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- Publisher Website: 10.1016/j.chroma.2004.07.006
- Scopus: eid_2-s2.0-4444256863
- PMID: 15460256
- WOS: WOS:000223560900012
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Article: Preparative isolation and purification of chuanxiongzine from the medicinal plant Ligusticum chuanxiong by high-speed counter-current chromatography
Title | Preparative isolation and purification of chuanxiongzine from the medicinal plant Ligusticum chuanxiong by high-speed counter-current chromatography |
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Authors | |
Keywords | Chuanxiongzine Counter-current chromatography Ligusticum chuanxiong Pharmaceutical analysis Plant materials Preparative chromatography |
Issue Date | 2004 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/chroma |
Citation | Journal Of Chromatography A, 2004, v. 1047 n. 2, p. 249-253 How to Cite? |
Abstract | Ligusticum chuanxiong Hort has been used widely in traditional medicines for the treatment of various kinds of disorders such as cardiovascular and cerebrovascular diseases. High-speed counter-current chromatography was applied to the isolation and purification of the bioactive component chuanxiongzine from L. chuanxiong Hort. The crude chuanxiongzine was obtained by extraction with ethanol from the dried roots of L. chuanxiong Hort under sonication. Preparative high-speed counter-current chromatography with a two-phase solvent system composed of n-hexane-ethyl acetate-ethanol-water (5:5:3:7, v/v) was successfully performed yielding 11.5 mg chuanxiongzine at 96.8% purity from 300 mg of the crude extract (4.2% chuanxiongzine) with the recovery of 91% in a one-step separation. © 2004 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/179055 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 0.717 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Li, HB | en_US |
dc.contributor.author | Chen, F | en_US |
dc.date.accessioned | 2012-12-19T09:51:41Z | - |
dc.date.available | 2012-12-19T09:51:41Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Journal Of Chromatography A, 2004, v. 1047 n. 2, p. 249-253 | en_US |
dc.identifier.issn | 0021-9673 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179055 | - |
dc.description.abstract | Ligusticum chuanxiong Hort has been used widely in traditional medicines for the treatment of various kinds of disorders such as cardiovascular and cerebrovascular diseases. High-speed counter-current chromatography was applied to the isolation and purification of the bioactive component chuanxiongzine from L. chuanxiong Hort. The crude chuanxiongzine was obtained by extraction with ethanol from the dried roots of L. chuanxiong Hort under sonication. Preparative high-speed counter-current chromatography with a two-phase solvent system composed of n-hexane-ethyl acetate-ethanol-water (5:5:3:7, v/v) was successfully performed yielding 11.5 mg chuanxiongzine at 96.8% purity from 300 mg of the crude extract (4.2% chuanxiongzine) with the recovery of 91% in a one-step separation. © 2004 Elsevier B.V. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/chroma | en_US |
dc.relation.ispartof | Journal of Chromatography A | en_US |
dc.rights | Journal of Chromatography A. Copyright © Elsevier BV. | - |
dc.subject | Chuanxiongzine | - |
dc.subject | Counter-current chromatography | - |
dc.subject | Ligusticum chuanxiong | - |
dc.subject | Pharmaceutical analysis | - |
dc.subject | Plant materials | - |
dc.subject | Preparative chromatography | - |
dc.subject.mesh | Countercurrent Distribution - Methods | en_US |
dc.subject.mesh | Drugs, Chinese Herbal - Chemistry | en_US |
dc.subject.mesh | Plant Extracts - Isolation & Purification | en_US |
dc.subject.mesh | Plants, Medicinal - Chemistry | en_US |
dc.subject.mesh | Pyrazines - Isolation & Purification | en_US |
dc.title | Preparative isolation and purification of chuanxiongzine from the medicinal plant Ligusticum chuanxiong by high-speed counter-current chromatography | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chen, F: sfchen@hku.hk | en_US |
dc.identifier.authority | Chen, F=rp00672 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.chroma.2004.07.006 | en_US |
dc.identifier.pmid | 15460256 | - |
dc.identifier.scopus | eid_2-s2.0-4444256863 | en_US |
dc.identifier.hkuros | 105985 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-4444256863&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 1047 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 249 | en_US |
dc.identifier.epage | 253 | en_US |
dc.identifier.isi | WOS:000223560900012 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Li, HB=25649944400 | en_US |
dc.identifier.scopusauthorid | Chen, F=7404907980 | en_US |
dc.identifier.issnl | 0021-9673 | - |