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- Publisher Website: 10.1046/j.1600-6143.2003.00313.x
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- PMID: 14974940
- WOS: WOS:000188644100008
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Article: Linking Inflammation to Acute Rejection in Small-for-Size Liver Allografts: The Potential Role of Early Macrophage Activation
Title | Linking Inflammation to Acute Rejection in Small-for-Size Liver Allografts: The Potential Role of Early Macrophage Activation |
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Authors | |
Keywords | Cellular response Inflammation Macrophage |
Issue Date | 2004 |
Publisher | Blackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AJT |
Citation | American Journal Of Transplantation, 2004, v. 4 n. 2, p. 196-209 How to Cite? |
Abstract | This study aims to investigate the immunological status of small-for-size liver allografts and possible mechanism that contributes to the accelerated immune response in these allografts. Eight experimental groups were: whole isografts; 40% isografts; whole allografts, no treatment; 40% allografts, no treatment; whole allografts with sodium salicylate intraperitoneal injection, D0-3; 40% allografts with sodium salicylate, D0-3; whole allografts with FK506 intramuscular injection D0-3, and 40% allografts with FK506, D0-3. The 40% allografts survived significantly shorter than whole allografts (p = 0.02). At 72 h after reperfusion, a higher number of macrophages infiltrated into the periportal area of small-for-size allografts than whole allografts. Remarkable up-regulation of interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-10 (IL-10) and interferon-γ (IFN-γ) messenger RNA (mRNA) levels were detected in small-for-size allografts within 24 h after reperfusion. Sodium salicylate administration reduced IL-1β and IFN-γ mRNA in both small-for-size and whole allografts, but it could decrease IL-2 and IL-10 mRNA levels only in small-for-size allografts. In vitro study revealed that CD80, CD86 and CD11b expression on macrophages was augmented after IL-1β stimulation, whereas the up-regulation could be blocked by sodium salicylate. In conclusion, early activation of macrophages as a result of graft injury might play an important role in the accelerated acute rejection process In small-for-size allografts. |
Persistent Identifier | http://hdl.handle.net/10722/172859 |
ISSN | 2023 Impact Factor: 8.9 2023 SCImago Journal Rankings: 2.688 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, ZF | en_HK |
dc.contributor.author | Ho, DWY | en_HK |
dc.contributor.author | Chu, ACY | en_HK |
dc.contributor.author | Wang, YQ | en_HK |
dc.contributor.author | Fan, ST | en_HK |
dc.date.accessioned | 2012-10-30T06:25:22Z | - |
dc.date.available | 2012-10-30T06:25:22Z | - |
dc.date.issued | 2004 | en_HK |
dc.identifier.citation | American Journal Of Transplantation, 2004, v. 4 n. 2, p. 196-209 | en_HK |
dc.identifier.issn | 1600-6135 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/172859 | - |
dc.description.abstract | This study aims to investigate the immunological status of small-for-size liver allografts and possible mechanism that contributes to the accelerated immune response in these allografts. Eight experimental groups were: whole isografts; 40% isografts; whole allografts, no treatment; 40% allografts, no treatment; whole allografts with sodium salicylate intraperitoneal injection, D0-3; 40% allografts with sodium salicylate, D0-3; whole allografts with FK506 intramuscular injection D0-3, and 40% allografts with FK506, D0-3. The 40% allografts survived significantly shorter than whole allografts (p = 0.02). At 72 h after reperfusion, a higher number of macrophages infiltrated into the periportal area of small-for-size allografts than whole allografts. Remarkable up-regulation of interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-10 (IL-10) and interferon-γ (IFN-γ) messenger RNA (mRNA) levels were detected in small-for-size allografts within 24 h after reperfusion. Sodium salicylate administration reduced IL-1β and IFN-γ mRNA in both small-for-size and whole allografts, but it could decrease IL-2 and IL-10 mRNA levels only in small-for-size allografts. In vitro study revealed that CD80, CD86 and CD11b expression on macrophages was augmented after IL-1β stimulation, whereas the up-regulation could be blocked by sodium salicylate. In conclusion, early activation of macrophages as a result of graft injury might play an important role in the accelerated acute rejection process In small-for-size allografts. | en_HK |
dc.language | eng | en_US |
dc.publisher | Blackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AJT | en_HK |
dc.relation.ispartof | American Journal of Transplantation | en_HK |
dc.subject | Cellular response | en_HK |
dc.subject | Inflammation | en_HK |
dc.subject | Macrophage | en_HK |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Graft Rejection - Immunology - Pathology | en_US |
dc.subject.mesh | Graft Survival - Drug Effects - Immunology | en_US |
dc.subject.mesh | Inflammation - Immunology - Pathology | en_US |
dc.subject.mesh | Liver - Anatomy & Histology | en_US |
dc.subject.mesh | Liver Transplantation - Immunology - Pathology | en_US |
dc.subject.mesh | Macrophage Activation - Immunology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Rna, Messenger - Genetics | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Lew | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Transplantation, Homologous | en_US |
dc.subject.mesh | Transplantation, Isogeneic | en_US |
dc.title | Linking Inflammation to Acute Rejection in Small-for-Size Liver Allografts: The Potential Role of Early Macrophage Activation | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Chu, ACY: bcccy@hkucc.hku.hk | en_HK |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_HK |
dc.identifier.authority | Chu, ACY=rp00505 | en_HK |
dc.identifier.authority | Fan, ST=rp00355 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1046/j.1600-6143.2003.00313.x | en_HK |
dc.identifier.pmid | 14974940 | - |
dc.identifier.scopus | eid_2-s2.0-1342304224 | en_HK |
dc.identifier.hkuros | 85952 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-1342304224&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 4 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 196 | en_HK |
dc.identifier.epage | 209 | en_HK |
dc.identifier.isi | WOS:000188644100008 | - |
dc.publisher.place | Denmark | en_HK |
dc.identifier.scopusauthorid | Yang, ZF=14018809600 | en_HK |
dc.identifier.scopusauthorid | Ho, DWY=7402971906 | en_HK |
dc.identifier.scopusauthorid | Chu, ACY=24343085700 | en_HK |
dc.identifier.scopusauthorid | Wang, YQ=23981317400 | en_HK |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_HK |
dc.identifier.issnl | 1600-6135 | - |