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Article: Control of the mode of excitation-contraction coupling by Ca2+ stores in bovine trachealis muscle
Title | Control of the mode of excitation-contraction coupling by Ca2+ stores in bovine trachealis muscle |
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Authors | |
Keywords | Calcium influx Calcium release Potassium channels Tracheal smooth muscle |
Issue Date | 2000 |
Publisher | American Physiological Society. The Journal's web site is located at http://intl-ajplung.physiology.org/ |
Citation | American Journal Of Physiology - Lung Cellular And Molecular Physiology, 2000, v. 279 n. 4, p. L722-L732 How to Cite? |
Abstract | Full muscarinic stimulation in bovine tracheal smooth muscle caused a sustained contraction and increase in intracellular Ca2+ concentration ([Ca2+](i)) that was largely resistant to inhibition by nifedipine. Depletion of internal Ca2+ stores with cyclopiazonic acid resulted in an increased efficacy of nifedipine to inhibit this contraction and the associated increase in [Ca2+](i). Thus internal Ca2+ store depletion promoted electromechanical coupling between full muscarinic stimulation and muscle contraction to the detriment of pharmacomechanical coupling. A similar change in coupling mode was induced by ryanodine even when it did not significantly modify the initial transient increase in [Ca2+](i) induced by this stimulation, indicating that depletion of internal stores was not necessary to induce the change in excitation-contraction coupling mode. Blockade of the Ca2+-activated K+ channel by tetraethylammonium, charybdotoxin, and iberiotoxin all induced the change in excitation-contraction coupling mode. These results suggest that in this preparation, Ca2+ released from the ryanodine-sensitive Ca2+ store, by activating Ca2+-activated K+ channels, plays a central role in determining the expression of the pharmacomechanical coupling mode between muscarinic excitation and the Ca2+ influx necessary for the maintenance of tone. |
Persistent Identifier | http://hdl.handle.net/10722/171674 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 1.339 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tao, L | en_US |
dc.contributor.author | Huang, Y | en_US |
dc.contributor.author | Bourreau, JP | en_US |
dc.date.accessioned | 2012-10-30T06:16:17Z | - |
dc.date.available | 2012-10-30T06:16:17Z | - |
dc.date.issued | 2000 | en_US |
dc.identifier.citation | American Journal Of Physiology - Lung Cellular And Molecular Physiology, 2000, v. 279 n. 4, p. L722-L732 | en_US |
dc.identifier.issn | 1040-0605 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171674 | - |
dc.description.abstract | Full muscarinic stimulation in bovine tracheal smooth muscle caused a sustained contraction and increase in intracellular Ca2+ concentration ([Ca2+](i)) that was largely resistant to inhibition by nifedipine. Depletion of internal Ca2+ stores with cyclopiazonic acid resulted in an increased efficacy of nifedipine to inhibit this contraction and the associated increase in [Ca2+](i). Thus internal Ca2+ store depletion promoted electromechanical coupling between full muscarinic stimulation and muscle contraction to the detriment of pharmacomechanical coupling. A similar change in coupling mode was induced by ryanodine even when it did not significantly modify the initial transient increase in [Ca2+](i) induced by this stimulation, indicating that depletion of internal stores was not necessary to induce the change in excitation-contraction coupling mode. Blockade of the Ca2+-activated K+ channel by tetraethylammonium, charybdotoxin, and iberiotoxin all induced the change in excitation-contraction coupling mode. These results suggest that in this preparation, Ca2+ released from the ryanodine-sensitive Ca2+ store, by activating Ca2+-activated K+ channels, plays a central role in determining the expression of the pharmacomechanical coupling mode between muscarinic excitation and the Ca2+ influx necessary for the maintenance of tone. | en_US |
dc.language | eng | en_US |
dc.publisher | American Physiological Society. The Journal's web site is located at http://intl-ajplung.physiology.org/ | en_US |
dc.relation.ispartof | American Journal of Physiology - Lung Cellular and Molecular Physiology | en_US |
dc.subject | Calcium influx | - |
dc.subject | Calcium release | - |
dc.subject | Potassium channels | - |
dc.subject | Tracheal smooth muscle | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bethanechol - Pharmacology | en_US |
dc.subject.mesh | Calcium - Metabolism | en_US |
dc.subject.mesh | Calcium Channel Blockers - Pharmacology | en_US |
dc.subject.mesh | Cattle | en_US |
dc.subject.mesh | Charybdotoxin - Pharmacology | en_US |
dc.subject.mesh | Kinetics | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects - Physiology | en_US |
dc.subject.mesh | Muscle, Smooth - Drug Effects - Physiology | en_US |
dc.subject.mesh | Nifedipine - Pharmacology | en_US |
dc.subject.mesh | Peptides - Pharmacology | en_US |
dc.subject.mesh | Potassium Channels - Drug Effects - Physiology | en_US |
dc.subject.mesh | Ryanodine - Pharmacology | en_US |
dc.subject.mesh | Tetraethylammonium - Pharmacology | en_US |
dc.subject.mesh | Trachea - Drug Effects - Physiology | en_US |
dc.title | Control of the mode of excitation-contraction coupling by Ca2+ stores in bovine trachealis muscle | en_US |
dc.type | Article | en_US |
dc.identifier.email | Bourreau, JP:bourreau@hkucc.hku.hk | en_US |
dc.identifier.authority | Bourreau, JP=rp00389 | en_US |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.pmid | 11000133 | - |
dc.identifier.scopus | eid_2-s2.0-0033711376 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0033711376&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 279 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | L722 | en_US |
dc.identifier.epage | L732 | en_US |
dc.identifier.isi | WOS:000089467300015 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Tao, L=14067858700 | en_US |
dc.identifier.scopusauthorid | Huang, Y=7501573013 | en_US |
dc.identifier.scopusauthorid | Bourreau, JP=7003927886 | en_US |
dc.customcontrol.immutable | csl 160524 | - |
dc.identifier.issnl | 1040-0605 | - |