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Article: Determination of ziprasidone hydrochloride by RP-HPLC with UV detection

TitleDetermination of ziprasidone hydrochloride by RP-HPLC with UV detection
Authors
Li, NShen, SZhong, YWang, ZYYu, YQ
KeywordsHigh Performance Liquid Chromatography
Quantitative Analysis
Ziprasidone Hydrochloride
Issue Date2004
Citation
Fudan University Journal Of Medical Sciences, 2004, v. 31 n. 6, p. 656-657 How to Cite?
AbstractPurpose: To establish an RP-HPLC method for the determination of Ziprasidone hydrochloride. Methods: A C18 (4.6 mm x 150 mm, 5 μm) column was adopted as stationary phase, Methanol-50 mmol/L sodium acetate solution (adjustment of pH to 6.0 with acetic acid) (75:25, V/V) was used as mobile phase, the flow rate was 1.2 mL/min, the detection wavelength was 254 nm, and the temperature of column was 25°C. Results: The limit of detection for Ziprasidone hydrochloride was 10.10 ng, the linearity was good at the range of 1.010-1010 μg/mL, R = 1.000. The intra-day and inter-day RSD of ziprasidone hydrochloride were both lower than 2%. Conclusions: The established method was simple, sensitive and accurate,and can be used for the determination and quality control of ziprasidone hydrochloride.
Persistent Identifierhttp://hdl.handle.net/10722/174921
ISSN
1672-8467
2023 SCImago Journal Rankings: 0.117
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLi, Nen_US
dc.contributor.authorShen, Sen_US
dc.contributor.authorZhong, Yen_US
dc.contributor.authorWang, ZYen_US
dc.contributor.authorYu, YQen_US
dc.date.accessioned2012-11-26T08:48:08Z-
dc.date.available2012-11-26T08:48:08Z-
dc.date.issued2004en_US
dc.identifier.citationFudan University Journal Of Medical Sciences, 2004, v. 31 n. 6, p. 656-657en_US
dc.identifier.issn1672-8467en_US
dc.identifier.urihttp://hdl.handle.net/10722/174921-
dc.description.abstractPurpose: To establish an RP-HPLC method for the determination of Ziprasidone hydrochloride. Methods: A C18 (4.6 mm x 150 mm, 5 μm) column was adopted as stationary phase, Methanol-50 mmol/L sodium acetate solution (adjustment of pH to 6.0 with acetic acid) (75:25, V/V) was used as mobile phase, the flow rate was 1.2 mL/min, the detection wavelength was 254 nm, and the temperature of column was 25°C. Results: The limit of detection for Ziprasidone hydrochloride was 10.10 ng, the linearity was good at the range of 1.010-1010 μg/mL, R = 1.000. The intra-day and inter-day RSD of ziprasidone hydrochloride were both lower than 2%. Conclusions: The established method was simple, sensitive and accurate,and can be used for the determination and quality control of ziprasidone hydrochloride.en_US
dc.languageengen_US
dc.relation.ispartofFudan University Journal of Medical Sciencesen_US
dc.subjectHigh Performance Liquid Chromatographyen_US
dc.subjectQuantitative Analysisen_US
dc.subjectZiprasidone Hydrochlorideen_US
dc.titleDetermination of ziprasidone hydrochloride by RP-HPLC with UV detectionen_US
dc.typeArticleen_US
dc.identifier.emailShen, S: sshen@hkucc.hku.hken_US
dc.identifier.authorityShen, S=rp00775en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-12344249759en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12344249759&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume31en_US
dc.identifier.issue6en_US
dc.identifier.spage656en_US
dc.identifier.epage657en_US
dc.identifier.scopusauthoridLi, N=27170796800en_US
dc.identifier.scopusauthoridShen, S=7403431266en_US
dc.identifier.scopusauthoridZhong, Y=36488828400en_US
dc.identifier.scopusauthoridWang, ZY=8583246400en_US
dc.identifier.scopusauthoridYu, YQ=8572872900en_US
dc.identifier.issnl1672-8467-

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