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- Publisher Website: 10.1002/path.1711340304
- Scopus: eid_2-s2.0-0019495222
- PMID: 6790685
- WOS: WOS:A1981MD14400003
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Article: Hypersecretion of mucus glycoprotein by the gallbladder epithelium in experimental cholelithiasis
Title | Hypersecretion of mucus glycoprotein by the gallbladder epithelium in experimental cholelithiasis |
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Authors | |
Issue Date | 1981 |
Publisher | John Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130 |
Citation | Journal Of Pathology, 1981, v. 134 n. 3, p. 199-207 How to Cite? |
Abstract | In three models of cholelithiasis (dihydrocholesterol-fed rabbits, cholesterol-cholic acid-fed mice, and Lincomycin-treated guinea pig), the quantity and chemical composition of gallbladder epithelial mucin have been studied using (1) a spectrum of histochemical glycoprotein stains, and (2) biochemical extraction, purification and analysis of the carbohydrate components of epithelial mucin. Despite the diverse mechanism of stone induction and difference in stone composition, a common pattern of response by the epithelial mucin was observed in all three models. There was a quantitative increase in epithelial mucus production at a time before stones were formed and this increase persisted till stones were formed. There was no difference, qualitatively, between mucus produced by normal and stone-forming gallbladders. |
Persistent Identifier | http://hdl.handle.net/10722/175619 |
ISSN | 2023 Impact Factor: 5.6 2023 SCImago Journal Rankings: 2.426 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lee, SP | en_US |
dc.date.accessioned | 2012-11-26T09:00:09Z | - |
dc.date.available | 2012-11-26T09:00:09Z | - |
dc.date.issued | 1981 | en_US |
dc.identifier.citation | Journal Of Pathology, 1981, v. 134 n. 3, p. 199-207 | en_US |
dc.identifier.issn | 0022-3417 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175619 | - |
dc.description.abstract | In three models of cholelithiasis (dihydrocholesterol-fed rabbits, cholesterol-cholic acid-fed mice, and Lincomycin-treated guinea pig), the quantity and chemical composition of gallbladder epithelial mucin have been studied using (1) a spectrum of histochemical glycoprotein stains, and (2) biochemical extraction, purification and analysis of the carbohydrate components of epithelial mucin. Despite the diverse mechanism of stone induction and difference in stone composition, a common pattern of response by the epithelial mucin was observed in all three models. There was a quantitative increase in epithelial mucus production at a time before stones were formed and this increase persisted till stones were formed. There was no difference, qualitatively, between mucus produced by normal and stone-forming gallbladders. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130 | en_US |
dc.relation.ispartof | Journal of Pathology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cholelithiasis - Chemically Induced - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Cholestanol | en_US |
dc.subject.mesh | Cholesterol | en_US |
dc.subject.mesh | Cholic Acids | en_US |
dc.subject.mesh | Disease Models, Animal | en_US |
dc.subject.mesh | Epithelium - Analysis - Secretion | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gallbladder - Analysis - Secretion | en_US |
dc.subject.mesh | Glycoproteins - Analysis - Secretion | en_US |
dc.subject.mesh | Guinea Pigs | en_US |
dc.subject.mesh | Histocytochemistry | en_US |
dc.subject.mesh | Lincomycin | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Mucus - Analysis - Secretion | en_US |
dc.subject.mesh | Rabbits | en_US |
dc.title | Hypersecretion of mucus glycoprotein by the gallbladder epithelium in experimental cholelithiasis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, SP: sumlee@hku.hk | en_US |
dc.identifier.authority | Lee, SP=rp01351 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/path.1711340304 | - |
dc.identifier.pmid | 6790685 | - |
dc.identifier.scopus | eid_2-s2.0-0019495222 | en_US |
dc.identifier.volume | 134 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 199 | en_US |
dc.identifier.epage | 207 | en_US |
dc.identifier.isi | WOS:A1981MD14400003 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Lee, SP=7601417497 | en_US |
dc.identifier.issnl | 0022-3417 | - |