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- Publisher Website: 10.1016/S0091-3057(02)01035-3
- Scopus: eid_2-s2.0-0037306773
- PMID: 12543220
- WOS: WOS:000180769400007
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Article: Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures
Title | Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures |
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Authors | |
Keywords | Amygdala kindling Gabapentin Lamotrigine MK-801 Tolerance |
Issue Date | 2003 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh |
Citation | Pharmacology Biochemistry And Behavior, 2003, v. 74 n. 3, p. 565-571 How to Cite? |
Abstract | The development of tolerance to therapeutic effects of antiepileptic drugs can be a problem in the treatment of epilepsy, bipolar disorder, and pain syndromes. In the present study, acute treatment with the new antiepileptic drug lamotrigine (LTG, 15 mg/kg) markedly suppressed seizure stage and seizure duration in amygdala-kindled rats; but this antiseizure effect was rapidly lost following 4-8 days of repeated treatment. When gabapentin (GBP, 20 mg/kg) was coadministered with LTG, the ability of LTG to suppress seizure stage, seizure duration, and after-discharge (AD) duration was markedly extended. In addition, GBP coadministration with LTG decreased the number of animals that developed LTG-related running fits (Stage 6 seizures) and lengthened the number of days required to develop running fits or complete tolerance. Neither acute nor repeated treatment with MK-801 (0.3 mg/kg), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, had effects on kindled seizures. However, cotreatment with MK-801 markedly extended the anticonvulsant effects of LTG on the three seizure indices and reduced running fits. These data indicate that cotreatment with either GBP or MK-801 slows tolerance development to the anticonvulsant effects of LTG on kindled seizures. Therapeutic implications of the present study remain to be explored. © 2002 Elsevier Science Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/179415 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.050 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, ZJ | en_US |
dc.contributor.author | Russell, S | en_US |
dc.contributor.author | Obeng, K | en_US |
dc.contributor.author | Postma, T | en_US |
dc.contributor.author | Obrocea, G | en_US |
dc.contributor.author | Weiss, SRB | en_US |
dc.contributor.author | Post, RM | en_US |
dc.date.accessioned | 2012-12-19T09:56:17Z | - |
dc.date.available | 2012-12-19T09:56:17Z | - |
dc.date.issued | 2003 | en_US |
dc.identifier.citation | Pharmacology Biochemistry And Behavior, 2003, v. 74 n. 3, p. 565-571 | en_US |
dc.identifier.issn | 0091-3057 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179415 | - |
dc.description.abstract | The development of tolerance to therapeutic effects of antiepileptic drugs can be a problem in the treatment of epilepsy, bipolar disorder, and pain syndromes. In the present study, acute treatment with the new antiepileptic drug lamotrigine (LTG, 15 mg/kg) markedly suppressed seizure stage and seizure duration in amygdala-kindled rats; but this antiseizure effect was rapidly lost following 4-8 days of repeated treatment. When gabapentin (GBP, 20 mg/kg) was coadministered with LTG, the ability of LTG to suppress seizure stage, seizure duration, and after-discharge (AD) duration was markedly extended. In addition, GBP coadministration with LTG decreased the number of animals that developed LTG-related running fits (Stage 6 seizures) and lengthened the number of days required to develop running fits or complete tolerance. Neither acute nor repeated treatment with MK-801 (0.3 mg/kg), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, had effects on kindled seizures. However, cotreatment with MK-801 markedly extended the anticonvulsant effects of LTG on the three seizure indices and reduced running fits. These data indicate that cotreatment with either GBP or MK-801 slows tolerance development to the anticonvulsant effects of LTG on kindled seizures. Therapeutic implications of the present study remain to be explored. © 2002 Elsevier Science Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh | en_US |
dc.relation.ispartof | Pharmacology Biochemistry and Behavior | en_US |
dc.subject | Amygdala kindling | - |
dc.subject | Gabapentin | - |
dc.subject | Lamotrigine | - |
dc.subject | MK-801 | - |
dc.subject | Tolerance | - |
dc.subject.mesh | Acetic Acids - Administration & Dosage | en_US |
dc.subject.mesh | Amines | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anticonvulsants - Administration & Dosage | en_US |
dc.subject.mesh | Cyclohexanecarboxylic Acids | en_US |
dc.subject.mesh | Dizocilpine Maleate - Administration & Dosage | en_US |
dc.subject.mesh | Drug Therapy, Combination | en_US |
dc.subject.mesh | Drug Tolerance - Physiology | en_US |
dc.subject.mesh | Kindling, Neurologic - Drug Effects - Physiology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Seizures - Drug Therapy - Physiopathology | en_US |
dc.subject.mesh | Triazines - Administration & Dosage | en_US |
dc.subject.mesh | Gamma-Aminobutyric Acid | en_US |
dc.title | Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures | en_US |
dc.type | Article | en_US |
dc.identifier.email | Zhang, ZJ: zhangzj@hkucc.hku.hk | en_US |
dc.identifier.authority | Zhang, ZJ=rp01297 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0091-3057(02)01035-3 | en_US |
dc.identifier.pmid | 12543220 | - |
dc.identifier.scopus | eid_2-s2.0-0037306773 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0037306773&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 74 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 565 | en_US |
dc.identifier.epage | 571 | en_US |
dc.identifier.isi | WOS:000180769400007 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Zhang, ZJ=8061473900 | en_US |
dc.identifier.scopusauthorid | Russell, S=7401538133 | en_US |
dc.identifier.scopusauthorid | Obeng, K=6701594477 | en_US |
dc.identifier.scopusauthorid | Postma, T=7003610812 | en_US |
dc.identifier.scopusauthorid | Obrocea, G=6507780112 | en_US |
dc.identifier.scopusauthorid | Weiss, SRB=35448419700 | en_US |
dc.identifier.scopusauthorid | Post, RM=7202218145 | en_US |
dc.identifier.issnl | 0091-3057 | - |