File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.neuroimage.2008.08.029
- Scopus: eid_2-s2.0-55149116077
- PMID: 18804541
- WOS: WOS:000262300900003
- Find via
Supplementary
-
Bookmarks:
- CiteULike: 1
- Citations:
- Appears in Collections:
Article: Time-dependent correlation of cerebral blood flow with oxygen metabolism in activated human visual cortex as measured by fMRI
Title | Time-dependent correlation of cerebral blood flow with oxygen metabolism in activated human visual cortex as measured by fMRI |
---|---|
Authors | |
Keywords | Cerebral blood flow MRI Oxygen metabolism PET |
Issue Date | 2009 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg |
Citation | Neuroimage, 2009, v. 44 n. 1, p. 16-22 How to Cite? |
Abstract | The aim of this study was to investigate the relationship between relative cerebral blood flow (δCBF) and relative cerebral metabolic rate of oxygen (δCMRO2) during continuous visual stimulation (21 min at 8 Hz) with fMRI biophysical models by simultaneously measuring of BOLD, CBF and CBV fMRI signals. The δCMRO2 was determined by both a newly calibrated single-compartment model (SCM) and a multi-compartment model (MCM) and was in agreement between these two models (P > 0.5). The duration-varying δCBF and δCMRO2 showed a negative correlation with time (r = - 0.97, P < 0.001); i.e., δCBF declines while δCMRO2 increases during continuous stimulation. This study also illustrated that without properly calibrating the critical parameters employed in the SCM, an incorrect and even an opposite appearance of the flow-metabolism relationship during prolonged visual stimulation (positively linear coupling) can result. The time-dependent negative correlation between flow and metabolism demonstrated in this fMRI study is consistent with a previous PET observation and further supports the view that the increase in CBF is driven by factors other than oxygen demand and the energy demands will eventually require increased aerobic metabolism as stimulation continues. © 2008 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/179528 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 2.436 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lin, AL | en_US |
dc.contributor.author | Fox, PT | en_US |
dc.contributor.author | Yang, Y | en_US |
dc.contributor.author | Lu, H | en_US |
dc.contributor.author | Tan, LH | en_US |
dc.contributor.author | Gao, JH | en_US |
dc.date.accessioned | 2012-12-19T09:58:13Z | - |
dc.date.available | 2012-12-19T09:58:13Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Neuroimage, 2009, v. 44 n. 1, p. 16-22 | en_US |
dc.identifier.issn | 1053-8119 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179528 | - |
dc.description.abstract | The aim of this study was to investigate the relationship between relative cerebral blood flow (δCBF) and relative cerebral metabolic rate of oxygen (δCMRO2) during continuous visual stimulation (21 min at 8 Hz) with fMRI biophysical models by simultaneously measuring of BOLD, CBF and CBV fMRI signals. The δCMRO2 was determined by both a newly calibrated single-compartment model (SCM) and a multi-compartment model (MCM) and was in agreement between these two models (P > 0.5). The duration-varying δCBF and δCMRO2 showed a negative correlation with time (r = - 0.97, P < 0.001); i.e., δCBF declines while δCMRO2 increases during continuous stimulation. This study also illustrated that without properly calibrating the critical parameters employed in the SCM, an incorrect and even an opposite appearance of the flow-metabolism relationship during prolonged visual stimulation (positively linear coupling) can result. The time-dependent negative correlation between flow and metabolism demonstrated in this fMRI study is consistent with a previous PET observation and further supports the view that the increase in CBF is driven by factors other than oxygen demand and the energy demands will eventually require increased aerobic metabolism as stimulation continues. © 2008 Elsevier Inc. | en_US |
dc.language | eng | en_US |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg | en_US |
dc.relation.ispartof | NeuroImage | en_US |
dc.subject | Cerebral blood flow | - |
dc.subject | MRI | - |
dc.subject | Oxygen metabolism | - |
dc.subject | PET | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Brain Mapping | en_US |
dc.subject.mesh | Cerebrovascular Circulation - Physiology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Image Interpretation, Computer-Assisted | en_US |
dc.subject.mesh | Magnetic Resonance Imaging | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Oxygen - Metabolism | en_US |
dc.subject.mesh | Photic Stimulation | en_US |
dc.subject.mesh | Time | en_US |
dc.subject.mesh | Visual Cortex - Blood Supply - Metabolism | en_US |
dc.title | Time-dependent correlation of cerebral blood flow with oxygen metabolism in activated human visual cortex as measured by fMRI | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tan, LH: tanlh@hku.hk | en_US |
dc.identifier.authority | Tan, LH=rp01202 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.neuroimage.2008.08.029 | en_US |
dc.identifier.pmid | 18804541 | - |
dc.identifier.scopus | eid_2-s2.0-55149116077 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-55149116077&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 44 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 16 | en_US |
dc.identifier.epage | 22 | en_US |
dc.identifier.isi | WOS:000262300900003 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lin, AL=16835064700 | en_US |
dc.identifier.scopusauthorid | Fox, PT=7402680249 | en_US |
dc.identifier.scopusauthorid | Yang, Y=7409387192 | en_US |
dc.identifier.scopusauthorid | Lu, H=8386439700 | en_US |
dc.identifier.scopusauthorid | Tan, LH=7402233462 | en_US |
dc.identifier.scopusauthorid | Gao, JH=7404475674 | en_US |
dc.identifier.citeulike | 7475776 | - |
dc.identifier.issnl | 1053-8119 | - |