File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Aging and diurnal rhythms of pineal serotonin, 5-hydroxyindoleacetic acid, norepinephrine, dopamine and serum melatonin in the male rat

TitleAging and diurnal rhythms of pineal serotonin, 5-hydroxyindoleacetic acid, norepinephrine, dopamine and serum melatonin in the male rat
Authors
Keywords5-Hydroxyindoleacetic acid
Aging
Diurnal rhythm
Dopamine
Norepinephrine
Pineal
Serotonin
Serum melatonin
Issue Date1985
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEN
Citation
Neuroendocrinology, 1985, v. 40 n. 2, p. 160-164 How to Cite?
AbstractPineal serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), norepinephrine (NE) and dopamine (DA) were measured by high-pressure liquid chromatography with electrochemical detection and serum melatonin was measured by radioimmunoassay in rats aged 3 weeks, 8 weeks and 18 months. They were killed either at mid-light or mid-dark of a 12 h light:12 h dark cycle. Diurnal rhythms were observed for 5-HT and 5-HIAA in all ages studied while those for NE and DA were not observed in the 18-month-old animals. Pineal 5-HT and 5-HIAA were higher in 3-week-old rats at mid-dark, and lower at mid-light than in older animals. The pineal content of NE was lower in the 3-week-old rats at mid-dark and mid-light compared with that in the 8-week-old while the DA content was lower at mid-dark. In addition, pineal 5-HT, 5-HIAA, NE and DA were lower in the 18-month-old than in the 8-week-old animals at mid-dark. At mid-dark serum melatonin levels showed an age-related decrease. This study shows that an age-related decrease of pineal 5-HT, 5-HIAA, NE and DA can only be demonstrated at mid-dark and that the age-related decrease of melatonin may not be due to a decrease in sympathetic activity.
Persistent Identifierhttp://hdl.handle.net/10722/171494
ISSN
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 1.009
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, Fen_US
dc.contributor.authorHadjiconstantinou, Men_US
dc.contributor.authorPang, SFen_US
dc.date.accessioned2012-10-30T06:15:25Z-
dc.date.available2012-10-30T06:15:25Z-
dc.date.issued1985en_US
dc.identifier.citationNeuroendocrinology, 1985, v. 40 n. 2, p. 160-164en_US
dc.identifier.issn0028-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/171494-
dc.description.abstractPineal serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), norepinephrine (NE) and dopamine (DA) were measured by high-pressure liquid chromatography with electrochemical detection and serum melatonin was measured by radioimmunoassay in rats aged 3 weeks, 8 weeks and 18 months. They were killed either at mid-light or mid-dark of a 12 h light:12 h dark cycle. Diurnal rhythms were observed for 5-HT and 5-HIAA in all ages studied while those for NE and DA were not observed in the 18-month-old animals. Pineal 5-HT and 5-HIAA were higher in 3-week-old rats at mid-dark, and lower at mid-light than in older animals. The pineal content of NE was lower in the 3-week-old rats at mid-dark and mid-light compared with that in the 8-week-old while the DA content was lower at mid-dark. In addition, pineal 5-HT, 5-HIAA, NE and DA were lower in the 18-month-old than in the 8-week-old animals at mid-dark. At mid-dark serum melatonin levels showed an age-related decrease. This study shows that an age-related decrease of pineal 5-HT, 5-HIAA, NE and DA can only be demonstrated at mid-dark and that the age-related decrease of melatonin may not be due to a decrease in sympathetic activity.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NENen_US
dc.relation.ispartofNeuroendocrinologyen_US
dc.subject5-Hydroxyindoleacetic acid-
dc.subjectAging-
dc.subjectDiurnal rhythm-
dc.subjectDopamine-
dc.subjectNorepinephrine-
dc.subjectPineal-
dc.subjectSerotonin-
dc.subjectSerum melatonin-
dc.subject.meshAgingen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChromatography, High Pressure Liquiden_US
dc.subject.meshCircadian Rhythmen_US
dc.subject.meshDopamine - Analysisen_US
dc.subject.meshHydroxyindoleacetic Acid - Analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshMelatonin - Blooden_US
dc.subject.meshNorepinephrine - Analysisen_US
dc.subject.meshPineal Gland - Analysisen_US
dc.subject.meshRadioimmunoassayen_US
dc.subject.meshRatsen_US
dc.titleAging and diurnal rhythms of pineal serotonin, 5-hydroxyindoleacetic acid, norepinephrine, dopamine and serum melatonin in the male raten_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000124068-
dc.identifier.pmid2579346-
dc.identifier.scopuseid_2-s2.0-0021954344en_US
dc.identifier.volume40en_US
dc.identifier.issue2en_US
dc.identifier.spage160en_US
dc.identifier.epage164en_US
dc.identifier.isiWOS:A1985AAC4700010-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridHadjiconstantinou, M=7005377352en_US
dc.identifier.scopusauthoridPang, SF=7402528719en_US
dc.identifier.issnl0028-3835-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats