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- Publisher Website: 10.1021/jf9014685
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- PMID: 19588925
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Article: Chemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus
Title | Chemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus |
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Authors | |
Keywords | Artocarpus heterophyllus Chemical constituents Phenolic compounds Twigs Tyrosinase inhibitors |
Issue Date | 2009 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau |
Citation | Journal Of Agricultural And Food Chemistry, 2009, v. 57 n. 15, p. 6649-6655 How to Cite? |
Abstract | An HPLC method was developed and validated to compare the chemical profiles and tyrosinase inhibitors in the woods, twigs, roots, and leaves of Artocarpus heterophyllus. Five active tyrosinase inhibitors including dihydromorin, steppogenin, norartocarpetin, artocarpanone, and artocarpesin were used as marker compounds in this HPLC method. It was discovered that the chemical profiles of A. heterophyllus twigs and woods are quite different. Systematic chromatographic methods were further applied to purify the chemicals in the twigs of A. heterophyllus. Four new phenolic compounds, including one isoprenylated 2-arylbenzofuran derivative, artoheterophyllin A (1), and three isoprenylated flavonoids, artoheterophyllin B (2), artoheterophyllin C (3), and artoheterophyllin D (4), together with 16 known compounds, were isolated from the ethanol extract of the twigs of A. heterophyllus. The structures of compounds 1-4 were elucidated by spectroscopic analysis. However, the four new compounds did not show significant inhibitory activities against mushroom tyrosinase compared to kojic acid. It was found that similar compounds, such as norartocarpetin and artocarpesin in the twigs and woods of A. heterophyllus, contributed to their tyrosinase inhibitory activity. © 2009 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/179150 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.114 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zheng, ZP | en_US |
dc.contributor.author | Chen, S | en_US |
dc.contributor.author | Wang, S | en_US |
dc.contributor.author | Wang, XC | en_US |
dc.contributor.author | Cheng, KW | en_US |
dc.contributor.author | Wu, JJ | en_US |
dc.contributor.author | Yang, D | en_US |
dc.contributor.author | Wang, M | en_US |
dc.date.accessioned | 2012-12-19T09:52:23Z | - |
dc.date.available | 2012-12-19T09:52:23Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Journal Of Agricultural And Food Chemistry, 2009, v. 57 n. 15, p. 6649-6655 | en_US |
dc.identifier.issn | 0021-8561 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179150 | - |
dc.description.abstract | An HPLC method was developed and validated to compare the chemical profiles and tyrosinase inhibitors in the woods, twigs, roots, and leaves of Artocarpus heterophyllus. Five active tyrosinase inhibitors including dihydromorin, steppogenin, norartocarpetin, artocarpanone, and artocarpesin were used as marker compounds in this HPLC method. It was discovered that the chemical profiles of A. heterophyllus twigs and woods are quite different. Systematic chromatographic methods were further applied to purify the chemicals in the twigs of A. heterophyllus. Four new phenolic compounds, including one isoprenylated 2-arylbenzofuran derivative, artoheterophyllin A (1), and three isoprenylated flavonoids, artoheterophyllin B (2), artoheterophyllin C (3), and artoheterophyllin D (4), together with 16 known compounds, were isolated from the ethanol extract of the twigs of A. heterophyllus. The structures of compounds 1-4 were elucidated by spectroscopic analysis. However, the four new compounds did not show significant inhibitory activities against mushroom tyrosinase compared to kojic acid. It was found that similar compounds, such as norartocarpetin and artocarpesin in the twigs and woods of A. heterophyllus, contributed to their tyrosinase inhibitory activity. © 2009 American Chemical Society. | en_US |
dc.language | eng | en_US |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau | en_US |
dc.relation.ispartof | Journal of Agricultural and Food Chemistry | en_US |
dc.subject | Artocarpus heterophyllus | - |
dc.subject | Chemical constituents | - |
dc.subject | Phenolic compounds | - |
dc.subject | Twigs | - |
dc.subject | Tyrosinase inhibitors | - |
dc.subject.mesh | Agaricales - Enzymology | en_US |
dc.subject.mesh | Artocarpus - Chemistry | en_US |
dc.subject.mesh | Fungal Proteins - Antagonists & Inhibitors | en_US |
dc.subject.mesh | Monophenol Monooxygenase - Antagonists & Inhibitors | en_US |
dc.subject.mesh | Peptides - Chemistry | en_US |
dc.subject.mesh | Plant Bark - Chemistry | en_US |
dc.subject.mesh | Plant Extracts - Chemistry | en_US |
dc.subject.mesh | Plant Roots - Chemistry | en_US |
dc.title | Chemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wang, M: mfwang@hku.hk | en_US |
dc.identifier.authority | Wang, M=rp00800 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1021/jf9014685 | en_US |
dc.identifier.pmid | 19588925 | - |
dc.identifier.scopus | eid_2-s2.0-68249108904 | en_US |
dc.identifier.hkuros | 163921 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-68249108904&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 57 | en_US |
dc.identifier.issue | 15 | en_US |
dc.identifier.spage | 6649 | en_US |
dc.identifier.epage | 6655 | en_US |
dc.identifier.isi | WOS:000268537300024 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Zheng, ZP=8451746600 | en_US |
dc.identifier.scopusauthorid | Chen, S=41360899900 | en_US |
dc.identifier.scopusauthorid | Wang, S=22136742300 | en_US |
dc.identifier.scopusauthorid | Wang, XC=35206803200 | en_US |
dc.identifier.scopusauthorid | Cheng, KW=12141247000 | en_US |
dc.identifier.scopusauthorid | Wu, JJ=8298828200 | en_US |
dc.identifier.scopusauthorid | Yang, D=41362136400 | en_US |
dc.identifier.scopusauthorid | Wang, M=7406691844 | en_US |
dc.identifier.issnl | 0021-8561 | - |