1820 How to Cite? |
Abstract | Fetal DNA is present in maternal plasma, and a proportion of such DNA is seen in intact fetal cells. We investigated the use of fluorescence in-situ hybridisation (FISH) techniques on maternal plasma samples. In plasma samples obtained from three women carrying fetuses affected by trisomy 21 (Down's syndrome), we identified fetal cells with three chromosome-21 signals. These results show the feasibility of non-invasive detection of fetal chromosomal aneuploidy by maternal plasma analysis. |
Persistent Identifier | http://hdl.handle.net/10722/179767 |
ISSN | 2023 Impact Factor: 98.4 2023 SCImago Journal Rankings: 12.113 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Poon, LLM | en_US |
dc.contributor.author | Leung, TN | en_US |
dc.contributor.author | Lau, TK | en_US |
dc.contributor.author | Lo, YMD | en_US |
dc.date.accessioned | 2012-12-19T10:04:26Z | - |
dc.date.available | 2012-12-19T10:04:26Z | - |
dc.date.issued | 2000 | en_US |
dc.identifier.citation | Lancet, 2000, v. 356 n. 9244, p. 1819-1820 | en_US |
dc.identifier.issn | 0140-6736 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179767 | - |
dc.description.abstract | Fetal DNA is present in maternal plasma, and a proportion of such DNA is seen in intact fetal cells. We investigated the use of fluorescence in-situ hybridisation (FISH) techniques on maternal plasma samples. In plasma samples obtained from three women carrying fetuses affected by trisomy 21 (Down's syndrome), we identified fetal cells with three chromosome-21 signals. These results show the feasibility of non-invasive detection of fetal chromosomal aneuploidy by maternal plasma analysis. | en_US |
dc.language | eng | en_US |
dc.publisher | The Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet | en_US |
dc.relation.ispartof | Lancet | en_US |
dc.subject.mesh | Down Syndrome - Diagnosis - Embryology | en_US |
dc.subject.mesh | Feasibility Studies | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fetal Diseases - Diagnosis | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | In Situ Hybridization, Fluorescence | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Prenatal Diagnosis | en_US |
dc.title | Prenatal detection of fetal Down's syndrome from maternal plasma | en_US |
dc.type | Article | en_US |
dc.identifier.email | Poon, LLM: llmpoon@hkucc.hku.hk | en_US |
dc.identifier.authority | Poon, LLM=rp00484 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0140-6736(00)03237-2 | - |
dc.identifier.pmid | 11117917 | - |
dc.identifier.scopus | eid_2-s2.0-0034715975 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034715975&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 356 | en_US |
dc.identifier.issue | 9244 | en_US |
dc.identifier.spage | 1819 | en_US |
dc.identifier.epage | 1820 | en_US |
dc.identifier.isi | WOS:000165545700016 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Poon, LLM=7005441747 | en_US |
dc.identifier.scopusauthorid | Leung, TN=7202110927 | en_US |
dc.identifier.scopusauthorid | Lau, TK=24491963900 | en_US |
dc.identifier.scopusauthorid | Lo, YMD=7401935391 | en_US |
dc.identifier.issnl | 0140-6736 | - |