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Article: Changes in prejunctional potency of B-HT 933 during aging in the rat vas deferens

TitleChanges in prejunctional potency of B-HT 933 during aging in the rat vas deferens
Authors
Pagenkopf, CWBourreau, JPChallice, CE
Keywordsaging
B‐HT 933
prejunctional receptors
rat vas deferens.
α 2‐adrenoceptors
Issue Date1990
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1990, v. 17 n. 8, p. 557-565 How to Cite?
DOI: http://dx.doi.org/10.1111/j.1440-1681.1990.tb01356.x
Abstract1. Age-related changes in prejunctional α2-adrenoceptors were examined in the rat vas deferens using pharmacological techniques. 2. B-HT 933 (1x10-8-1x10-6 mol/L) caused a concentration-dependent inhibition of isometric contractions (tetrodotoxin-sensitive) induced by stimulation with single field-stimulus pulses, in both the epididymal and prostatic regions of rat vas deferens. The concentration-response curve to B-HT 933 was shifted to the right with age in the prostatic regions of the vas deferens. 3. In high concentrations (10-6-3x10-4 mol/L), B-HT 933 caused concentration-dependent enhancement of the contractile response to stimulation and evoked spontaneous contractile activity. No significant difference in this postjunctional activity occurred with age in either the prostatic or epididymal regions of the vas deferens. 4. Schild analysis revealed no significant differences in pA2 values for the antagonisms of the prejunctional inhibitory effect of B-HT 933 by rauwolscine in either the prostatic or epididymal regions of vas deferens between young and old rats. 5. These results could be interpreted as a decrease in α2-adrenoceptor number with age. The more marked decrease in the prejunctional inhibitory potency of B-HT 933 in prostatic regions of vas deferens with aging may be due to a smaller receptor reserve in this region of the vas deferens.
Persistent Identifierhttp://hdl.handle.net/10722/171542
ISSN
0305-1870
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 0.610
ISI Accession Number ID
WOS:A1990DX99300003

 

DC FieldValueLanguage
dc.contributor.authorPagenkopf, CWen_US
dc.contributor.authorBourreau, JPen_US
dc.contributor.authorChallice, CEen_US
dc.date.accessioned2012-10-30T06:15:36Z-
dc.date.available2012-10-30T06:15:36Z-
dc.date.issued1990en_US
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1990, v. 17 n. 8, p. 557-565en_US
dc.identifier.issn0305-1870en_US
dc.identifier.urihttp://hdl.handle.net/10722/171542-
dc.description.abstract1. Age-related changes in prejunctional α2-adrenoceptors were examined in the rat vas deferens using pharmacological techniques. 2. B-HT 933 (1x10-8-1x10-6 mol/L) caused a concentration-dependent inhibition of isometric contractions (tetrodotoxin-sensitive) induced by stimulation with single field-stimulus pulses, in both the epididymal and prostatic regions of rat vas deferens. The concentration-response curve to B-HT 933 was shifted to the right with age in the prostatic regions of the vas deferens. 3. In high concentrations (10-6-3x10-4 mol/L), B-HT 933 caused concentration-dependent enhancement of the contractile response to stimulation and evoked spontaneous contractile activity. No significant difference in this postjunctional activity occurred with age in either the prostatic or epididymal regions of the vas deferens. 4. Schild analysis revealed no significant differences in pA2 values for the antagonisms of the prejunctional inhibitory effect of B-HT 933 by rauwolscine in either the prostatic or epididymal regions of vas deferens between young and old rats. 5. These results could be interpreted as a decrease in α2-adrenoceptor number with age. The more marked decrease in the prejunctional inhibitory potency of B-HT 933 in prostatic regions of vas deferens with aging may be due to a smaller receptor reserve in this region of the vas deferens.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.subjectaging-
dc.subjectB‐HT 933-
dc.subjectprejunctional receptors-
dc.subjectrat vas deferens.-
dc.subjectα 2‐adrenoceptors-
dc.subject.meshAging - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAzepines - Administration & Dosage - Antagonists & Inhibitors - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Physiologyen_US
dc.subject.meshVas Deferens - Drug Effects - Physiologyen_US
dc.subject.meshYohimbine - Pharmacologyen_US
dc.titleChanges in prejunctional potency of B-HT 933 during aging in the rat vas deferensen_US
dc.typeArticleen_US
dc.identifier.emailBourreau, JP:bourreau@hkucc.hku.hken_US
dc.identifier.authorityBourreau, JP=rp00389en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1681.1990.tb01356.x-
dc.identifier.pmid2170068-
dc.identifier.scopuseid_2-s2.0-0025148295en_US
dc.identifier.volume17en_US
dc.identifier.issue8en_US
dc.identifier.spage557en_US
dc.identifier.epage565en_US
dc.identifier.isiWOS:A1990DX99300003-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridPagenkopf, CW=6508375954en_US
dc.identifier.scopusauthoridBourreau, JP=7003927886en_US
dc.identifier.scopusauthoridChallice, CE=7004068919en_US
dc.identifier.issnl0305-1870-

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