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- Publisher Website: 10.1002/path.1711310204
- Scopus: eid_2-s2.0-0018821215
- PMID: 7431143
- WOS: WOS:A1980KB86400003
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Article: Further observations in lincomycin-induced cholelithiasis in guinea-pigs
Title | Further observations in lincomycin-induced cholelithiasis in guinea-pigs |
---|---|
Authors | |
Issue Date | 1980 |
Publisher | John Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130 |
Citation | Journal Of Pathology, 1980, v. 131 n. 2, p. 117-125 How to Cite? |
Abstract | Further experiments are reported on Lincomycin-induced cholelithiasis in guinea-pigs. The biochemical events in the bile and blood, and the chemical composition of gallstones, have been studied. The gallstones resemble human pigment stones in chemical composition. the clear hepatic bile and the normality of the bile salt-phospholipid-cholesterol equilibrium, the rise in β-glucuronidase and hexosamine levels with the gallbladder, have reaffirmed that epithelial injury is most probably the primary lithogenic factor. Ligation of the cystic duct and the construction of a common hepatic duct-duodenum bypass did not prevent the development of acute cholecystitis, suggesting the lithogenic factor was mediated through the blood circulation and not through the enterohepatic circulation of bile. |
Persistent Identifier | http://hdl.handle.net/10722/175611 |
ISSN | 2023 Impact Factor: 5.6 2023 SCImago Journal Rankings: 2.426 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, SP | en_US |
dc.contributor.author | Scott, AJ | en_US |
dc.date.accessioned | 2012-11-26T09:00:08Z | - |
dc.date.available | 2012-11-26T09:00:08Z | - |
dc.date.issued | 1980 | en_US |
dc.identifier.citation | Journal Of Pathology, 1980, v. 131 n. 2, p. 117-125 | en_US |
dc.identifier.issn | 0022-3417 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175611 | - |
dc.description.abstract | Further experiments are reported on Lincomycin-induced cholelithiasis in guinea-pigs. The biochemical events in the bile and blood, and the chemical composition of gallstones, have been studied. The gallstones resemble human pigment stones in chemical composition. the clear hepatic bile and the normality of the bile salt-phospholipid-cholesterol equilibrium, the rise in β-glucuronidase and hexosamine levels with the gallbladder, have reaffirmed that epithelial injury is most probably the primary lithogenic factor. Ligation of the cystic duct and the construction of a common hepatic duct-duodenum bypass did not prevent the development of acute cholecystitis, suggesting the lithogenic factor was mediated through the blood circulation and not through the enterohepatic circulation of bile. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130 | en_US |
dc.relation.ispartof | Journal of Pathology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bile - Analysis | en_US |
dc.subject.mesh | Cholelithiasis - Chemically Induced - Metabolism - Pathology | en_US |
dc.subject.mesh | Colitis - Pathology | en_US |
dc.subject.mesh | Disease Models, Animal | en_US |
dc.subject.mesh | Enterohepatic Circulation | en_US |
dc.subject.mesh | Erythrocytes - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Glucuronidase - Metabolism | en_US |
dc.subject.mesh | Guinea Pigs | en_US |
dc.subject.mesh | Hexosamines - Metabolism | en_US |
dc.subject.mesh | Ileitis - Pathology | en_US |
dc.subject.mesh | Lincomycin - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.title | Further observations in lincomycin-induced cholelithiasis in guinea-pigs | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, SP: sumlee@hku.hk | en_US |
dc.identifier.authority | Lee, SP=rp01351 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/path.1711310204 | - |
dc.identifier.pmid | 7431143 | - |
dc.identifier.scopus | eid_2-s2.0-0018821215 | en_US |
dc.identifier.volume | 131 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 117 | en_US |
dc.identifier.epage | 125 | en_US |
dc.identifier.isi | WOS:A1980KB86400003 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Lee, SP=7601417497 | en_US |
dc.identifier.scopusauthorid | Scott, AJ=7403271310 | en_US |
dc.identifier.issnl | 0022-3417 | - |