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- Publisher Website: 10.1016/j.cbpa.2005.11.021
- Scopus: eid_2-s2.0-33745456254
- PMID: 16406825
- WOS: WOS:000238730400005
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Article: Feedback regulation of growth hormone synthesis and secretion in fish and the emerging concept of intrapituitary feedback loop
Title | Feedback regulation of growth hormone synthesis and secretion in fish and the emerging concept of intrapituitary feedback loop |
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Authors | |
Keywords | Autocrine/paracrine interactions Feedback control Fish Gene expression Gonadotrophs Growth hormone Luteinizing hormone Pituitary Signal transduction Somatotrophs |
Issue Date | 2006 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cbpa |
Citation | Comparative Biochemistry And Physiology - A Molecular And Integrative Physiology, 2006, v. 144 n. 3, p. 284-305 How to Cite? |
Abstract | Growth hormone (GH) is known to play a key role in the regulation of body growth and metabolism. Similar to mammals, GH secretion in fish is under the control of hypothalamic factors. Besides, signals generated within the pituitary and/or from peripheral tissues/organs can also exert a feedback control on GH release by effects acting on both the hypothalamus and/or anterior pituitary. Among these feedback signals, the functional role of IGF is well conserved from fish to mammals. In contrast, the effects of steroids and thyroid hormones are more variable and appear to be species-specific. Recently, a novel intrapituitary feedback loop regulating GH release and GH gene expression has been identified in fish. This feedback loop has three functional components: (i) LH induction of GH release from somatotrophs, (ii) amplification of GH secretion by GH autoregulation in somatotrophs, and (iii) GH feedback inhibition of LH release from neighboring gonadotrophs. In this article, the mechanisms for feedback control of GH synthesis and secretion are reviewed and functional implications of this local feedback loop are discussed. This intrapituitary feedback loop may represent a new facet of pituitary research with potential applications in aquaculture and clinical studies. © 2005 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/178944 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.630 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wong, AOL | en_US |
dc.contributor.author | Zhou, H | en_US |
dc.contributor.author | Jiang, Y | en_US |
dc.contributor.author | Ko, WKW | en_US |
dc.date.accessioned | 2012-12-19T09:50:55Z | - |
dc.date.available | 2012-12-19T09:50:55Z | - |
dc.date.issued | 2006 | en_US |
dc.identifier.citation | Comparative Biochemistry And Physiology - A Molecular And Integrative Physiology, 2006, v. 144 n. 3, p. 284-305 | en_US |
dc.identifier.issn | 1095-6433 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178944 | - |
dc.description.abstract | Growth hormone (GH) is known to play a key role in the regulation of body growth and metabolism. Similar to mammals, GH secretion in fish is under the control of hypothalamic factors. Besides, signals generated within the pituitary and/or from peripheral tissues/organs can also exert a feedback control on GH release by effects acting on both the hypothalamus and/or anterior pituitary. Among these feedback signals, the functional role of IGF is well conserved from fish to mammals. In contrast, the effects of steroids and thyroid hormones are more variable and appear to be species-specific. Recently, a novel intrapituitary feedback loop regulating GH release and GH gene expression has been identified in fish. This feedback loop has three functional components: (i) LH induction of GH release from somatotrophs, (ii) amplification of GH secretion by GH autoregulation in somatotrophs, and (iii) GH feedback inhibition of LH release from neighboring gonadotrophs. In this article, the mechanisms for feedback control of GH synthesis and secretion are reviewed and functional implications of this local feedback loop are discussed. This intrapituitary feedback loop may represent a new facet of pituitary research with potential applications in aquaculture and clinical studies. © 2005 Elsevier Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cbpa | en_US |
dc.relation.ispartof | Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology | en_US |
dc.subject | Autocrine/paracrine interactions | - |
dc.subject | Feedback control | - |
dc.subject | Fish | - |
dc.subject | Gene expression | - |
dc.subject | Gonadotrophs | - |
dc.subject | Growth hormone | - |
dc.subject | Luteinizing hormone | - |
dc.subject | Pituitary | - |
dc.subject | Signal transduction | - |
dc.subject | Somatotrophs | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Feedback, Physiological | en_US |
dc.subject.mesh | Fishes - Metabolism | en_US |
dc.subject.mesh | Gene Expression Regulation | en_US |
dc.subject.mesh | Gonadotropins - Metabolism | en_US |
dc.subject.mesh | Growth Hormone - Biosynthesis - Metabolism | en_US |
dc.subject.mesh | Luteinizing Hormone - Metabolism | en_US |
dc.subject.mesh | Mammals - Metabolism | en_US |
dc.subject.mesh | Pituitary Gland - Metabolism | en_US |
dc.title | Feedback regulation of growth hormone synthesis and secretion in fish and the emerging concept of intrapituitary feedback loop | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wong, AOL: olwong@hkucc.hku.hk | en_US |
dc.identifier.authority | Wong, AOL=rp00806 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.cbpa.2005.11.021 | en_US |
dc.identifier.pmid | 16406825 | - |
dc.identifier.scopus | eid_2-s2.0-33745456254 | en_US |
dc.identifier.hkuros | 123601 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33745456254&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 144 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 284 | en_US |
dc.identifier.epage | 305 | en_US |
dc.identifier.isi | WOS:000238730400005 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Wong, AOL=7403147570 | en_US |
dc.identifier.scopusauthorid | Zhou, H=7404742310 | en_US |
dc.identifier.scopusauthorid | Jiang, Y=15061459000 | en_US |
dc.identifier.scopusauthorid | Ko, WKW=7202286890 | en_US |
dc.identifier.issnl | 1095-6433 | - |