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- Publisher Website: 10.4049/jimmunol.0903873
- Scopus: eid_2-s2.0-77954497180
- PMID: 20357255
- WOS: WOS:000277093000011
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Article: Cutting edge: Granulocyte-macrophage colony-stimulating factor is the major CD8 + T cell-derived licensing factor for dendritic cell activation
Title | Cutting edge: Granulocyte-macrophage colony-stimulating factor is the major CD8 + T cell-derived licensing factor for dendritic cell activation |
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Authors | |
Issue Date | 2010 |
Publisher | American Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org |
Citation | Journal Of Immunology, 2010, v. 184 n. 9, p. 4625-4629 How to Cite? |
Abstract | During priming, CD8 + T lymphocytes can induce robust maturation of dendritic cells (DCs) in a CD40-independent manner by secreting licensing factor(s). In this study, we isolate this so-far elusive licensing factor and identify it, surprisingly, as GM-CSF. This provides a new face for an old factor with a well-known supporting role in DC development and recruitment. Signaling through the GM-CSFR in ex vivo-purified DCs upregulated the expression of costimulatory molecules more efficiently than did any tested TLR agonist and provided a positive feedback loop in the stimulation of CD8 + T cell proliferation. Combined with a variety of microbial stimuli, GM-CSF supports the formation of potent "effector" DCs capable of secreting a variety of proinflammatory cytokines that guide the differentiation of T cells during the immune response. Copyright © 2010 by The American Association of Immunologists, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/171781 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 1.558 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, L | en_US |
dc.contributor.author | Isa, SABM | en_US |
dc.contributor.author | Shuai, W | en_US |
dc.contributor.author | Piang, CB | en_US |
dc.contributor.author | Nih, FW | en_US |
dc.contributor.author | Kotaka, M | en_US |
dc.contributor.author | Ruedl, C | en_US |
dc.date.accessioned | 2012-10-30T06:17:03Z | - |
dc.date.available | 2012-10-30T06:17:03Z | - |
dc.date.issued | 2010 | en_US |
dc.identifier.citation | Journal Of Immunology, 2010, v. 184 n. 9, p. 4625-4629 | en_US |
dc.identifier.issn | 0022-1767 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171781 | - |
dc.description.abstract | During priming, CD8 + T lymphocytes can induce robust maturation of dendritic cells (DCs) in a CD40-independent manner by secreting licensing factor(s). In this study, we isolate this so-far elusive licensing factor and identify it, surprisingly, as GM-CSF. This provides a new face for an old factor with a well-known supporting role in DC development and recruitment. Signaling through the GM-CSFR in ex vivo-purified DCs upregulated the expression of costimulatory molecules more efficiently than did any tested TLR agonist and provided a positive feedback loop in the stimulation of CD8 + T cell proliferation. Combined with a variety of microbial stimuli, GM-CSF supports the formation of potent "effector" DCs capable of secreting a variety of proinflammatory cytokines that guide the differentiation of T cells during the immune response. Copyright © 2010 by The American Association of Immunologists, Inc. | en_US |
dc.language | eng | en_US |
dc.publisher | American Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org | en_US |
dc.relation.ispartof | Journal of Immunology | en_US |
dc.title | Cutting edge: Granulocyte-macrophage colony-stimulating factor is the major CD8 + T cell-derived licensing factor for dendritic cell activation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Kotaka, M:masayo@hku.hk | en_US |
dc.identifier.authority | Kotaka, M=rp00293 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.4049/jimmunol.0903873 | en_US |
dc.identifier.pmid | 20357255 | - |
dc.identifier.scopus | eid_2-s2.0-77954497180 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77954497180&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 184 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.spage | 4625 | en_US |
dc.identifier.epage | 4629 | en_US |
dc.identifier.isi | WOS:000277093000011 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Min, L=36189351800 | en_US |
dc.identifier.scopusauthorid | Isa, SABM=36452913600 | en_US |
dc.identifier.scopusauthorid | Shuai, W=23010818500 | en_US |
dc.identifier.scopusauthorid | Piang, CB=36167177400 | en_US |
dc.identifier.scopusauthorid | Nih, FW=36167079200 | en_US |
dc.identifier.scopusauthorid | Kotaka, M=6604073578 | en_US |
dc.identifier.scopusauthorid | Ruedl, C=6603812935 | en_US |
dc.identifier.issnl | 0022-1767 | - |