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- Publisher Website: 10.1007/s10709-005-3146-0
- Scopus: eid_2-s2.0-21744462237
- PMID: 16134337
- WOS: WOS:000230266000013
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Article: Functional divergence of the circadian clock proteins in prokaryotes
Title | Functional divergence of the circadian clock proteins in prokaryotes |
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Authors | |
Keywords | Circadian genes Cyanobacteria Functional divergence Rate shift |
Issue Date | 2005 |
Publisher | Springer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0016-6707 |
Citation | Genetica, 2005, v. 124 n. 2, p. 247-254 How to Cite? |
Abstract | Cyanobacteria are only prokaryotes known so far to have a circadian system. It may be based either on two (kaiB and kaiC) or three (kaiA, kaiB and kaiC) circadian genes. The homologs of two circadian proteins, KaiB and KaiC, form four major subfamilies (K1-K4) and also occur in some other prokaryotes. Using the likelihood-ratio tests, we studied a rate shift at the functional divergence of the proteins from the different subfamilies. It appears that only two of the subfamilies (K1 and K2) perform circadian functions. We identified in total 92 sites that have significantly different rates of evolution between the clades K1/K2 and K3/K4; 67 sites (15 in KaiB and 52 in KaiC) been evolving significantly slower in K1/K2 than the overall average for the entire sequence. Many critical sites are located in the identified functionally important motifs and regions, e.g. one of the Walker's motif As, DXXG motif, and two KaiA-binding domains of KaiC. There are also 36 sites (∼5%) with rate shift between K1 and K2. The rate shift at these sites may be related to the interaction with KaiA. Rate shift analyses have identified residues whose manipulation in the Kai proteins may lead to better understanding of their functions in the two different types of the cyanobacterial circadian system. © Springer 2005. |
Persistent Identifier | http://hdl.handle.net/10722/178892 |
ISSN | 2023 Impact Factor: 1.3 2023 SCImago Journal Rankings: 0.390 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dvornyk, V | en_US |
dc.contributor.author | Knudsen, B | en_US |
dc.date.accessioned | 2012-12-19T09:50:30Z | - |
dc.date.available | 2012-12-19T09:50:30Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Genetica, 2005, v. 124 n. 2, p. 247-254 | en_US |
dc.identifier.issn | 0016-6707 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178892 | - |
dc.description.abstract | Cyanobacteria are only prokaryotes known so far to have a circadian system. It may be based either on two (kaiB and kaiC) or three (kaiA, kaiB and kaiC) circadian genes. The homologs of two circadian proteins, KaiB and KaiC, form four major subfamilies (K1-K4) and also occur in some other prokaryotes. Using the likelihood-ratio tests, we studied a rate shift at the functional divergence of the proteins from the different subfamilies. It appears that only two of the subfamilies (K1 and K2) perform circadian functions. We identified in total 92 sites that have significantly different rates of evolution between the clades K1/K2 and K3/K4; 67 sites (15 in KaiB and 52 in KaiC) been evolving significantly slower in K1/K2 than the overall average for the entire sequence. Many critical sites are located in the identified functionally important motifs and regions, e.g. one of the Walker's motif As, DXXG motif, and two KaiA-binding domains of KaiC. There are also 36 sites (∼5%) with rate shift between K1 and K2. The rate shift at these sites may be related to the interaction with KaiA. Rate shift analyses have identified residues whose manipulation in the Kai proteins may lead to better understanding of their functions in the two different types of the cyanobacterial circadian system. © Springer 2005. | en_US |
dc.language | eng | en_US |
dc.publisher | Springer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0016-6707 | en_US |
dc.relation.ispartof | Genetica | en_US |
dc.subject | Circadian genes | - |
dc.subject | Cyanobacteria | - |
dc.subject | Functional divergence | - |
dc.subject | Rate shift | - |
dc.subject.mesh | Amino Acid Motifs | en_US |
dc.subject.mesh | Amino Acid Sequence | en_US |
dc.subject.mesh | Bacterial Proteins - Chemistry - Genetics - Physiology | en_US |
dc.subject.mesh | Circadian Rhythm - Genetics - Physiology | en_US |
dc.subject.mesh | Circadian Rhythm Signaling Peptides And Proteins | en_US |
dc.subject.mesh | Cyanobacteria - Genetics - Physiology | en_US |
dc.subject.mesh | Evolution, Molecular | en_US |
dc.subject.mesh | Genes, Bacterial | en_US |
dc.subject.mesh | Molecular Sequence Data | en_US |
dc.subject.mesh | Phylogeny | en_US |
dc.subject.mesh | Prokaryotic Cells | en_US |
dc.subject.mesh | Protein Structure, Tertiary | en_US |
dc.subject.mesh | Sequence Homology, Amino Acid | en_US |
dc.title | Functional divergence of the circadian clock proteins in prokaryotes | en_US |
dc.type | Article | en_US |
dc.identifier.email | Dvornyk, V: dvornyk@hku.hk | en_US |
dc.identifier.authority | Dvornyk, V=rp00693 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s10709-005-3146-0 | en_US |
dc.identifier.pmid | 16134337 | - |
dc.identifier.scopus | eid_2-s2.0-21744462237 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-21744462237&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 124 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 247 | en_US |
dc.identifier.epage | 254 | en_US |
dc.identifier.isi | WOS:000230266000013 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Dvornyk, V=6701789786 | en_US |
dc.identifier.scopusauthorid | Knudsen, B=7004937723 | en_US |
dc.identifier.citeulike | 246378 | - |
dc.identifier.issnl | 0016-6707 | - |