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Conference Paper: Third pathway: Endothelium-dependent hyperpolarization
Title | Third pathway: Endothelium-dependent hyperpolarization |
---|---|
Authors | |
Keywords | Blood Vessel Endothelium Potassium Channel Smooth Muscle Vasodilatation |
Issue Date | 2003 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34597 |
Citation | Drug Development Research, 2003, v. 58 n. 1, p. 18-22 How to Cite? |
Abstract | The mechanism of endothelium-dependent hyperpolarizations, once attributed to an elusive endothelium-derived hyperpolarizing factor (EDHF), is better understood. The first steps involve an increase in the intracellular calcium concentration of the endothelial cells followed by the opening of endothelial calcium-activated potassium channels and the hyperpolarization of the endothelial cells. In certain arteries, these endothelial events are under the control of the endothelial cytochrome P450 monooxygenase. Then, the endothelium-dependent hyperpolarization of the smooth muscle cells can be evoked by direct electrical coupling through myo-endothelial junctions, accumulation of potassium ions in the intracellular space between the endothelial and the smooth muscle cells, and in rare occasions the release of a metabolite(s) of arachidonic acid via the cytochrome P450 pathway. These various mechanisms are not necessarily exclusive and can occur simultaneously and even in synergy. © 2003 Wiley-Liss, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/173542 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 0.672 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Félétou, M | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:32:36Z | - |
dc.date.available | 2012-10-30T06:32:36Z | - |
dc.date.issued | 2003 | en_US |
dc.identifier.citation | Drug Development Research, 2003, v. 58 n. 1, p. 18-22 | en_US |
dc.identifier.issn | 0272-4391 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173542 | - |
dc.description.abstract | The mechanism of endothelium-dependent hyperpolarizations, once attributed to an elusive endothelium-derived hyperpolarizing factor (EDHF), is better understood. The first steps involve an increase in the intracellular calcium concentration of the endothelial cells followed by the opening of endothelial calcium-activated potassium channels and the hyperpolarization of the endothelial cells. In certain arteries, these endothelial events are under the control of the endothelial cytochrome P450 monooxygenase. Then, the endothelium-dependent hyperpolarization of the smooth muscle cells can be evoked by direct electrical coupling through myo-endothelial junctions, accumulation of potassium ions in the intracellular space between the endothelial and the smooth muscle cells, and in rare occasions the release of a metabolite(s) of arachidonic acid via the cytochrome P450 pathway. These various mechanisms are not necessarily exclusive and can occur simultaneously and even in synergy. © 2003 Wiley-Liss, Inc. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34597 | en_US |
dc.relation.ispartof | Drug Development Research | en_US |
dc.subject | Blood Vessel | en_US |
dc.subject | Endothelium | en_US |
dc.subject | Potassium Channel | en_US |
dc.subject | Smooth Muscle | en_US |
dc.subject | Vasodilatation | en_US |
dc.title | Third pathway: Endothelium-dependent hyperpolarization | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/ddr.10125 | en_US |
dc.identifier.scopus | eid_2-s2.0-0037282549 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0037282549&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 58 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 18 | en_US |
dc.identifier.epage | 22 | en_US |
dc.identifier.isi | WOS:000181384400003 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Félétou, M=7006461826 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0272-4391 | - |