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- Publisher Website: 10.1016/0022-4804(86)90009-0
- Scopus: eid_2-s2.0-0022922509
- PMID: 3747498
- WOS: WOS:A1986E073300008
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Article: Chronic gastric ulcers are not predisposed to tumor formation when exposed to a low dose of carcinogen
Title | Chronic gastric ulcers are not predisposed to tumor formation when exposed to a low dose of carcinogen |
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Authors | |
Issue Date | 1986 |
Publisher | Elsevier Inc.. The Journal's web site is located at http://www.elsevier.com/locate/jsre |
Citation | Journal Of Surgical Research, 1986, v. 41 n. 1, p. 58-64 How to Cite? |
Abstract | The purpose of this experiment was to determine whether chronic gastric ulcers in the rat are predisposed to tumor formation when exposed to a usually noncarcinogenic dose of the carcinogen, N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG). Two groups of rats were prepared; one subjected to a standard ulcer-producing operation, the others as control. Both groups were given oral MNNG (100 mg/liter as drinking water) for 12 weeks, the carcinogen was then stopped and replaced with tap water, and the experiment terminated at 52 weeks. Results showed that a low dose of carcinogen (200 mg) did not induce tumor formation in any of the normal rats. In the presence of a chronic gastric ulcer, only intestinal metaplasia and hyperplastic glandular nodules were observed, but there were no gastric tumors. It is concluded that the presence of a chronic gastric ulcer did not increase the likelihood of gastric tumor formation in rats treated with a noncarcinogenic dose of the carcinogen MNNG. |
Persistent Identifier | http://hdl.handle.net/10722/172549 |
ISSN | 2023 Impact Factor: 1.8 2023 SCImago Journal Rankings: 0.748 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Siu, KF | en_HK |
dc.contributor.author | Wei, WI | en_HK |
dc.contributor.author | Wong, J | en_HK |
dc.date.accessioned | 2012-10-30T06:23:21Z | - |
dc.date.available | 2012-10-30T06:23:21Z | - |
dc.date.issued | 1986 | en_HK |
dc.identifier.citation | Journal Of Surgical Research, 1986, v. 41 n. 1, p. 58-64 | en_HK |
dc.identifier.issn | 0022-4804 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/172549 | - |
dc.description.abstract | The purpose of this experiment was to determine whether chronic gastric ulcers in the rat are predisposed to tumor formation when exposed to a usually noncarcinogenic dose of the carcinogen, N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG). Two groups of rats were prepared; one subjected to a standard ulcer-producing operation, the others as control. Both groups were given oral MNNG (100 mg/liter as drinking water) for 12 weeks, the carcinogen was then stopped and replaced with tap water, and the experiment terminated at 52 weeks. Results showed that a low dose of carcinogen (200 mg) did not induce tumor formation in any of the normal rats. In the presence of a chronic gastric ulcer, only intestinal metaplasia and hyperplastic glandular nodules were observed, but there were no gastric tumors. It is concluded that the presence of a chronic gastric ulcer did not increase the likelihood of gastric tumor formation in rats treated with a noncarcinogenic dose of the carcinogen MNNG. | en_HK |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc.. The Journal's web site is located at http://www.elsevier.com/locate/jsre | en_HK |
dc.relation.ispartof | Journal of Surgical Research | en_HK |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Carcinogens - Pharmacology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gastric Acid - Secretion | en_US |
dc.subject.mesh | Gastrins - Blood | en_US |
dc.subject.mesh | Liver - Drug Effects - Pathology | en_US |
dc.subject.mesh | Methylnitronitrosoguanidine - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Stomach - Drug Effects - Pathology | en_US |
dc.subject.mesh | Stomach Neoplasms - Etiology | en_US |
dc.subject.mesh | Stomach Ulcer - Complications - Pathology | en_US |
dc.title | Chronic gastric ulcers are not predisposed to tumor formation when exposed to a low dose of carcinogen | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Wei, WI: hrmswwi@hku.hk | en_HK |
dc.identifier.email | Wong, J: jwong@hkucc.hku.hk | en_HK |
dc.identifier.authority | Wei, WI=rp00323 | en_HK |
dc.identifier.authority | Wong, J=rp00322 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0022-4804(86)90009-0 | - |
dc.identifier.pmid | 3747498 | - |
dc.identifier.scopus | eid_2-s2.0-0022922509 | en_HK |
dc.identifier.volume | 41 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 58 | en_HK |
dc.identifier.epage | 64 | en_HK |
dc.identifier.isi | WOS:A1986E073300008 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Siu, KF=24380342300 | en_HK |
dc.identifier.scopusauthorid | Wei, WI=7403321552 | en_HK |
dc.identifier.scopusauthorid | Wong, J=8049324500 | en_HK |
dc.identifier.issnl | 0022-4804 | - |