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- Publisher Website: 10.1016/0898-6568(94)90042-6
- Scopus: eid_2-s2.0-0028080275
- PMID: 7857763
- WOS: WOS:A1994PQ56500002
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Article: Cyclic ADP-ribose: A new member of a super family of signalling cyclic nucleotides
| Title | Cyclic ADP-ribose: A new member of a super family of signalling cyclic nucleotides |
|---|---|
| Authors | |
| Keywords | 4 5-trisphosphate ADP-ribosyl cyclase Ca2+ mobilization CD38 cGMP Cyclic ADP-ribose Da2+-induced Ca2+ release inositol 1 ryanodine receptor |
| Issue Date | 1994 |
| Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cellsig |
| Citation | Cellular Signalling, 1994, v. 6 n. 6, p. 591-600 How to Cite? |
| Abstract | Cyclic nucleotides are second messengers exerting their cellular effects mainly through protein phosphorylation, A new member of this family, cyclic ADP-ribose, is involved, instead, in mediating mobilization of Ca2+ from internal stores. The structure of this nucleotide has now been determined by X-ray crystallography and accumulating evidence indicates it may be an endogenous modulator of the Ca2+ induced Ca+2 release mechanism. This article summarizes the current knowledge of the structure, the mechanism of action and the metabolic enzymes of this novel nucleotide. With this new addition, the signalling functions of the cyclic nucleotide family are now extended from protein phosphorylation to Ca2+ signalling. |
| Persistent Identifier | http://hdl.handle.net/10722/171602 |
| ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 1.317 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee, HC | en_US |
| dc.date.accessioned | 2012-10-30T06:15:55Z | - |
| dc.date.available | 2012-10-30T06:15:55Z | - |
| dc.date.issued | 1994 | en_US |
| dc.identifier.citation | Cellular Signalling, 1994, v. 6 n. 6, p. 591-600 | en_US |
| dc.identifier.issn | 0898-6568 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/171602 | - |
| dc.description.abstract | Cyclic nucleotides are second messengers exerting their cellular effects mainly through protein phosphorylation, A new member of this family, cyclic ADP-ribose, is involved, instead, in mediating mobilization of Ca2+ from internal stores. The structure of this nucleotide has now been determined by X-ray crystallography and accumulating evidence indicates it may be an endogenous modulator of the Ca2+ induced Ca+2 release mechanism. This article summarizes the current knowledge of the structure, the mechanism of action and the metabolic enzymes of this novel nucleotide. With this new addition, the signalling functions of the cyclic nucleotide family are now extended from protein phosphorylation to Ca2+ signalling. | en_US |
| dc.language | eng | en_US |
| dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cellsig | en_US |
| dc.relation.ispartof | Cellular Signalling | en_US |
| dc.subject | 4 | - |
| dc.subject | 5-trisphosphate | - |
| dc.subject | ADP-ribosyl cyclase | - |
| dc.subject | Ca2+ mobilization | - |
| dc.subject | CD38 | - |
| dc.subject | cGMP | - |
| dc.subject | Cyclic ADP-ribose | - |
| dc.subject | Da2+-induced Ca2+ release | - |
| dc.subject | inositol 1 | - |
| dc.subject | ryanodine receptor | - |
| dc.subject.mesh | Adenosine Diphosphate Ribose - Analogs & Derivatives - Chemistry - Physiology | en_US |
| dc.subject.mesh | Animals | en_US |
| dc.subject.mesh | Calcium - Metabolism | en_US |
| dc.subject.mesh | Cyclic Adp-Ribose | en_US |
| dc.subject.mesh | Humans | en_US |
| dc.subject.mesh | Nucleotides, Cyclic - Physiology | en_US |
| dc.subject.mesh | Phosphorylation | en_US |
| dc.subject.mesh | Second Messenger Systems | en_US |
| dc.subject.mesh | Signal Transduction - Physiology | en_US |
| dc.subject.mesh | Structure-Activity Relationship | en_US |
| dc.title | Cyclic ADP-ribose: A new member of a super family of signalling cyclic nucleotides | en_US |
| dc.type | Article | en_US |
| dc.identifier.email | Lee, HC:leehc@hku.hk | en_US |
| dc.identifier.authority | Lee, HC=rp00545 | en_US |
| dc.description.nature | link_to_subscribed_fulltext | en_US |
| dc.identifier.doi | 10.1016/0898-6568(94)90042-6 | en_US |
| dc.identifier.pmid | 7857763 | - |
| dc.identifier.scopus | eid_2-s2.0-0028080275 | en_US |
| dc.identifier.volume | 6 | en_US |
| dc.identifier.issue | 6 | en_US |
| dc.identifier.spage | 591 | en_US |
| dc.identifier.epage | 600 | en_US |
| dc.identifier.isi | WOS:A1994PQ56500002 | - |
| dc.publisher.place | United States | en_US |
| dc.identifier.scopusauthorid | Lee, HC=26642959100 | en_US |
| dc.identifier.issnl | 0898-6568 | - |