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- Publisher Website: 10.1196/annals.1317.047
- Scopus: eid_2-s2.0-33746459319
- PMID: 16888194
- WOS: WOS:000240364200051
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Conference Paper: Localization of small heterodimer partner (SHP) and secretin in mouse duodenal cells
Title | Localization of small heterodimer partner (SHP) and secretin in mouse duodenal cells |
---|---|
Authors | |
Keywords | NeuroD Secretin Small heterodimer partner |
Issue Date | 2006 |
Publisher | Wiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1 |
Citation | Annals Of The New York Academy Of Sciences, 2006, v. 1070, p. 371-375 How to Cite? |
Abstract | Previous studies have demonstrated the transcriptional repressive property of the atypical nuclear receptor, small heterodimer partner (SHP), on NeuroD. NeuroD is a basic helix-loop-helix transcription factor that has also been shown to be important in modulating secretin gene expression. The present study revealed the activation of the human secretin core promoter by overexpressing NeuroD, and the localization of SHP and secretin-producing cells in mouse duodenal epithelium by immunohistochemical stainings. These results indicated that SHP and secretin are potentially co-expressed and lead us to propose a novel regulatory pathway, in which SHP represses NeuroD's positive regulatory activity on secretin gene. © 2006 New York Academy of Sciences. |
Persistent Identifier | http://hdl.handle.net/10722/179590 |
ISSN | 2023 Impact Factor: 4.1 2023 SCImago Journal Rankings: 1.416 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lam, IPY | en_US |
dc.contributor.author | Lee, LTO | en_US |
dc.contributor.author | Choi, HS | en_US |
dc.contributor.author | Chow, BKC | en_US |
dc.date.accessioned | 2012-12-19T10:00:03Z | - |
dc.date.available | 2012-12-19T10:00:03Z | - |
dc.date.issued | 2006 | en_US |
dc.identifier.citation | Annals Of The New York Academy Of Sciences, 2006, v. 1070, p. 371-375 | en_US |
dc.identifier.issn | 0077-8923 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179590 | - |
dc.description.abstract | Previous studies have demonstrated the transcriptional repressive property of the atypical nuclear receptor, small heterodimer partner (SHP), on NeuroD. NeuroD is a basic helix-loop-helix transcription factor that has also been shown to be important in modulating secretin gene expression. The present study revealed the activation of the human secretin core promoter by overexpressing NeuroD, and the localization of SHP and secretin-producing cells in mouse duodenal epithelium by immunohistochemical stainings. These results indicated that SHP and secretin are potentially co-expressed and lead us to propose a novel regulatory pathway, in which SHP represses NeuroD's positive regulatory activity on secretin gene. © 2006 New York Academy of Sciences. | en_US |
dc.language | eng | en_US |
dc.publisher | Wiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1 | en_US |
dc.relation.ispartof | Annals of the New York Academy of Sciences | en_US |
dc.subject | NeuroD | - |
dc.subject | Secretin | - |
dc.subject | Small heterodimer partner | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Basic Helix-Loop-Helix Transcription Factors - Genetics - Metabolism | en_US |
dc.subject.mesh | Cell Line, Tumor | en_US |
dc.subject.mesh | Duodenum - Metabolism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Immunohistochemistry | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Nerve Tissue Proteins - Genetics - Metabolism | en_US |
dc.subject.mesh | Promoter Regions, Genetic - Genetics | en_US |
dc.subject.mesh | Receptors, Cytoplasmic And Nuclear - Metabolism | en_US |
dc.subject.mesh | Secretin - Genetics - Metabolism | en_US |
dc.title | Localization of small heterodimer partner (SHP) and secretin in mouse duodenal cells | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Lee, LTO: ltolee2@hkucc.hku.hk | en_US |
dc.identifier.email | Chow, BKC: bkcc@hku.hk | en_US |
dc.identifier.authority | Lee, LTO=rp00727 | en_US |
dc.identifier.authority | Chow, BKC=rp00681 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1196/annals.1317.047 | en_US |
dc.identifier.pmid | 16888194 | - |
dc.identifier.scopus | eid_2-s2.0-33746459319 | en_US |
dc.identifier.hkuros | 122734 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33746459319&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 1070 | en_US |
dc.identifier.spage | 371 | en_US |
dc.identifier.epage | 375 | en_US |
dc.identifier.isi | WOS:000240364200051 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lam, IPY=14050702700 | en_US |
dc.identifier.scopusauthorid | Lee, LTO=8367269000 | en_US |
dc.identifier.scopusauthorid | Choi, HS=7404338771 | en_US |
dc.identifier.scopusauthorid | Chow, BKC=7102826193 | en_US |
dc.identifier.issnl | 0077-8923 | - |