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Article: Analysis of a structural polymorphism in the 5-HT(2A) receptor and clinical response to clozapine

TitleAnalysis of a structural polymorphism in the 5-HT(2A) receptor and clinical response to clozapine
Authors
Arranz, MJCollier, DAMunro, JSham, PKirov, GSodhi, MRoberts, GPrice, JKerwin, RW
KeywordsAntipsychotic
Clozapine
Serotonin
Issue Date1996
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1996, v. 217 n. 2-3, p. 177-178 How to Cite?
DOI: http://dx.doi.org/10.1016/0304-3940(96)13094-9
AbstractClozapine is an atypical antipsychotic with affinity for a broad range of receptors, including serotonin (5-HT) and dopamine receptors. It is successful in treating about 60% of patients refractory to other antipsychotic drugs. Since genetic variation in clozapine's neurotransmitter receptor targets may affect clinical response through altering drug binding or receptor expression, we have studied a His452Tyr polymorphism in the 5-HT(2A) receptor (HTR2A) in a sample of 153 schizophrenic patients undergoing clozapine treatment and 178 normal controls. An association was found between the allele Tyr452 and poor clinical response.
Persistent Identifierhttp://hdl.handle.net/10722/175766
ISSN
0304-3940
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.745
ISI Accession Number ID
WOS:A1996VQ39800027
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorArranz, MJen_US
dc.contributor.authorCollier, DAen_US
dc.contributor.authorMunro, Jen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorKirov, Gen_US
dc.contributor.authorSodhi, Men_US
dc.contributor.authorRoberts, Gen_US
dc.contributor.authorPrice, Jen_US
dc.contributor.authorKerwin, RWen_US
dc.date.accessioned2012-11-26T09:01:08Z-
dc.date.available2012-11-26T09:01:08Z-
dc.date.issued1996en_US
dc.identifier.citationNeuroscience Letters, 1996, v. 217 n. 2-3, p. 177-178en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/175766-
dc.description.abstractClozapine is an atypical antipsychotic with affinity for a broad range of receptors, including serotonin (5-HT) and dopamine receptors. It is successful in treating about 60% of patients refractory to other antipsychotic drugs. Since genetic variation in clozapine's neurotransmitter receptor targets may affect clinical response through altering drug binding or receptor expression, we have studied a His452Tyr polymorphism in the 5-HT(2A) receptor (HTR2A) in a sample of 153 schizophrenic patients undergoing clozapine treatment and 178 normal controls. An association was found between the allele Tyr452 and poor clinical response.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subjectAntipsychotic-
dc.subjectClozapine-
dc.subjectSerotonin-
dc.subject.meshAllelesen_US
dc.subject.meshAntipsychotic Agents - Pharmacology - Therapeutic Useen_US
dc.subject.meshClozapine - Pharmacology - Therapeutic Useen_US
dc.subject.meshDna - Analysisen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.subject.meshReceptors, Serotonin - Geneticsen_US
dc.subject.meshSchizophrenia - Drug Therapy - Geneticsen_US
dc.titleAnalysis of a structural polymorphism in the 5-HT(2A) receptor and clinical response to clozapineen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0304-3940(96)13094-9en_US
dc.identifier.pmid8916101-
dc.identifier.scopuseid_2-s2.0-0030592571en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030592571&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume217en_US
dc.identifier.issue2-3en_US
dc.identifier.spage177en_US
dc.identifier.epage178en_US
dc.identifier.isiWOS:A1996VQ39800027-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridArranz, MJ=7006010757en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US
dc.identifier.scopusauthoridMunro, J=7102726057en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridKirov, G=26643478800en_US
dc.identifier.scopusauthoridSodhi, M=7004463507en_US
dc.identifier.scopusauthoridRoberts, G=7403400681en_US
dc.identifier.scopusauthoridPrice, J=7404020184en_US
dc.identifier.scopusauthoridKerwin, RW=7102904567en_US
dc.identifier.issnl0304-3940-

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