File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Meta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorder

TitleMeta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorder
Authors
KeywordsBipolar disorder
magnetic resonance imaging
mania
meta-analysis
Issue Date2004
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
Citation
Biological Psychiatry, 2004, v. 56 n. 6, p. 411-417 How to Cite?
AbstractSeveral studies assessing volumetric measurements of regional brain structure in bipolar disorder have been published in recent years, but their results have been inconsistent. Our aim was to complete a meta-analysis of regional morphometry in bipolar disorder as assessed using magnetic resonance imaging (MRI). We conducted a systematic literature search of MRI studies of bipolar disorder and identified studies which reported volume measurements in a selected number of regions. Twenty-six studies comprising volumetric measurements on up to 404 independent patients with bipolar disorder were included. A meta-analysis was carried out comparing the volumes of regions in bipolar disorder to comparison subjects using a random effects model. Patients with bipolar disorder had enlargement of the right lateral ventricle, but no other regional volumetric deviations which reached significance. Strong heterogeneity existed for several regions, including the third ventricle, left subgenual prefrontal cortex, bilateral amygdala and thalamus. Regional volume of most structures we studied is preserved in bipolar disorder as a whole, which was significantly associated only with right-sided ventricular enlargement. However the extensive heterogeneity detected indicates the need for further studies to establish if consistent regional brain volume deviation exists in bipolar disorder or in specific clinical subsets of the illness.
Persistent Identifierhttp://hdl.handle.net/10722/175972
ISSN
2023 Impact Factor: 9.6
2023 SCImago Journal Rankings: 3.786
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMcdonald, Cen_US
dc.contributor.authorZanelli, Jen_US
dc.contributor.authorRabeHesketh, Sen_US
dc.contributor.authorEllisonWright, Ien_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorKalidindi, Sen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorKennedy, Nen_US
dc.date.accessioned2012-11-26T09:03:08Z-
dc.date.available2012-11-26T09:03:08Z-
dc.date.issued2004en_US
dc.identifier.citationBiological Psychiatry, 2004, v. 56 n. 6, p. 411-417en_US
dc.identifier.issn0006-3223en_US
dc.identifier.urihttp://hdl.handle.net/10722/175972-
dc.description.abstractSeveral studies assessing volumetric measurements of regional brain structure in bipolar disorder have been published in recent years, but their results have been inconsistent. Our aim was to complete a meta-analysis of regional morphometry in bipolar disorder as assessed using magnetic resonance imaging (MRI). We conducted a systematic literature search of MRI studies of bipolar disorder and identified studies which reported volume measurements in a selected number of regions. Twenty-six studies comprising volumetric measurements on up to 404 independent patients with bipolar disorder were included. A meta-analysis was carried out comparing the volumes of regions in bipolar disorder to comparison subjects using a random effects model. Patients with bipolar disorder had enlargement of the right lateral ventricle, but no other regional volumetric deviations which reached significance. Strong heterogeneity existed for several regions, including the third ventricle, left subgenual prefrontal cortex, bilateral amygdala and thalamus. Regional volume of most structures we studied is preserved in bipolar disorder as a whole, which was significantly associated only with right-sided ventricular enlargement. However the extensive heterogeneity detected indicates the need for further studies to establish if consistent regional brain volume deviation exists in bipolar disorder or in specific clinical subsets of the illness.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiaten_US
dc.relation.ispartofBiological Psychiatryen_US
dc.subjectBipolar disorder-
dc.subjectmagnetic resonance imaging-
dc.subjectmania-
dc.subjectmeta-analysis-
dc.subject.meshAlgorithmsen_US
dc.subject.meshBipolar Disorder - Pathologyen_US
dc.subject.meshBrain - Pathologyen_US
dc.subject.meshBrain Mappingen_US
dc.subject.meshFunctional Lateralityen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshThird Ventricle - Pathologyen_US
dc.titleMeta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorderen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.biopsych.2004.06.021en_US
dc.identifier.pmid15364039-
dc.identifier.scopuseid_2-s2.0-4444377946en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4444377946&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume56en_US
dc.identifier.issue6en_US
dc.identifier.spage411en_US
dc.identifier.epage417en_US
dc.identifier.isiWOS:000223855200006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMcDonald, C=8749594800en_US
dc.identifier.scopusauthoridZanelli, J=9337612400en_US
dc.identifier.scopusauthoridRabeHesketh, S=7003779088en_US
dc.identifier.scopusauthoridEllisonWright, I=6507610262en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridKalidindi, S=24366595400en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridKennedy, N=7101730414en_US
dc.identifier.issnl0006-3223-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats