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- Publisher Website: 10.1002/hbm.22136
- Scopus: eid_2-s2.0-84886300420
- PMID: 22711376
- WOS: WOS:000326068700008
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Article: Intrinsic resting-state activity predicts working memory brain activation and behavioral performance
Title | Intrinsic resting-state activity predicts working memory brain activation and behavioral performance |
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Authors | |
Keywords | Alff Behavior Load Dependency N-Back Working Memory Resting-State Fmri |
Issue Date | 2013 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751 |
Citation | Human Brain Mapping, 2013, v. 34 n. 12, p. 3204-3215 How to Cite? |
Abstract | Although resting-state brain activity has been demonstrated to correspond with task-evoked brain activation, the relationship between intrinsic and evoked brain activity has not been fully characterized. For example, it is unclear whether intrinsic activity can also predict task-evoked deactivation and whether the rest-task relationship is dependent on task load. In this study, we addressed these issues on 40 healthy control subjects using resting-state and task-driven [N-back working memory (WM) task] functional magnetic resonance imaging data collected in the same session. Using amplitude of low-frequency fluctuation (ALFF) as an index of intrinsic resting-state activity, we found that ALFF in the middle frontal gyrus and inferior/superior parietal lobules was positively correlated with WM task-evoked activation, while ALFF in the medial prefrontal cortex, posterior cingulate cortex, superior frontal gyrus, superior temporal gyrus, and fusiform gyrus was negatively correlated with WM task-evoked deactivation. Further, the relationship between the intrinsic resting-state activity and task-evoked activation in lateral/superior frontal gyri, inferior/superior parietal lobules, superior temporal gyrus, and midline regions was stronger at higher WM task loads. In addition, both resting-state activity and the task-evoked activation in the superior parietal lobule/precuneus were significantly correlated with the WM task behavioral performance, explaining similar portions of intersubject performance variance. Together, these findings suggest that intrinsic resting-state activity facilitates or is permissive of specific brain circuit engagement to perform a cognitive task, and that resting activity can predict subsequent task-evoked brain responses and behavioral performance. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/179557 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.626 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zou, Q | en_US |
dc.contributor.author | Ross, TJ | en_US |
dc.contributor.author | Gu, H | en_US |
dc.contributor.author | Geng, X | en_US |
dc.contributor.author | Zuo, XN | en_US |
dc.contributor.author | Hong, LE | en_US |
dc.contributor.author | Gao, JH | en_US |
dc.contributor.author | Stein, EA | en_US |
dc.contributor.author | Zang, YF | en_US |
dc.contributor.author | Yang, Y | en_US |
dc.date.accessioned | 2012-12-19T09:58:20Z | - |
dc.date.available | 2012-12-19T09:58:20Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Human Brain Mapping, 2013, v. 34 n. 12, p. 3204-3215 | en_US |
dc.identifier.issn | 1065-9471 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179557 | - |
dc.description.abstract | Although resting-state brain activity has been demonstrated to correspond with task-evoked brain activation, the relationship between intrinsic and evoked brain activity has not been fully characterized. For example, it is unclear whether intrinsic activity can also predict task-evoked deactivation and whether the rest-task relationship is dependent on task load. In this study, we addressed these issues on 40 healthy control subjects using resting-state and task-driven [N-back working memory (WM) task] functional magnetic resonance imaging data collected in the same session. Using amplitude of low-frequency fluctuation (ALFF) as an index of intrinsic resting-state activity, we found that ALFF in the middle frontal gyrus and inferior/superior parietal lobules was positively correlated with WM task-evoked activation, while ALFF in the medial prefrontal cortex, posterior cingulate cortex, superior frontal gyrus, superior temporal gyrus, and fusiform gyrus was negatively correlated with WM task-evoked deactivation. Further, the relationship between the intrinsic resting-state activity and task-evoked activation in lateral/superior frontal gyri, inferior/superior parietal lobules, superior temporal gyrus, and midline regions was stronger at higher WM task loads. In addition, both resting-state activity and the task-evoked activation in the superior parietal lobule/precuneus were significantly correlated with the WM task behavioral performance, explaining similar portions of intersubject performance variance. Together, these findings suggest that intrinsic resting-state activity facilitates or is permissive of specific brain circuit engagement to perform a cognitive task, and that resting activity can predict subsequent task-evoked brain responses and behavioral performance. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751 | en_US |
dc.relation.ispartof | Human Brain Mapping | en_US |
dc.subject | Alff | en_US |
dc.subject | Behavior | en_US |
dc.subject | Load Dependency | en_US |
dc.subject | N-Back Working Memory | en_US |
dc.subject | Resting-State Fmri | en_US |
dc.title | Intrinsic resting-state activity predicts working memory brain activation and behavioral performance | en_US |
dc.type | Article | en_US |
dc.identifier.email | Geng, X: gengx@hku.hk | en_US |
dc.identifier.authority | Geng, X=rp01678 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/hbm.22136 | en_US |
dc.identifier.pmid | 22711376 | - |
dc.identifier.scopus | eid_2-s2.0-84886300420 | en_US |
dc.identifier.isi | WOS:000326068700008 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Zou, Q=14025198500 | en_US |
dc.identifier.scopusauthorid | Ross, TJ=7203043487 | en_US |
dc.identifier.scopusauthorid | Gu, H=35233258000 | en_US |
dc.identifier.scopusauthorid | Geng, X=34771310000 | en_US |
dc.identifier.scopusauthorid | Zuo, XN=35091653400 | en_US |
dc.identifier.scopusauthorid | Hong, LE=8654915300 | en_US |
dc.identifier.scopusauthorid | Gao, JH=55252470600 | en_US |
dc.identifier.scopusauthorid | Stein, EA=7202194954 | en_US |
dc.identifier.scopusauthorid | Zang, YF=7102641968 | en_US |
dc.identifier.scopusauthorid | Yang, Y=7409387192 | en_US |
dc.identifier.citeulike | 11038447 | - |
dc.identifier.issnl | 1065-9471 | - |