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- Publisher Website: 10.1016/0925-4439(95)00112-3
- Scopus: eid_2-s2.0-0029988539
- PMID: 8608170
- WOS: WOS:A1996TY94500009
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Article: Scavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on the myocardium from the injury of ischemia-reperfusion
Title | Scavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on the myocardium from the injury of ischemia-reperfusion |
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Authors | |
Keywords | Chinonin Electron spin resonance Ischemia-reperfusion injury Nitrous oxide Oxygen free radical |
Issue Date | 1996 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbadis |
Citation | Biochimica Et Biophysica Acta - Molecular Basis Of Disease, 1996, v. 1315 n. 2, p. 131-137 How to Cite? |
Abstract | The scavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on myocardium from the ischemia-reperfusion injury was studied with electron spin resonance (ESR) and chemiluminescence techniques. Chinonin can effectively inhibit the oxidative activity of ONOO-, (the IC50 =7 X 10-5 mmol/L) and scavenge oxygen free radicals generated from the reaction of xanthine and xanthine oxidase (the IC50 = 2.5 X 10-4 mmol/l). It is difficult to find another antioxidant which can scavenge so effectively both ONOO- and oxygen free radicals simultaneously. In the system of ischemia-reperfusion injury of myocardium, Chinonin can, in parallel, scavenge the NO and oxygen free radicals generated from the ischemia-reperfused myocardium, and decrease the activities of lactate dehydrogenase (LDH) and creatine kinase (CK) in the coronary artery effluent of ischemia-reperfused heart and therefore protect the heart from ischemia-reperfusion injury. The protective effect of 0.1 mmol/l Chinonin is similar to that of 1500 U/ml SOD and catalase. |
Persistent Identifier | http://hdl.handle.net/10722/179399 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.580 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhao, BL | en_US |
dc.contributor.author | Shen, JG | en_US |
dc.contributor.author | Li, M | en_US |
dc.contributor.author | Li, MF | en_US |
dc.contributor.author | Wan, Q | en_US |
dc.contributor.author | Xin, WJ | en_US |
dc.date.accessioned | 2012-12-19T09:56:10Z | - |
dc.date.available | 2012-12-19T09:56:10Z | - |
dc.date.issued | 1996 | en_US |
dc.identifier.citation | Biochimica Et Biophysica Acta - Molecular Basis Of Disease, 1996, v. 1315 n. 2, p. 131-137 | en_US |
dc.identifier.issn | 0925-4439 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179399 | - |
dc.description.abstract | The scavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on myocardium from the ischemia-reperfusion injury was studied with electron spin resonance (ESR) and chemiluminescence techniques. Chinonin can effectively inhibit the oxidative activity of ONOO-, (the IC50 =7 X 10-5 mmol/L) and scavenge oxygen free radicals generated from the reaction of xanthine and xanthine oxidase (the IC50 = 2.5 X 10-4 mmol/l). It is difficult to find another antioxidant which can scavenge so effectively both ONOO- and oxygen free radicals simultaneously. In the system of ischemia-reperfusion injury of myocardium, Chinonin can, in parallel, scavenge the NO and oxygen free radicals generated from the ischemia-reperfused myocardium, and decrease the activities of lactate dehydrogenase (LDH) and creatine kinase (CK) in the coronary artery effluent of ischemia-reperfused heart and therefore protect the heart from ischemia-reperfusion injury. The protective effect of 0.1 mmol/l Chinonin is similar to that of 1500 U/ml SOD and catalase. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbadis | en_US |
dc.relation.ispartof | Biochimica et Biophysica Acta - Molecular Basis of Disease | en_US |
dc.subject | Chinonin | - |
dc.subject | Electron spin resonance | - |
dc.subject | Ischemia-reperfusion injury | - |
dc.subject | Nitrous oxide | - |
dc.subject | Oxygen free radical | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arginine - Analogs & Derivatives - Pharmacology | en_US |
dc.subject.mesh | Catalase - Pharmacology | en_US |
dc.subject.mesh | Electron Spin Resonance Spectroscopy | en_US |
dc.subject.mesh | Enzyme Inhibitors - Pharmacology | en_US |
dc.subject.mesh | Free Radical Scavengers - Pharmacology | en_US |
dc.subject.mesh | Free Radicals - Metabolism | en_US |
dc.subject.mesh | Glycosides - Pharmacology | en_US |
dc.subject.mesh | Heart - Drug Effects - Physiology - Physiopathology | en_US |
dc.subject.mesh | Hemoglobins - Metabolism | en_US |
dc.subject.mesh | Kinetics | en_US |
dc.subject.mesh | Luminescent Measurements | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Myocardial Ischemia - Metabolism - Prevention & Control | en_US |
dc.subject.mesh | Myocardial Reperfusion Injury - Metabolism - Prevention & Control | en_US |
dc.subject.mesh | Myocardium - Metabolism | en_US |
dc.subject.mesh | Ng-Nitroarginine Methyl Ester | en_US |
dc.subject.mesh | Nitric Oxide - Metabolism | en_US |
dc.subject.mesh | Nitric Oxide Synthase - Antagonists & Inhibitors | en_US |
dc.subject.mesh | Oxidation-Reduction | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Xanthenes - Pharmacology | en_US |
dc.subject.mesh | Xanthine Oxidase - Metabolism | en_US |
dc.title | Scavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on the myocardium from the injury of ischemia-reperfusion | en_US |
dc.type | Article | en_US |
dc.identifier.email | Shen, JG: shenjg@hku.hk | en_US |
dc.identifier.authority | Shen, JG=rp00487 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0925-4439(95)00112-3 | en_US |
dc.identifier.pmid | 8608170 | - |
dc.identifier.scopus | eid_2-s2.0-0029988539 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0029988539&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 1315 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 131 | en_US |
dc.identifier.epage | 137 | en_US |
dc.identifier.isi | WOS:A1996TY94500009 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Zhao, BL=7403058931 | en_US |
dc.identifier.scopusauthorid | Shen, JG=7404929947 | en_US |
dc.identifier.scopusauthorid | Li, M=36066390600 | en_US |
dc.identifier.scopusauthorid | Li, MF=7405263394 | en_US |
dc.identifier.scopusauthorid | Wan, Q=8891428800 | en_US |
dc.identifier.scopusauthorid | Xin, WJ=7102977683 | en_US |
dc.identifier.issnl | 0925-4439 | - |