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Article: Calcium Signaling by Cyclic ADP-Ribose and NAADP: A Decade of Exploration
Title | Calcium Signaling by Cyclic ADP-Ribose and NAADP: A Decade of Exploration |
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Authors | |
Keywords | ADP-ribosyl cyclase Ca+2 signaling CD38 Cyclic ADP-ribose (cADPR) NAADP |
Issue Date | 1998 |
Citation | Cell Biochemistry And Biophysics, 1998, v. 28 n. 1, p. 1-17 How to Cite? |
Abstract | Ca2+ mobilization as a signaling mechanism has been placed on center stage with the discovery of the first Ca2+ messenger, inositol trisphosphate (IP3). This article focuses on two new Ca2+ release activators, which mobilize internal Ca2+ stores via mechanisms totally independent of IP3. They are cyclic ADP-ribose (cADPR) and nicotinic acid dinucleotide phosphate (NAADP), metabolites derived respectively from NAD and NADP. Major advances in the past decade in the understanding of these two novel signaling mechanisms are chronologically summarized. |
Persistent Identifier | http://hdl.handle.net/10722/171648 |
ISSN | 2023 Impact Factor: 1.8 2023 SCImago Journal Rankings: 0.596 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, HC | en_US |
dc.date.accessioned | 2012-10-30T06:16:08Z | - |
dc.date.available | 2012-10-30T06:16:08Z | - |
dc.date.issued | 1998 | en_US |
dc.identifier.citation | Cell Biochemistry And Biophysics, 1998, v. 28 n. 1, p. 1-17 | en_US |
dc.identifier.issn | 1085-9195 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171648 | - |
dc.description.abstract | Ca2+ mobilization as a signaling mechanism has been placed on center stage with the discovery of the first Ca2+ messenger, inositol trisphosphate (IP3). This article focuses on two new Ca2+ release activators, which mobilize internal Ca2+ stores via mechanisms totally independent of IP3. They are cyclic ADP-ribose (cADPR) and nicotinic acid dinucleotide phosphate (NAADP), metabolites derived respectively from NAD and NADP. Major advances in the past decade in the understanding of these two novel signaling mechanisms are chronologically summarized. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Cell Biochemistry and Biophysics | en_US |
dc.subject | ADP-ribosyl cyclase | - |
dc.subject | Ca+2 signaling | - |
dc.subject | CD38 | - |
dc.subject | Cyclic ADP-ribose (cADPR) | - |
dc.subject | NAADP | - |
dc.subject.mesh | Adenosine Diphosphate Ribose - Analogs & Derivatives - Chemistry - Physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Calcium - Physiology | en_US |
dc.subject.mesh | Cyclic Adp-Ribose | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Models, Molecular | en_US |
dc.subject.mesh | Nad - Analogs & Derivatives - Chemistry - Physiology | en_US |
dc.subject.mesh | Signal Transduction | en_US |
dc.title | Calcium Signaling by Cyclic ADP-Ribose and NAADP: A Decade of Exploration | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, HC:leehc@hku.hk | en_US |
dc.identifier.authority | Lee, HC=rp00545 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 9386889 | - |
dc.identifier.scopus | eid_2-s2.0-0031972642 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0031972642&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 17 | en_US |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lee, HC=26642959100 | en_US |
dc.identifier.issnl | 1085-9195 | - |