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Article: Nitric oxide modulation of voltage-gated calcium current by S-nitrosylation and cGMP pathway in cultured rat hippocampal neurons

TitleNitric oxide modulation of voltage-gated calcium current by S-nitrosylation and cGMP pathway in cultured rat hippocampal neurons
Authors
Jian, KChen, MCao, XZhu, XHFung, MLGao, TM
KeywordscGMP pathway
Hippocampus
Nitric oxide
S-Nitrosylation
Voltage-gated calcium currents
Issue Date2007
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2007, v. 359 n. 3, p. 481-485 How to Cite?
DOI: http://dx.doi.org/10.1016/j.bbrc.2007.05.113
AbstractNitric oxide (NO) plays an important role in many physiological and pathophysiological processes in the brain. In this study, we examined the mechanistic effects of an NO donor, diethylenetriamine/nitric oxide adduct (DETA/NO) on the voltage-gated calcium currents in cultured rat hippocampal neurons. DETA/NO stimulated the calcium currents and slightly increased the channel sensitivity to depolarizing voltages. The effect of DETA/NO on the calcium current was blocked by either depleting the NO in DETA/NO or by pretreating the neurons with NEM, a thiol-specific alkylating agent, suggesting an involvement of S-nitrosylation in the current response to NO. In addition, activation of the cGMP pathway by 8-Br-cGMP inhibited the calcium current in the neurons. Also, inhibition of guanylyl cyclase by 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one (ODQ) increased the current response to DETA/NO. Taken together, our results demonstrate that both S-nitrosylation and cGMP pathway are involved in the NO modulation of the hippocampal calcium current. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/171757
ISSN
0006-291X
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.770
ISI Accession Number ID
WOS:000247582500014
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorJian, Ken_US
dc.contributor.authorChen, Men_US
dc.contributor.authorCao, Xen_US
dc.contributor.authorZhu, XHen_US
dc.contributor.authorFung, MLen_US
dc.contributor.authorGao, TMen_US
dc.date.accessioned2012-10-30T06:16:49Z-
dc.date.available2012-10-30T06:16:49Z-
dc.date.issued2007en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 2007, v. 359 n. 3, p. 481-485en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/171757-
dc.description.abstractNitric oxide (NO) plays an important role in many physiological and pathophysiological processes in the brain. In this study, we examined the mechanistic effects of an NO donor, diethylenetriamine/nitric oxide adduct (DETA/NO) on the voltage-gated calcium currents in cultured rat hippocampal neurons. DETA/NO stimulated the calcium currents and slightly increased the channel sensitivity to depolarizing voltages. The effect of DETA/NO on the calcium current was blocked by either depleting the NO in DETA/NO or by pretreating the neurons with NEM, a thiol-specific alkylating agent, suggesting an involvement of S-nitrosylation in the current response to NO. In addition, activation of the cGMP pathway by 8-Br-cGMP inhibited the calcium current in the neurons. Also, inhibition of guanylyl cyclase by 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one (ODQ) increased the current response to DETA/NO. Taken together, our results demonstrate that both S-nitrosylation and cGMP pathway are involved in the NO modulation of the hippocampal calcium current. © 2007 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subjectcGMP pathway-
dc.subjectHippocampus-
dc.subjectNitric oxide-
dc.subjectS-Nitrosylation-
dc.subjectVoltage-gated calcium currents-
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium Channels - Metabolismen_US
dc.subject.meshCyclic Gmp - Metabolismen_US
dc.subject.meshHippocampus - Drug Effects - Metabolismen_US
dc.subject.meshIon Channel Gatingen_US
dc.subject.meshNeurons - Drug Effects - Metabolismen_US
dc.subject.meshNitric Oxide - Metabolismen_US
dc.subject.meshNitrogen - Metabolismen_US
dc.subject.meshPolyamines - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshTissue Culture Techniquesen_US
dc.titleNitric oxide modulation of voltage-gated calcium current by S-nitrosylation and cGMP pathway in cultured rat hippocampal neuronsen_US
dc.typeArticleen_US
dc.identifier.emailFung, ML:fungml@hkucc.hku.hken_US
dc.identifier.authorityFung, ML=rp00433en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bbrc.2007.05.113en_US
dc.identifier.pmid17544367-
dc.identifier.scopuseid_2-s2.0-34250172430en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250172430&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume359en_US
dc.identifier.issue3en_US
dc.identifier.spage481en_US
dc.identifier.epage485en_US
dc.identifier.isiWOS:000247582500014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJian, K=36929518800en_US
dc.identifier.scopusauthoridChen, M=35285618500en_US
dc.identifier.scopusauthoridCao, X=36985373700en_US
dc.identifier.scopusauthoridZhu, XH=7406186945en_US
dc.identifier.scopusauthoridFung, ML=7101955092en_US
dc.identifier.scopusauthoridGao, TM=7101845480en_US
dc.identifier.issnl0006-291X-

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