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Article: Effect of cimetidine on the healing of restraint-induced gastric erosions in the rat

TitleEffect of cimetidine on the healing of restraint-induced gastric erosions in the rat
Authors
Lee, SPClarke, ACTasmanJones, C
Keywordsacid secretion
gastric erosion
histamine antagonist
rat
Issue Date1978
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1978, v. 5 n. 4, p. 383-385 How to Cite?
DOI: http://dx.doi.org/10.1111/j.1440-1681.1978.tb00687.x
AbstractRats after a 24 h restraint developed acute gastric erosions. Cimetidine in a dose of 100 mg/kg body weight was given subcutaneously every 8 h to a group of 150 rats after restraint. A second group received saline subcutaneously (placebo group). Erosions in the placebo group required up to 45 days to heal (median healing time approximately 24 days). Cimetidine treatment reduced the median healing time to approximately 12 days. Cimetidine in this dose promotes healing of acute gastric erosions in the rat induced by restraint.
Persistent Identifierhttp://hdl.handle.net/10722/175603
ISSN
0305-1870
2022 Impact Factor: 2.9
2020 SCImago Journal Rankings: 0.752
ISI Accession Number ID
WOS:A1978FP29200010

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.contributor.authorClarke, ACen_US
dc.contributor.authorTasmanJones, Cen_US
dc.date.accessioned2012-11-26T09:00:06Z-
dc.date.available2012-11-26T09:00:06Z-
dc.date.issued1978en_US
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1978, v. 5 n. 4, p. 383-385en_US
dc.identifier.issn0305-1870en_US
dc.identifier.urihttp://hdl.handle.net/10722/175603-
dc.description.abstractRats after a 24 h restraint developed acute gastric erosions. Cimetidine in a dose of 100 mg/kg body weight was given subcutaneously every 8 h to a group of 150 rats after restraint. A second group received saline subcutaneously (placebo group). Erosions in the placebo group required up to 45 days to heal (median healing time approximately 24 days). Cimetidine treatment reduced the median healing time to approximately 12 days. Cimetidine in this dose promotes healing of acute gastric erosions in the rat induced by restraint.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.subjectacid secretion-
dc.subjectgastric erosion-
dc.subjecthistamine antagonist-
dc.subjectrat-
dc.subject.meshAnimalsen_US
dc.subject.meshCimetidine - Therapeutic Useen_US
dc.subject.meshGuanidines - Therapeutic Useen_US
dc.subject.meshMaleen_US
dc.subject.meshPlacebosen_US
dc.subject.meshRatsen_US
dc.subject.meshRestraint, Physicalen_US
dc.subject.meshStomach Ulcer - Drug Therapy - Etiologyen_US
dc.subject.meshTime Factorsen_US
dc.titleEffect of cimetidine on the healing of restraint-induced gastric erosions in the raten_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1681.1978.tb00687.x-
dc.identifier.pmid699381-
dc.identifier.scopuseid_2-s2.0-0018069375en_US
dc.identifier.volume5en_US
dc.identifier.issue4en_US
dc.identifier.spage383en_US
dc.identifier.epage385en_US
dc.identifier.isiWOS:A1978FP29200010-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridClarke, AC=7403682654en_US
dc.identifier.scopusauthoridTasmanJones, C=7003303326en_US
dc.identifier.issnl0305-1870-

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