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Article: Effect of melanin on traumatic hyphema in rabbits
Title | Effect of melanin on traumatic hyphema in rabbits |
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Authors | |
Issue Date | 1999 |
Publisher | American Medical Association. The Journal's web site is located at http://www.archopthalmol.com |
Citation | Archives Of Ophthalmology, 1999, v. 117 n. 6, p. 789-793 How to Cite? |
Abstract | Objective: To investigate the role of melanin in influencing the clearance of traumatic hyphema and in the incidence of rebleeds following the hyphemas. Methods: Hyphemas were induced in 30 eyes of New Zealand white albino rabbits using an Nd:YAG laser. A total of 3.75 mg of synthetic melanin suspended in 0.1 mL of balanced salt solution was introduced into the anterior chambers of 16 animals. A total of 0.1 mL of balanced salt solution was injected into 14 control eyes. Hyphema levels were measured by a masked observer (V.D.B.) daily for 15 days. Pairs of animals were sacrificed at 1, 3, 5, 10, and 15 days and the eyes studied histologically. Results: Hyphemas were consistently produced in all eyes with mean ± SD levels of 1.44 ± 0.22 mm and 1.57 ± 0.24 mm in the melanin-treated and control eyes, respectively. The clearance of hyphemas in the melanin-treated eyes was significantly prolonged throughout the study (P < .001). The rate of rebleed in the melanin-treated group was 18.8% and in the control group was 7.1% (P < .01). Histologically, both groups showed variable degrees of blood in the anterior chambers and trabecular meshwork. In addition, the melanin-treated eyes showed free melanin, melanin-laden macrophages, and an inflammatory response in the anterior chamber and trabecular meshwork that was greater than that in the control eyes. Melanin-treated eyes with rebleeds showed organized hemorrhage with neovascularization. Conclusions: The presence of melanin results in a significantly prolonged course of hyphemas and may influence the rate of rebleeds. Occlusion of the trabecular meshwork with melanin-laden macrophages and inflammation may be the mechanisms responsible for these effects. Clinical Relevance: The release of melanin into the anterior chamber during ocular trauma may be partly responsible for the susceptibility of darker-pigmented individuals to more serious complications following a traumatic hyphema. |
Persistent Identifier | http://hdl.handle.net/10722/176356 |
ISSN | 2014 Impact Factor: 4.399 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lai, WW | en_US |
dc.contributor.author | Bhavnani, VD | en_US |
dc.contributor.author | Tessler, HH | en_US |
dc.contributor.author | Edward, DP | en_US |
dc.date.accessioned | 2012-11-26T09:10:47Z | - |
dc.date.available | 2012-11-26T09:10:47Z | - |
dc.date.issued | 1999 | en_US |
dc.identifier.citation | Archives Of Ophthalmology, 1999, v. 117 n. 6, p. 789-793 | en_US |
dc.identifier.issn | 0003-9950 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/176356 | - |
dc.description.abstract | Objective: To investigate the role of melanin in influencing the clearance of traumatic hyphema and in the incidence of rebleeds following the hyphemas. Methods: Hyphemas were induced in 30 eyes of New Zealand white albino rabbits using an Nd:YAG laser. A total of 3.75 mg of synthetic melanin suspended in 0.1 mL of balanced salt solution was introduced into the anterior chambers of 16 animals. A total of 0.1 mL of balanced salt solution was injected into 14 control eyes. Hyphema levels were measured by a masked observer (V.D.B.) daily for 15 days. Pairs of animals were sacrificed at 1, 3, 5, 10, and 15 days and the eyes studied histologically. Results: Hyphemas were consistently produced in all eyes with mean ± SD levels of 1.44 ± 0.22 mm and 1.57 ± 0.24 mm in the melanin-treated and control eyes, respectively. The clearance of hyphemas in the melanin-treated eyes was significantly prolonged throughout the study (P < .001). The rate of rebleed in the melanin-treated group was 18.8% and in the control group was 7.1% (P < .01). Histologically, both groups showed variable degrees of blood in the anterior chambers and trabecular meshwork. In addition, the melanin-treated eyes showed free melanin, melanin-laden macrophages, and an inflammatory response in the anterior chamber and trabecular meshwork that was greater than that in the control eyes. Melanin-treated eyes with rebleeds showed organized hemorrhage with neovascularization. Conclusions: The presence of melanin results in a significantly prolonged course of hyphemas and may influence the rate of rebleeds. Occlusion of the trabecular meshwork with melanin-laden macrophages and inflammation may be the mechanisms responsible for these effects. Clinical Relevance: The release of melanin into the anterior chamber during ocular trauma may be partly responsible for the susceptibility of darker-pigmented individuals to more serious complications following a traumatic hyphema. | en_US |
dc.language | eng | en_US |
dc.publisher | American Medical Association. The Journal's web site is located at http://www.archopthalmol.com | en_US |
dc.relation.ispartof | Archives of Ophthalmology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anterior Chamber - Drug Effects - Pathology | en_US |
dc.subject.mesh | Eye Injuries - Complications - Pathology - Physiopathology | en_US |
dc.subject.mesh | Hyphema - Etiology - Pathology - Physiopathology | en_US |
dc.subject.mesh | Iris - Blood Supply - Injuries - Pathology | en_US |
dc.subject.mesh | Macrophages - Pathology | en_US |
dc.subject.mesh | Melanins - Pharmacology | en_US |
dc.subject.mesh | Rabbits | en_US |
dc.subject.mesh | Recurrence | en_US |
dc.title | Effect of melanin on traumatic hyphema in rabbits | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lai, WW: wicolai@hku.hk | en_US |
dc.identifier.authority | Lai, WW=rp00531 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1001/archopht.117.6.789 | - |
dc.identifier.pmid | 10369591 | - |
dc.identifier.scopus | eid_2-s2.0-0032989296 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032989296&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 117 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 789 | en_US |
dc.identifier.epage | 793 | en_US |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lai, WW=7402231098 | en_US |
dc.identifier.scopusauthorid | Bhavnani, VD=14719230500 | en_US |
dc.identifier.scopusauthorid | Tessler, HH=7003279432 | en_US |
dc.identifier.scopusauthorid | Edward, DP=7005234763 | en_US |
dc.identifier.issnl | 0003-9950 | - |