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- Publisher Website: 10.1016/j.neures.2006.10.002
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- PMID: 17113175
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Article: Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia
Title | Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia |
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Authors | |
Keywords | Chinese CHRFAM7A CHRNA7 Haplotype association Linkage disequilibrium analysis Polymorphism Schizophrenia |
Issue Date | 2007 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures |
Citation | Neuroscience Research, 2007, v. 57 n. 2, p. 194-202 How to Cite? |
Abstract | Several previous studies have reported a significant linkage between markers in the alpha 7 nicotinic cholinergic receptor subunit (CHRNA7) gene and either schizophrenia or the P50 sensory gating deficit, a schizophrenia endophenotype. However, CHRFAM7A, a partially duplicated gene 1.6 Mb upstream of the CHRNA7 gene, has complicated further genetic analysis. We genotyped 14 polymorphic markers throughout the full-length CHRNA7 gene and the duplicated region in 188 unrelated Han Chinese patients with schizophrenia and 188 controls. The duplicated regions were assessed by genotyping up- and down-stream polymorphic markers in the vicinity of each region and analyzing the linkage disequilibrium (LD) between each pair of markers. No evidence of risk variants for schizophrenia in either the CHRNA7 gene or the partially duplicated region was found in the LD analysis. A significant deviation from the Hardy-Weinberg equilibrium (HWE) was found only in the genotypic distribution of SNP9 (IVS4-1912) in patients (p = 0.00829), but not in controls. In conclusion, our LD analysis did not reveal any association between schizophrenia in our Han Chinese population and the CHRNA7 gene or its partially duplicated region. However, we could not exclude the possibility of a weak genetic effect due to the small sample size. Analyses of larger samples and higher-density markers, particularly around SNP9 (IVS4-1912), are still needed. © 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. |
Persistent Identifier | http://hdl.handle.net/10722/175963 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.811 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Iwata, Y | en_US |
dc.contributor.author | Nakajima, M | en_US |
dc.contributor.author | Yamada, K | en_US |
dc.contributor.author | Nakamura, K | en_US |
dc.contributor.author | Sekine, Y | en_US |
dc.contributor.author | Tsuchiya, KJ | en_US |
dc.contributor.author | Sugihara, G | en_US |
dc.contributor.author | Matsuzaki, H | en_US |
dc.contributor.author | Suda, S | en_US |
dc.contributor.author | Suzuki, K | en_US |
dc.contributor.author | Takei, N | en_US |
dc.contributor.author | Mori, N | en_US |
dc.contributor.author | Iwayama, Y | en_US |
dc.contributor.author | Takao, H | en_US |
dc.contributor.author | Yoshikawa, T | en_US |
dc.contributor.author | Riley, B | en_US |
dc.contributor.author | Makoff, A | en_US |
dc.contributor.author | Sham, P | en_US |
dc.contributor.author | Chen, R | en_US |
dc.contributor.author | Collier, D | en_US |
dc.date.accessioned | 2012-11-26T09:03:02Z | - |
dc.date.available | 2012-11-26T09:03:02Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Neuroscience Research, 2007, v. 57 n. 2, p. 194-202 | en_US |
dc.identifier.issn | 0168-0102 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175963 | - |
dc.description.abstract | Several previous studies have reported a significant linkage between markers in the alpha 7 nicotinic cholinergic receptor subunit (CHRNA7) gene and either schizophrenia or the P50 sensory gating deficit, a schizophrenia endophenotype. However, CHRFAM7A, a partially duplicated gene 1.6 Mb upstream of the CHRNA7 gene, has complicated further genetic analysis. We genotyped 14 polymorphic markers throughout the full-length CHRNA7 gene and the duplicated region in 188 unrelated Han Chinese patients with schizophrenia and 188 controls. The duplicated regions were assessed by genotyping up- and down-stream polymorphic markers in the vicinity of each region and analyzing the linkage disequilibrium (LD) between each pair of markers. No evidence of risk variants for schizophrenia in either the CHRNA7 gene or the partially duplicated region was found in the LD analysis. A significant deviation from the Hardy-Weinberg equilibrium (HWE) was found only in the genotypic distribution of SNP9 (IVS4-1912) in patients (p = 0.00829), but not in controls. In conclusion, our LD analysis did not reveal any association between schizophrenia in our Han Chinese population and the CHRNA7 gene or its partially duplicated region. However, we could not exclude the possibility of a weak genetic effect due to the small sample size. Analyses of larger samples and higher-density markers, particularly around SNP9 (IVS4-1912), are still needed. © 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures | en_US |
dc.relation.ispartof | Neuroscience Research | en_US |
dc.rights | Neuroscience Research. Copyright © Elsevier Ireland Ltd. | - |
dc.subject | Chinese | - |
dc.subject | CHRFAM7A | - |
dc.subject | CHRNA7 | - |
dc.subject | Haplotype association | - |
dc.subject | Linkage disequilibrium analysis | - |
dc.subject | Polymorphism | - |
dc.subject | Schizophrenia | - |
dc.subject.mesh | Asian Continental Ancestry Group - Ethnology | en_US |
dc.subject.mesh | Chi-Square Distribution | en_US |
dc.subject.mesh | Gene Frequency | en_US |
dc.subject.mesh | Genetic Predisposition To Disease | en_US |
dc.subject.mesh | Genotype | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Linkage Disequilibrium | en_US |
dc.subject.mesh | Polymorphism, Genetic | en_US |
dc.subject.mesh | Receptors, Nicotinic - Genetics | en_US |
dc.subject.mesh | Schizophrenia - Genetics | en_US |
dc.title | Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, P: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, P=rp00459 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.neures.2006.10.002 | en_US |
dc.identifier.pmid | 17113175 | - |
dc.identifier.scopus | eid_2-s2.0-33846685488 | en_US |
dc.identifier.hkuros | 133090 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33846685488&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 57 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 194 | en_US |
dc.identifier.epage | 202 | en_US |
dc.identifier.isi | WOS:000244575200004 | - |
dc.publisher.place | Ireland | en_US |
dc.identifier.scopusauthorid | Iwata, Y=7202730104 | en_US |
dc.identifier.scopusauthorid | Nakajima, M=15754128900 | en_US |
dc.identifier.scopusauthorid | Yamada, K=7405389843 | en_US |
dc.identifier.scopusauthorid | Nakamura, K=7406773797 | en_US |
dc.identifier.scopusauthorid | Sekine, Y=7201681655 | en_US |
dc.identifier.scopusauthorid | Tsuchiya, KJ=8567495200 | en_US |
dc.identifier.scopusauthorid | Sugihara, G=14036448600 | en_US |
dc.identifier.scopusauthorid | Matsuzaki, H=7202461913 | en_US |
dc.identifier.scopusauthorid | Suda, S=15046113400 | en_US |
dc.identifier.scopusauthorid | Suzuki, K=7501778438 | en_US |
dc.identifier.scopusauthorid | Takei, N=7102701392 | en_US |
dc.identifier.scopusauthorid | Mori, N=7402512072 | en_US |
dc.identifier.scopusauthorid | Iwayama, Y=8720196000 | en_US |
dc.identifier.scopusauthorid | Takao, H=8683253900 | en_US |
dc.identifier.scopusauthorid | Yoshikawa, T=7402717943 | en_US |
dc.identifier.scopusauthorid | Riley, B=7004434002 | en_US |
dc.identifier.scopusauthorid | Makoff, A=7006063526 | en_US |
dc.identifier.scopusauthorid | Sham, P=34573429300 | en_US |
dc.identifier.scopusauthorid | Chen, R=16635066600 | en_US |
dc.identifier.scopusauthorid | Collier, D=26642980600 | en_US |
dc.identifier.issnl | 0168-0102 | - |