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- Publisher Website: 10.1038/sj.eye.6701585
- Scopus: eid_2-s2.0-21244461882
- PMID: 15184946
- WOS: WOS:000229561700005
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Article: Ocular-hypertensive response and corneal endothelial changes after intravitreal triamcinolone injections in Chinese subjects: A 6-month follow-up study
Title | Ocular-hypertensive response and corneal endothelial changes after intravitreal triamcinolone injections in Chinese subjects: A 6-month follow-up study |
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Authors | |
Keywords | Intraocular pressure Intravitreal triamcinolone Specular microscopy |
Issue Date | 2005 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/eye |
Citation | Eye, 2005, v. 19 n. 6, p. 625-630 How to Cite? |
Abstract | Purpose: To assess the intraocular pressure (IOP) and corneal endothelial changes, over a 6-month period, after a single injection of intravitreal triamcinolone (ivTA) in Chinese patients. Methods: A total of 43 eyes of 43 consecutive Chinese patients with various macular diseases received a single bolus injection of 4 mg ivTA, of which, 14 eyes with significant cataracts underwent simultaneous phacoemulsification and primary intraocular lens implantation. IOP was measured preoperatively and weekly in the first month, and then monthly until 6 months postinjection. Specular microscopy was performed on 24 of the 29 eyes without simultaneous cataract surgery, preoperatively and at months 1, 3, and 6. Results: All patients completed 6 months of follow-up. Nine out of 43 (20.9%) eyes had IOP >21 mmHg. Their mean maximum IOP was 29.2 mmHg (range 23.0-37.0), necessitating the use of 2.0 types of topical antiglaucomatous medications on average. The IOP elevation occurred at a mean of 5.2 weeks (range 1-17) postinjection. All IOPs returned to normal, without additional antiglaucomatous medications, by 6 months. There was no statistically significant difference (paired t-test, P < 0.05) in the corneal endothelial cell count and other specular microscopy parameters up to 6 months after the injections. Conclusion: A single 4 mg bolus injection of ivTA appeared to have no harmful effects on the corneal endothelium. IvTA caused transient IOP elevations in 20.9% of Chinese patients, similar to that observed in Caucasians. As the IOP rise can occur as early as 1 week after the injection, early monitoring will help its early detection and prevent optic nerve damage. © 2005 Nature Publishing Group All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/176419 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 1.373 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, CKM | en_US |
dc.contributor.author | Fan, DSP | en_US |
dc.contributor.author | Chan, WM | en_US |
dc.contributor.author | Lai, WW | en_US |
dc.contributor.author | Lee, VYW | en_US |
dc.contributor.author | Lam, DSC | en_US |
dc.date.accessioned | 2012-11-26T09:11:09Z | - |
dc.date.available | 2012-11-26T09:11:09Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Eye, 2005, v. 19 n. 6, p. 625-630 | en_US |
dc.identifier.issn | 0950-222X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/176419 | - |
dc.description.abstract | Purpose: To assess the intraocular pressure (IOP) and corneal endothelial changes, over a 6-month period, after a single injection of intravitreal triamcinolone (ivTA) in Chinese patients. Methods: A total of 43 eyes of 43 consecutive Chinese patients with various macular diseases received a single bolus injection of 4 mg ivTA, of which, 14 eyes with significant cataracts underwent simultaneous phacoemulsification and primary intraocular lens implantation. IOP was measured preoperatively and weekly in the first month, and then monthly until 6 months postinjection. Specular microscopy was performed on 24 of the 29 eyes without simultaneous cataract surgery, preoperatively and at months 1, 3, and 6. Results: All patients completed 6 months of follow-up. Nine out of 43 (20.9%) eyes had IOP >21 mmHg. Their mean maximum IOP was 29.2 mmHg (range 23.0-37.0), necessitating the use of 2.0 types of topical antiglaucomatous medications on average. The IOP elevation occurred at a mean of 5.2 weeks (range 1-17) postinjection. All IOPs returned to normal, without additional antiglaucomatous medications, by 6 months. There was no statistically significant difference (paired t-test, P < 0.05) in the corneal endothelial cell count and other specular microscopy parameters up to 6 months after the injections. Conclusion: A single 4 mg bolus injection of ivTA appeared to have no harmful effects on the corneal endothelium. IvTA caused transient IOP elevations in 20.9% of Chinese patients, similar to that observed in Caucasians. As the IOP rise can occur as early as 1 week after the injection, early monitoring will help its early detection and prevent optic nerve damage. © 2005 Nature Publishing Group All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/eye | en_US |
dc.relation.ispartof | Eye | en_US |
dc.subject | Intraocular pressure | - |
dc.subject | Intravitreal triamcinolone | - |
dc.subject | Specular microscopy | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 And Over | en_US |
dc.subject.mesh | Anti-Inflammatory Agents - Administration & Dosage | en_US |
dc.subject.mesh | Cataract Extraction | en_US |
dc.subject.mesh | China | en_US |
dc.subject.mesh | Endothelium, Corneal - Drug Effects | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Follow-Up Studies | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Injections | en_US |
dc.subject.mesh | Intraocular Pressure - Drug Effects | en_US |
dc.subject.mesh | Intraoperative Period | en_US |
dc.subject.mesh | Macular Degeneration - Complications | en_US |
dc.subject.mesh | Macular Edema - Complications | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Triamcinolone - Administration & Dosage | en_US |
dc.subject.mesh | Vitreous Body | en_US |
dc.title | Ocular-hypertensive response and corneal endothelial changes after intravitreal triamcinolone injections in Chinese subjects: A 6-month follow-up study | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lai, WW: wicolai@hku.hk | en_US |
dc.identifier.authority | Lai, WW=rp00531 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1038/sj.eye.6701585 | en_US |
dc.identifier.pmid | 15184946 | - |
dc.identifier.scopus | eid_2-s2.0-21244461882 | en_US |
dc.identifier.hkuros | 164018 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-21244461882&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 19 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 625 | en_US |
dc.identifier.epage | 630 | en_US |
dc.identifier.isi | WOS:000229561700005 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Chan, CKM=7404813824 | en_US |
dc.identifier.scopusauthorid | Fan, DSP=7202965663 | en_US |
dc.identifier.scopusauthorid | Chan, WM=7403914485 | en_US |
dc.identifier.scopusauthorid | Lai, WW=7402231098 | en_US |
dc.identifier.scopusauthorid | Lee, VYW=8078995500 | en_US |
dc.identifier.scopusauthorid | Lam, DSC=35500200200 | en_US |
dc.identifier.issnl | 0950-222X | - |