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- Publisher Website: 10.1002/bjs.1800701110
- Scopus: eid_2-s2.0-0021026837
- PMID: 6315120
- WOS: WOS:A1983RU05100008
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Article: Prophylaxis of postappendicectomy sepsis by metronidazole and cefotaxime; a randomized, prospective and double blind trial
Title | Prophylaxis of postappendicectomy sepsis by metronidazole and cefotaxime; a randomized, prospective and double blind trial |
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Authors | |
Issue Date | 1983 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uk |
Citation | British Journal Of Surgery, 1983, v. 70 n. 11, p. 670-672 How to Cite? |
Abstract | A randomized, prospective and double blind trial was conducted on 308 patients. Thirty-one out of 102 patients receiving metronidazole developed wound infection compared with 13 out of 103 patients receiving cefotaxime and 14 out of 103 patients receiving metronidazole and cefotaxime. The reduction in the wound sepsis by the use of cefotaxime or a combination of metronidazole and cefotaxime was statistically significant when compared with patients who received metronidazole only. For early cases including normal, acutely inflamed and gangrenous appendices, we gave a single dose of antibiotics just before operation. For late cases with perforation and abscess formation, the antibiotics were continued for 5 days. There was no statistical difference in wound infection between patients who received cefotaxime alone and these who received a combination of metronidazole and cefotaxime. |
Persistent Identifier | http://hdl.handle.net/10722/172524 |
ISSN | 2023 Impact Factor: 8.6 2023 SCImago Journal Rankings: 2.148 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lau, WY | en_US |
dc.contributor.author | Fan, ST | en_US |
dc.contributor.author | Yiu, TF | en_US |
dc.date.accessioned | 2012-10-30T06:23:14Z | - |
dc.date.available | 2012-10-30T06:23:14Z | - |
dc.date.issued | 1983 | en_US |
dc.identifier.citation | British Journal Of Surgery, 1983, v. 70 n. 11, p. 670-672 | en_US |
dc.identifier.issn | 0007-1323 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/172524 | - |
dc.description.abstract | A randomized, prospective and double blind trial was conducted on 308 patients. Thirty-one out of 102 patients receiving metronidazole developed wound infection compared with 13 out of 103 patients receiving cefotaxime and 14 out of 103 patients receiving metronidazole and cefotaxime. The reduction in the wound sepsis by the use of cefotaxime or a combination of metronidazole and cefotaxime was statistically significant when compared with patients who received metronidazole only. For early cases including normal, acutely inflamed and gangrenous appendices, we gave a single dose of antibiotics just before operation. For late cases with perforation and abscess formation, the antibiotics were continued for 5 days. There was no statistical difference in wound infection between patients who received cefotaxime alone and these who received a combination of metronidazole and cefotaxime. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uk | en_US |
dc.relation.ispartof | British Journal of Surgery | en_US |
dc.subject.mesh | Appendectomy | en_US |
dc.subject.mesh | Bacteria, Aerobic - Isolation & Purification | en_US |
dc.subject.mesh | Bacteria, Anaerobic - Isolation & Purification | en_US |
dc.subject.mesh | Cefotaxime - Therapeutic Use | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Clinical Trials As Topic | en_US |
dc.subject.mesh | Double-Blind Method | en_US |
dc.subject.mesh | Drug Therapy, Combination | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Metronidazole - Therapeutic Use | en_US |
dc.subject.mesh | Premedication | en_US |
dc.subject.mesh | Surgical Wound Infection - Microbiology - Prevention & Control | en_US |
dc.subject.mesh | Time Factors | en_US |
dc.title | Prophylaxis of postappendicectomy sepsis by metronidazole and cefotaxime; a randomized, prospective and double blind trial | en_US |
dc.type | Article | en_US |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_US |
dc.identifier.authority | Fan, ST=rp00355 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/bjs.1800701110 | - |
dc.identifier.pmid | 6315120 | - |
dc.identifier.scopus | eid_2-s2.0-0021026837 | en_US |
dc.identifier.volume | 70 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.spage | 670 | en_US |
dc.identifier.epage | 672 | en_US |
dc.identifier.isi | WOS:A1983RU05100008 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Lau, WY=7402933199 | en_US |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_US |
dc.identifier.scopusauthorid | Yiu, TF=36887055400 | en_US |
dc.identifier.issnl | 0007-1323 | - |