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Article: Differential effects of guanosine 5'-O-(3-thiotriphosphate) (GTPγS) on the 2-[125I]iodomelatonin binding sites in the chicken bursa of Fabricius and spleen

TitleDifferential effects of guanosine 5'-O-(3-thiotriphosphate) (GTPγS) on the 2-[125I]iodomelatonin binding sites in the chicken bursa of Fabricius and spleen
Authors
Poon, AMSPang, SF
KeywordsDown-regulation
G protein melatonin receptor subtypes
Guanine nucleotide
Immune system
Pineal gland
Issue Date1994
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1994, v. 173 n. 1-2, p. 167-171 How to Cite?
DOI: http://dx.doi.org/10.1016/0304-3940(94)90175-9
AbstractEffects of 10 and 50 μmol/l guanosine 5'-0-(3-thiotriphosphate) (GTPγS) on 2-[125I]iodomelatonin binding in the chicken bursa of Fabricius and spleen were tested. In the chicken bursa of Fabricius, GTPγS increased the K(d) of 2-[125]iodomelatonin binding sites without affecting the B(max) value. In contrast, GTPγS caused both an increase in K(d) and a reduction in B(max) of 2-[125I]iodomelatonin binding sites in the chicken spleen. Our results suggest the existence of subtypes of melatonin receptors with different receptor-G protein-effector complexes in the avian primary and secondary lymphoid systems.
Persistent Identifierhttp://hdl.handle.net/10722/171609
ISSN
0304-3940
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.745
ISI Accession Number ID
WOS:A1994PF44800040

 

DC FieldValueLanguage
dc.contributor.authorPoon, AMSen_US
dc.contributor.authorPang, SFen_US
dc.date.accessioned2012-10-30T06:15:57Z-
dc.date.available2012-10-30T06:15:57Z-
dc.date.issued1994en_US
dc.identifier.citationNeuroscience Letters, 1994, v. 173 n. 1-2, p. 167-171en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/171609-
dc.description.abstractEffects of 10 and 50 μmol/l guanosine 5'-0-(3-thiotriphosphate) (GTPγS) on 2-[125I]iodomelatonin binding in the chicken bursa of Fabricius and spleen were tested. In the chicken bursa of Fabricius, GTPγS increased the K(d) of 2-[125]iodomelatonin binding sites without affecting the B(max) value. In contrast, GTPγS caused both an increase in K(d) and a reduction in B(max) of 2-[125I]iodomelatonin binding sites in the chicken spleen. Our results suggest the existence of subtypes of melatonin receptors with different receptor-G protein-effector complexes in the avian primary and secondary lymphoid systems.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.-
dc.subjectDown-regulation-
dc.subjectG protein melatonin receptor subtypes-
dc.subjectGuanine nucleotide-
dc.subjectImmune system-
dc.subjectPineal gland-
dc.subject.meshAnimalsen_US
dc.subject.meshBursa Of Fabricius - Drug Effects - Metabolismen_US
dc.subject.meshChickensen_US
dc.subject.meshDown-Regulation - Drug Effectsen_US
dc.subject.meshGuanosine 5'-O-(3-Thiotriphosphate) - Pharmacologyen_US
dc.subject.meshGuanosine Triphosphate - Pharmacologyen_US
dc.subject.meshIodine Radioisotopes - Diagnostic Useen_US
dc.subject.meshKineticsen_US
dc.subject.meshMelatonin - Metabolismen_US
dc.subject.meshMembranes - Drug Effects - Metabolismen_US
dc.subject.meshReceptors, Cell Surface - Drug Effects - Metabolismen_US
dc.subject.meshReceptors, Melatoninen_US
dc.subject.meshSpleen - Drug Effects - Metabolismen_US
dc.titleDifferential effects of guanosine 5'-O-(3-thiotriphosphate) (GTPγS) on the 2-[125I]iodomelatonin binding sites in the chicken bursa of Fabricius and spleenen_US
dc.typeArticleen_US
dc.identifier.emailPoon, AMS:amspoon@hkucc.hku.hken_US
dc.identifier.emailPang, SF: hrmypsf@hkucc.hku.hk-
dc.identifier.authorityPoon, AMS=rp00354en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0304-3940(94)90175-9en_US
dc.identifier.pmid7936407-
dc.identifier.scopuseid_2-s2.0-0028304211en_US
dc.identifier.hkuros2698-
dc.identifier.volume173en_US
dc.identifier.issue1-2en_US
dc.identifier.spage167en_US
dc.identifier.epage171en_US
dc.identifier.isiWOS:A1994PF44800040-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridPoon, AMS=7103068868en_US
dc.identifier.scopusauthoridPang, SF=7402528719en_US
dc.identifier.issnl0304-3940-

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