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- Scopus: eid_2-s2.0-0023107133
- PMID: 3809176
- WOS: WOS:A1987F949700018
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Article: Diminished hepatic growth hormone receptor binding in sex-linked dwarf broiler and leghorn chickens (42473)
Title | Diminished hepatic growth hormone receptor binding in sex-linked dwarf broiler and leghorn chickens (42473) |
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Authors | |
Issue Date | 1987 |
Publisher | Society for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/ |
Citation | Proceedings Of The Society For Experimental Biology And Medicine, 1987, v. 184 n. 2, p. 234-238 How to Cite? |
Abstract | Hepatic growth hormone (GH) receptor binding was compared in normal and sex-linked dwarfs (SLD) from both Hubbard and Cornell strain chickens. At 6, 8, and 20 weeks of age, hepatic GH receptor binding in the Hubbard SLD chickens was significantly lower than that of normal fast-growing birds. At 20 weeks of age, only 2 of 22 SLD chickens in the Hubbard broiler strain showed positive binding at a high enough level to allow for Scatchard analysis. The affinity constants and binding capacities of these two SLD chickens were numerically (but not significantly) lower than those of the normal fast-growing birds. We further examined hepatic GH receptor binding in two closely related White Leghorn strains of chickens that have been maintained as closed breeding populations for many years. We observed no detectable hepatic GH binding in the Cornell SLD chickens (N=20), as compared to the normal-growing control strain (K strain). In both SLD strains, pretreatment with 4 M MgCl2 did not enhance GH binding, suggesting that there was no endogenous GH binding to the receptor. Based on these data, we suggest that the lack, or greatly reduced number, of GH receptors may be a major contributing factor to the dwarfism observed in these strains. |
Persistent Identifier | http://hdl.handle.net/10722/178456 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Leung, FC | en_US |
dc.contributor.author | Styles, WJ | en_US |
dc.contributor.author | Rosenblum, CI | en_US |
dc.date.accessioned | 2012-12-19T09:47:47Z | - |
dc.date.available | 2012-12-19T09:47:47Z | - |
dc.date.issued | 1987 | en_US |
dc.identifier.citation | Proceedings Of The Society For Experimental Biology And Medicine, 1987, v. 184 n. 2, p. 234-238 | en_US |
dc.identifier.issn | 0037-9727 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178456 | - |
dc.description.abstract | Hepatic growth hormone (GH) receptor binding was compared in normal and sex-linked dwarfs (SLD) from both Hubbard and Cornell strain chickens. At 6, 8, and 20 weeks of age, hepatic GH receptor binding in the Hubbard SLD chickens was significantly lower than that of normal fast-growing birds. At 20 weeks of age, only 2 of 22 SLD chickens in the Hubbard broiler strain showed positive binding at a high enough level to allow for Scatchard analysis. The affinity constants and binding capacities of these two SLD chickens were numerically (but not significantly) lower than those of the normal fast-growing birds. We further examined hepatic GH receptor binding in two closely related White Leghorn strains of chickens that have been maintained as closed breeding populations for many years. We observed no detectable hepatic GH binding in the Cornell SLD chickens (N=20), as compared to the normal-growing control strain (K strain). In both SLD strains, pretreatment with 4 M MgCl2 did not enhance GH binding, suggesting that there was no endogenous GH binding to the receptor. Based on these data, we suggest that the lack, or greatly reduced number, of GH receptors may be a major contributing factor to the dwarfism observed in these strains. | en_US |
dc.language | eng | en_US |
dc.publisher | Society for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/ | en_US |
dc.relation.ispartof | Proceedings of the Society for Experimental Biology and Medicine | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Chickens | en_US |
dc.subject.mesh | Dwarfism - Genetics - Metabolism - Veterinary | en_US |
dc.subject.mesh | Liver - Metabolism | en_US |
dc.subject.mesh | Magnesium - Pharmacology | en_US |
dc.subject.mesh | Magnesium Chloride | en_US |
dc.subject.mesh | Poultry Diseases - Genetics - Metabolism | en_US |
dc.subject.mesh | Receptors, Somatotropin - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Sex Factors | en_US |
dc.subject.mesh | Species Specificity | en_US |
dc.title | Diminished hepatic growth hormone receptor binding in sex-linked dwarf broiler and leghorn chickens (42473) | en_US |
dc.type | Article | en_US |
dc.identifier.email | Leung, FC: fcleung@hkucc.hku.hk | en_US |
dc.identifier.authority | Leung, FC=rp00731 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 3809176 | - |
dc.identifier.scopus | eid_2-s2.0-0023107133 | en_US |
dc.identifier.volume | 184 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 234 | en_US |
dc.identifier.epage | 238 | en_US |
dc.identifier.isi | WOS:A1987F949700018 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Leung, FC=7103078633 | en_US |
dc.identifier.scopusauthorid | Styles, WJ=6603625839 | en_US |
dc.identifier.scopusauthorid | Rosenblum, CI=6701587112 | en_US |
dc.identifier.issnl | 0037-9727 | - |