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Article: Effects of reserpine treatment on arrhythmogenesis during ischaemia and reperfusion in the isolated rat heart

TitleEffects of reserpine treatment on arrhythmogenesis during ischaemia and reperfusion in the isolated rat heart
Authors
Zhan, CYTang, FLee, AYSWong, TM
Keywordscatecholamines
enkephalins
ischaemia
isolated rat heart
noradrenaline
reperfusion
reserpine
Issue Date1989
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1989, v. 16 n. 7, p. 591-596 How to Cite?
DOI: http://dx.doi.org/10.1111/j.1440-1681.1989.tb01609.x
Abstract1. The effects of reserpine treatment on the myocardial contents of catecholamines and enkephalins and the incidence of ventricular arrhythmias during ischaemia and reperfusion in the isolated rat heart were studied. 2. Reserpine treatment almost completely depleted the heart of noradrenaline (NA). It also significantly depleted the heart of adrenaline and dopamines. It did not, however, alter the myocardial contents of enkephalins. 3. Reserpine-treatment attenuated significantly, but did not abolish, cardiac arrhythmias induced by ischaemia and reperfusion in the isolated heart preparation. 4. The results of the present study indicate that myocardial catecholamines especially NA are a contributing factor to arrhythmogenesis during ischaemia and reperfusion.
Persistent Identifierhttp://hdl.handle.net/10722/171533
ISSN
0305-1870
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 0.610
ISI Accession Number ID
WOS:A1989AP58000005

 

DC FieldValueLanguage
dc.contributor.authorZhan, CYen_US
dc.contributor.authorTang, Fen_US
dc.contributor.authorLee, AYSen_US
dc.contributor.authorWong, TMen_US
dc.date.accessioned2012-10-30T06:15:34Z-
dc.date.available2012-10-30T06:15:34Z-
dc.date.issued1989en_US
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1989, v. 16 n. 7, p. 591-596en_US
dc.identifier.issn0305-1870en_US
dc.identifier.urihttp://hdl.handle.net/10722/171533-
dc.description.abstract1. The effects of reserpine treatment on the myocardial contents of catecholamines and enkephalins and the incidence of ventricular arrhythmias during ischaemia and reperfusion in the isolated rat heart were studied. 2. Reserpine treatment almost completely depleted the heart of noradrenaline (NA). It also significantly depleted the heart of adrenaline and dopamines. It did not, however, alter the myocardial contents of enkephalins. 3. Reserpine-treatment attenuated significantly, but did not abolish, cardiac arrhythmias induced by ischaemia and reperfusion in the isolated heart preparation. 4. The results of the present study indicate that myocardial catecholamines especially NA are a contributing factor to arrhythmogenesis during ischaemia and reperfusion.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.subjectcatecholamines-
dc.subjectenkephalins-
dc.subjectischaemia-
dc.subjectisolated rat heart-
dc.subjectnoradrenaline-
dc.subjectreperfusion-
dc.subjectreserpine-
dc.subject.meshAnimalsen_US
dc.subject.meshArrhythmias, Cardiac - Etiology - Prevention & Controlen_US
dc.subject.meshCatecholamines - Physiologyen_US
dc.subject.meshChromatography, High Pressure Liquiden_US
dc.subject.meshCoronary Disease - Complications - Physiopathologyen_US
dc.subject.meshEnkephalins - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMyocardial Reperfusion Injury - Complications - Physiopathologyen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshReserpine - Pharmacologyen_US
dc.titleEffects of reserpine treatment on arrhythmogenesis during ischaemia and reperfusion in the isolated rat hearten_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1681.1989.tb01609.x-
dc.identifier.pmid2805432-
dc.identifier.scopuseid_2-s2.0-0024465152en_US
dc.identifier.volume16en_US
dc.identifier.issue7en_US
dc.identifier.spage591en_US
dc.identifier.epage596en_US
dc.identifier.isiWOS:A1989AP58000005-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridZhan, CY=36967038400en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridLee, AYS=51764125700en_US
dc.identifier.scopusauthoridWong, TM=7403531434en_US
dc.identifier.issnl0305-1870-

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