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- Publisher Website: 10.3109/00365599609181303
- Scopus: eid_2-s2.0-0029953904
- PMID: 8837255
- WOS: WOS:A1996UX23100010
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Article: Transforming growth factor-β mRNA expression in CD4+ T cells from patients with primary glomerulonephritides
Title | Transforming growth factor-β mRNA expression in CD4+ T cells from patients with primary glomerulonephritides |
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Authors | |
Keywords | CD4 T cells Glomerulosclerosis mRNA Primary glomerulonephritides Transforming growth factor- |
Issue Date | 1996 |
Publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365599.asp |
Citation | Scandinavian Journal Of Urology And Nephrology, 1996, v. 30 n. 3, p. 223-226 How to Cite? |
Abstract | Immunoreactivity to transforming growth factor-β (TGF-β) was detected in glomerular cells from patients with chronic glomerulonephritis, yet it remains uncertain whether the glomerular TGF-β deposits reflect TGF-β produced by the glomerular cells alone or from additional extrarenal origin. We examined the TGF-β messenger RNA (mRNA) expression in circulating CD4+ T cells from 45 patients with different primary glomerulonephritides. By semiquantitative polymerase chain reaction, the TGF-β mRNA expression was significantly raised in histopathologic entities characterized by increased mesangial proliferation or segmental sclerosis but not in histopathologic entities with little mesangial proliferation or sclerosis. These findings suggest that, other than TGF-β produced de novo, TGF-β from systemic source can also contribute to mesangial proliferation by binding to the glomerular cells after being filtered by the glomeruli. Increased TGF-β gene expression in CD4+ T cells in these patients may potentially enhance glomerular injury. |
Persistent Identifier | http://hdl.handle.net/10722/172014 |
ISSN | 2014 Impact Factor: 1.243 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lai, KN | en_HK |
dc.contributor.author | Ho, RTH | en_HK |
dc.contributor.author | Li, PKT | en_HK |
dc.date.accessioned | 2012-10-30T06:19:41Z | - |
dc.date.available | 2012-10-30T06:19:41Z | - |
dc.date.issued | 1996 | en_HK |
dc.identifier.citation | Scandinavian Journal Of Urology And Nephrology, 1996, v. 30 n. 3, p. 223-226 | en_HK |
dc.identifier.issn | 0036-5599 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/172014 | - |
dc.description.abstract | Immunoreactivity to transforming growth factor-β (TGF-β) was detected in glomerular cells from patients with chronic glomerulonephritis, yet it remains uncertain whether the glomerular TGF-β deposits reflect TGF-β produced by the glomerular cells alone or from additional extrarenal origin. We examined the TGF-β messenger RNA (mRNA) expression in circulating CD4+ T cells from 45 patients with different primary glomerulonephritides. By semiquantitative polymerase chain reaction, the TGF-β mRNA expression was significantly raised in histopathologic entities characterized by increased mesangial proliferation or segmental sclerosis but not in histopathologic entities with little mesangial proliferation or sclerosis. These findings suggest that, other than TGF-β produced de novo, TGF-β from systemic source can also contribute to mesangial proliferation by binding to the glomerular cells after being filtered by the glomeruli. Increased TGF-β gene expression in CD4+ T cells in these patients may potentially enhance glomerular injury. | en_HK |
dc.language | eng | en_US |
dc.publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365599.asp | en_HK |
dc.relation.ispartof | Scandinavian Journal of Urology and Nephrology | en_HK |
dc.subject | CD4 T cells | en_HK |
dc.subject | Glomerulosclerosis | en_HK |
dc.subject | mRNA | en_HK |
dc.subject | Primary glomerulonephritides | en_HK |
dc.subject | Transforming growth factor- | en_HK |
dc.subject.mesh | Cd4-Positive T-Lymphocytes - Chemistry | en_US |
dc.subject.mesh | Glomerulonephritis - Immunology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Molecular Sequence Data | en_US |
dc.subject.mesh | Polymerase Chain Reaction | en_US |
dc.subject.mesh | Rna, Messenger - Analysis | en_US |
dc.subject.mesh | Transforming Growth Factor Beta - Genetics | en_US |
dc.title | Transforming growth factor-β mRNA expression in CD4+ T cells from patients with primary glomerulonephritides | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lai, KN: knlai@hku.hk | en_HK |
dc.identifier.email | Ho, RTH: tinho@hku.hk | en_HK |
dc.identifier.authority | Lai, KN=rp00324 | en_HK |
dc.identifier.authority | Ho, RTH=rp00497 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.3109/00365599609181303 | - |
dc.identifier.pmid | 8837255 | - |
dc.identifier.scopus | eid_2-s2.0-0029953904 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0029953904&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 30 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 223 | en_HK |
dc.identifier.epage | 226 | en_HK |
dc.identifier.isi | WOS:A1996UX23100010 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Lai, KN=7402135706 | en_HK |
dc.identifier.scopusauthorid | Ho, RTH=8620896500 | en_HK |
dc.identifier.scopusauthorid | Li, PKT=25928016800 | en_HK |
dc.identifier.issnl | 0036-5599 | - |