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Article: Evidence of a non-vagal mechanism of pancreatic polypeptide release in man
Title | Evidence of a non-vagal mechanism of pancreatic polypeptide release in man |
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Authors | |
Issue Date | 1981 |
Citation | Italian Journal Of Gastroenterology, 1981, v. 13 n. 4, p. 244-247 How to Cite? |
Abstract | The Pancreatic polypeptide (PP) response to a protein meal was measured in 10 healthy volunteers, 10 duodenal ulcer patients, and 6 gastrectomized patients. No significant differences were found between normal and duodenal ulcer subjects, whereas, in gastrectomized patients, basal and food-stimulated plasma PP concentrations were significantly lower (p<0.05). The latter patients, although lacking vagal innervation, showed significantly increased PP levels (p<0.05) 30 min after the beginning of the meal. However, the same secretory pattern related to baseline levels was recorded in all groups: an inverse correlation between basal PP output and stimulated PP output/basal PP output was noted. These results indicate that a humoral mechanism is probably involved in the release of PP, and, furthermore, that neural and paracrine factors may contribute to the regulation of basal and food-stimulated PP concentrations. |
Persistent Identifier | http://hdl.handle.net/10722/176236 |
ISSN |
DC Field | Value | Language |
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dc.contributor.author | Annibale, B | en_US |
dc.contributor.author | Bruzzone, R | en_US |
dc.contributor.author | Severi, C | en_US |
dc.date.accessioned | 2012-11-26T09:07:28Z | - |
dc.date.available | 2012-11-26T09:07:28Z | - |
dc.date.issued | 1981 | en_US |
dc.identifier.citation | Italian Journal Of Gastroenterology, 1981, v. 13 n. 4, p. 244-247 | en_US |
dc.identifier.issn | 0392-0623 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/176236 | - |
dc.description.abstract | The Pancreatic polypeptide (PP) response to a protein meal was measured in 10 healthy volunteers, 10 duodenal ulcer patients, and 6 gastrectomized patients. No significant differences were found between normal and duodenal ulcer subjects, whereas, in gastrectomized patients, basal and food-stimulated plasma PP concentrations were significantly lower (p<0.05). The latter patients, although lacking vagal innervation, showed significantly increased PP levels (p<0.05) 30 min after the beginning of the meal. However, the same secretory pattern related to baseline levels was recorded in all groups: an inverse correlation between basal PP output and stimulated PP output/basal PP output was noted. These results indicate that a humoral mechanism is probably involved in the release of PP, and, furthermore, that neural and paracrine factors may contribute to the regulation of basal and food-stimulated PP concentrations. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Italian Journal of Gastroenterology | en_US |
dc.title | Evidence of a non-vagal mechanism of pancreatic polypeptide release in man | en_US |
dc.type | Article | en_US |
dc.identifier.email | Bruzzone, R: bruzzone@hkucc.hku.hk | en_US |
dc.identifier.authority | Bruzzone, R=rp01442 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.scopus | eid_2-s2.0-0019810890 | en_US |
dc.identifier.volume | 13 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 244 | en_US |
dc.identifier.epage | 247 | en_US |
dc.identifier.scopusauthorid | Annibale, B=7005102706 | en_US |
dc.identifier.scopusauthorid | Bruzzone, R=7006793327 | en_US |
dc.identifier.scopusauthorid | Severi, C=6604099156 | en_US |
dc.identifier.issnl | 0392-0623 | - |