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- Publisher Website: 10.1126/science.7466399
- Scopus: eid_2-s2.0-0019433910
- PMID: 7466399
- WOS: WOS:A1981LG07300030
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Article: Aspirin prevention of cholesterol gallstone formation in prairie dogs
Title | Aspirin prevention of cholesterol gallstone formation in prairie dogs |
---|---|
Authors | |
Issue Date | 1981 |
Publisher | American Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org |
Citation | Science, 1981, v. 211 n. 4489, p. 1429-1431 How to Cite? |
Abstract | When prairie dogs (Cynomys ludovicianus) are fed a diet containing cholesterol, a marked increase in gallbladder mucin secretion parallels the evolution of cholesterol supersaturated bile. Gelation of mucin precedes the precipitation of cholesterol liquid and solid crystals and the development of gallstones. Aspirin given to prairie dogs inhibited mucin hypersecretion and gel accumulation and prevented gallstone formation without influencing the cholesterol content of supersaturated bile. This suggests that gallbladder mucin is a nucleation matrix for cholesterol gallstones. |
Persistent Identifier | http://hdl.handle.net/10722/175618 |
ISSN | 2023 Impact Factor: 44.7 2023 SCImago Journal Rankings: 11.902 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, SP | en_US |
dc.contributor.author | Carey, MC | en_US |
dc.contributor.author | Lamont, JT | en_US |
dc.date.accessioned | 2012-11-26T09:00:09Z | - |
dc.date.available | 2012-11-26T09:00:09Z | - |
dc.date.issued | 1981 | en_US |
dc.identifier.citation | Science, 1981, v. 211 n. 4489, p. 1429-1431 | en_US |
dc.identifier.issn | 0036-8075 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175618 | - |
dc.description.abstract | When prairie dogs (Cynomys ludovicianus) are fed a diet containing cholesterol, a marked increase in gallbladder mucin secretion parallels the evolution of cholesterol supersaturated bile. Gelation of mucin precedes the precipitation of cholesterol liquid and solid crystals and the development of gallstones. Aspirin given to prairie dogs inhibited mucin hypersecretion and gel accumulation and prevented gallstone formation without influencing the cholesterol content of supersaturated bile. This suggests that gallbladder mucin is a nucleation matrix for cholesterol gallstones. | en_US |
dc.language | eng | en_US |
dc.publisher | American Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org | en_US |
dc.relation.ispartof | Science | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Aspirin - Pharmacology - Therapeutic Use | en_US |
dc.subject.mesh | Bile - Analysis | en_US |
dc.subject.mesh | Cholelithiasis - Metabolism - Prevention & Control | en_US |
dc.subject.mesh | Cholesterol, Dietary - Metabolism | en_US |
dc.subject.mesh | Crystallization | en_US |
dc.subject.mesh | Culture Techniques | en_US |
dc.subject.mesh | Gallbladder - Secretion | en_US |
dc.subject.mesh | Lipids - Analysis | en_US |
dc.subject.mesh | Mucins - Secretion | en_US |
dc.subject.mesh | Sciuridae | en_US |
dc.subject.mesh | Secretory Rate - Drug Effects | en_US |
dc.title | Aspirin prevention of cholesterol gallstone formation in prairie dogs | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, SP: sumlee@hku.hk | en_US |
dc.identifier.authority | Lee, SP=rp01351 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1126/science.7466399 | - |
dc.identifier.pmid | 7466399 | - |
dc.identifier.scopus | eid_2-s2.0-0019433910 | en_US |
dc.identifier.volume | 211 | en_US |
dc.identifier.issue | 4489 | en_US |
dc.identifier.spage | 1429 | en_US |
dc.identifier.epage | 1431 | en_US |
dc.identifier.isi | WOS:A1981LG07300030 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lee, SP=7601417497 | en_US |
dc.identifier.scopusauthorid | Carey, MC=7202744540 | en_US |
dc.identifier.scopusauthorid | LaMont, JT=7103091181 | en_US |
dc.identifier.issnl | 0036-8075 | - |