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- Publisher Website: 10.1016/j.ejvs.2012.06.004
- Scopus: eid_2-s2.0-84866941890
- PMID: 22835767
- WOS: WOS:000310412300009
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Article: Ex-vivo haemodynamic models for the study of Stanford type B aortic dissection in isolated porcine aorta
Title | Ex-vivo haemodynamic models for the study of Stanford type B aortic dissection in isolated porcine aorta |
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Authors | |
Keywords | Sodium chloride Animal experiment Aorta balloon Aorta dissection Ex vivo study |
Issue Date | 2012 |
Publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvs |
Citation | European Journal of Vascular and Endovascular Surgery, 2012, v. 44 n. 4, p. 399-405 How to Cite? |
Abstract | OBJECTIVES: The aim of this study is to present novel ex-vivo models in the study of complex haemodynamical changes in Stanford type B aortic dissection (TBAD). MATERIALS AND METHODS: Fifteen fresh porcine aortas were harvested and preserved with 4 degrees C saline. Ex-vivo models were developed to simulate TBAD in three different situations: model A with patent false lumen, model B with distal re-entry only and model C with proximal primary entry only. These models were connected to standardised pulsatile pumps and the pressure waveforms were monitored and compared. The aortas were scanned with ultrasonography and subjected to post-experiment autopsy. RESULTS: The three different models were successfully created (n = 13). Pulsatile flow testing was successful and the shapes of the pressure waveforms were similar to those taken from human aorta. Post-testing gross examination confirmed the success of modelling. CONCLUSION: Porcine aortas may prove to be useful ex-vivo models in the study of aortic dissection haemodynamics. These models are reproducible and may be used in the study of complex haemodynamic forces during the development and propagation of TBAD. Our three porcine models give a potential possibility in helping clinicians isolate and analyse complex haemodynamical factors in the development, propagation and prognosis of TBAD. |
Persistent Identifier | http://hdl.handle.net/10722/173037 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.330 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Qing, KX | en_US |
dc.contributor.author | Chan, YC | en_US |
dc.contributor.author | Lau, SF | en_US |
dc.contributor.author | Yiu, WK | en_US |
dc.contributor.author | Ting, ACW | en_US |
dc.contributor.author | Cheng, SWK | en_US |
dc.date.accessioned | 2012-10-30T06:26:50Z | - |
dc.date.available | 2012-10-30T06:26:50Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | European Journal of Vascular and Endovascular Surgery, 2012, v. 44 n. 4, p. 399-405 | en_US |
dc.identifier.issn | 1078-5884 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173037 | - |
dc.description.abstract | OBJECTIVES: The aim of this study is to present novel ex-vivo models in the study of complex haemodynamical changes in Stanford type B aortic dissection (TBAD). MATERIALS AND METHODS: Fifteen fresh porcine aortas were harvested and preserved with 4 degrees C saline. Ex-vivo models were developed to simulate TBAD in three different situations: model A with patent false lumen, model B with distal re-entry only and model C with proximal primary entry only. These models were connected to standardised pulsatile pumps and the pressure waveforms were monitored and compared. The aortas were scanned with ultrasonography and subjected to post-experiment autopsy. RESULTS: The three different models were successfully created (n = 13). Pulsatile flow testing was successful and the shapes of the pressure waveforms were similar to those taken from human aorta. Post-testing gross examination confirmed the success of modelling. CONCLUSION: Porcine aortas may prove to be useful ex-vivo models in the study of aortic dissection haemodynamics. These models are reproducible and may be used in the study of complex haemodynamic forces during the development and propagation of TBAD. Our three porcine models give a potential possibility in helping clinicians isolate and analyse complex haemodynamical factors in the development, propagation and prognosis of TBAD. | en_US |
dc.language | eng | en_US |
dc.publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvs | en_US |
dc.relation.ispartof | European Journal of Vascular and Endovascular Surgery | en_US |
dc.subject | Sodium chloride | en_US |
dc.subject | Animal experiment | en_US |
dc.subject | Aorta balloon | en_US |
dc.subject | Aorta dissection | en_US |
dc.subject | Ex vivo study | en_US |
dc.title | Ex-vivo haemodynamic models for the study of Stanford type B aortic dissection in isolated porcine aorta | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chan, YC: ycchan88@hkucc.hku.hk | en_US |
dc.identifier.email | Lau, SF: lausf@hku.hk | en_US |
dc.identifier.email | Yiu, WK: waikiyiu@hku.hk | - |
dc.identifier.email | Ting, ACW: tingacw@hku.hk | - |
dc.identifier.email | Cheng, SWK: wkcheng@hkucc.hku.hk | - |
dc.identifier.authority | Yiu, WK=rp00311 | en_US |
dc.identifier.authority | Cheng, SWK=rp00374 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.ejvs.2012.06.004 | en_US |
dc.identifier.pmid | 22835767 | - |
dc.identifier.scopus | eid_2-s2.0-84866941890 | en_US |
dc.identifier.hkuros | 212347 | - |
dc.identifier.volume | 44 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 399 | - |
dc.identifier.epage | 405 | - |
dc.identifier.eissn | 1532-2165 | - |
dc.identifier.isi | WOS:000310412300009 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Cheng, SWK=7404684779 | en_US |
dc.identifier.scopusauthorid | Ting, ACW=7102858552 | en_US |
dc.identifier.scopusauthorid | Yiu, WK=12763171700 | en_US |
dc.identifier.scopusauthorid | Lau, SF=55318361100 | en_US |
dc.identifier.scopusauthorid | Chan, YC=55226588600 | en_US |
dc.identifier.scopusauthorid | Qing, KX=36004840500 | en_US |
dc.identifier.issnl | 1078-5884 | - |