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- Publisher Website: 10.1111/j.1471-0528.1983.tb08916.x
- Scopus: eid_2-s2.0-0020531885
- PMID: 6188478
- WOS: WOS:A1983QM95500006
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Article: Schwangerschaftsprotein 1 (SP1) in serum and cerebrospinal fluid of patients with gestational trophoblastic disease
Title | Schwangerschaftsprotein 1 (SP1) in serum and cerebrospinal fluid of patients with gestational trophoblastic disease |
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Authors | |
Issue Date | 1983 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOG |
Citation | British Journal Of Obstetrics And Gynaecology, 1983, v. 90 n. 4, p. 317-322 How to Cite? |
Abstract | The β subunit of human chorionic gonadotrophin (β-hCG) and Schwangerschaftsprotein 1 (SP1) were measured by radioimmunoassay in the serum and cerebrospinal fluid (CSF) of 46 postmolar and postpartum patients who developed gestational trophoblastic disease. There was a significant correlation between β-hCG and SP1 serum levels. The mean serum SP1 level in high-risk patients was significantly higher than that in low-risk patients. There was a significant correlation between serum and CSF β-hCG levels. The ratio of serum to CSF β-hCG levels was low in the 3 patients with clinical evidence of intracranial metastasis. SP1 was present in the CSF of only one of these 3 patients, but it could be detected in the CSF of another 4 patients without clinical evidence of metastases in the central nervous system. The 2 low-risk patients with SP1 present in the CSF showed poor response to intramuscular methotrexate. |
Persistent Identifier | http://hdl.handle.net/10722/173067 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ho, PC | en_US |
dc.contributor.author | Ma, HK | en_US |
dc.date.accessioned | 2012-10-30T06:27:48Z | - |
dc.date.available | 2012-10-30T06:27:48Z | - |
dc.date.issued | 1983 | en_US |
dc.identifier.citation | British Journal Of Obstetrics And Gynaecology, 1983, v. 90 n. 4, p. 317-322 | en_US |
dc.identifier.issn | 0306-5456 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173067 | - |
dc.description.abstract | The β subunit of human chorionic gonadotrophin (β-hCG) and Schwangerschaftsprotein 1 (SP1) were measured by radioimmunoassay in the serum and cerebrospinal fluid (CSF) of 46 postmolar and postpartum patients who developed gestational trophoblastic disease. There was a significant correlation between β-hCG and SP1 serum levels. The mean serum SP1 level in high-risk patients was significantly higher than that in low-risk patients. There was a significant correlation between serum and CSF β-hCG levels. The ratio of serum to CSF β-hCG levels was low in the 3 patients with clinical evidence of intracranial metastasis. SP1 was present in the CSF of only one of these 3 patients, but it could be detected in the CSF of another 4 patients without clinical evidence of metastases in the central nervous system. The 2 low-risk patients with SP1 present in the CSF showed poor response to intramuscular methotrexate. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOG | en_US |
dc.relation.ispartof | British Journal of Obstetrics and Gynaecology | en_US |
dc.subject.mesh | Brain Neoplasms - Secondary | en_US |
dc.subject.mesh | Chorionic Gonadotropin - Blood - Cerebrospinal Fluid | en_US |
dc.subject.mesh | Chorionic Gonadotropin, Beta Subunit, Human | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Peptide Fragments - Blood - Cerebrospinal Fluid | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pregnancy Proteins - Analysis | en_US |
dc.subject.mesh | Pregnancy-Specific Beta 1-Glycoproteins - Analysis - Cerebrospinal Fluid | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.subject.mesh | Trophoblastic Neoplasms - Blood - Cerebrospinal Fluid - Drug Therapy | en_US |
dc.subject.mesh | Uterine Neoplasms - Blood - Cerebrospinal Fluid - Drug Therapy | en_US |
dc.title | Schwangerschaftsprotein 1 (SP1) in serum and cerebrospinal fluid of patients with gestational trophoblastic disease | en_US |
dc.type | Article | en_US |
dc.identifier.email | Ho, PC:pcho@hku.hk | en_US |
dc.identifier.authority | Ho, PC=rp00325 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1471-0528.1983.tb08916.x | - |
dc.identifier.pmid | 6188478 | en_US |
dc.identifier.scopus | eid_2-s2.0-0020531885 | en_US |
dc.identifier.volume | 90 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 317 | en_US |
dc.identifier.epage | 322 | en_US |
dc.identifier.isi | WOS:A1983QM95500006 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Ho, PC=7402211440 | en_US |
dc.identifier.scopusauthorid | Ma, HK=7403095603 | en_US |
dc.identifier.issnl | 0306-5456 | - |