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- Publisher Website: 10.1111/j.1472-8206.1996.tb00303.x
- Scopus: eid_2-s2.0-8944226111
- PMID: 8836698
- WOS: WOS:A1996UY86600003
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Article: The arterial wall: A new pharmacological and therapeutic target
Title | The arterial wall: A new pharmacological and therapeutic target |
---|---|
Authors | |
Keywords | Angiotensin II receptor antagonists Arterial remodelling Atherosclerosis Endothelin receptor antagonists Endothelium Nitrates NO donors Potassium channel activators Proteoglycans |
Issue Date | 1996 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/FCP |
Citation | Fundamental And Clinical Pharmacology, 1996, v. 10 n. 3, p. 243-257 How to Cite? |
Abstract | In recent years, two key concepts having numerous interrelationships were advanced for the understanding of various cardiovascular diseases: the 'endothelial dysfunction' and the 'arterial remodelling'. Both endothelial dysfunction and arterial remodelling occur in various pathologies including essential hypertension, heart failure, atherosclerosis, restenosis after angioplasty, and pulmonary hypertension, and have modified the therapeutic approach by offering new pharmacological targets: specific receptors not only at the site of the vascular smooth muscle cells but also on the endothelial cells, growth factors that stimulate proliferation of smooth muscle, and receptors and enzymes of the extra-cellular matrix. Among the various substances under research, the present review will discuss angiotensin II receptor antagonists, endothelin receptor antagonists, nitrates-NO donors, potassium channel activators, and substances interfering with proteoglycans and other components of the extra-cellular matrix. |
Persistent Identifier | http://hdl.handle.net/10722/171453 |
ISSN | 2021 Impact Factor: 2.747 2020 SCImago Journal Rankings: 0.655 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Laurent, S | en_US |
dc.contributor.author | Vanhoutte, P | en_US |
dc.contributor.author | Cavero, I | en_US |
dc.contributor.author | Chabrier, PE | en_US |
dc.contributor.author | Dupuis, B | en_US |
dc.contributor.author | Elghozi, JL | en_US |
dc.contributor.author | Hamon, G | en_US |
dc.contributor.author | Janiak, P | en_US |
dc.contributor.author | Juillet, Y | en_US |
dc.contributor.author | Kher, A | en_US |
dc.contributor.author | Koen, R | en_US |
dc.contributor.author | Madonna, O | en_US |
dc.contributor.author | Maffrand, JP | en_US |
dc.contributor.author | Pruneau, D | en_US |
dc.contributor.author | Thuillez, C | en_US |
dc.date.accessioned | 2012-10-30T06:14:22Z | - |
dc.date.available | 2012-10-30T06:14:22Z | - |
dc.date.issued | 1996 | en_US |
dc.identifier.citation | Fundamental And Clinical Pharmacology, 1996, v. 10 n. 3, p. 243-257 | en_US |
dc.identifier.issn | 0767-3981 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171453 | - |
dc.description.abstract | In recent years, two key concepts having numerous interrelationships were advanced for the understanding of various cardiovascular diseases: the 'endothelial dysfunction' and the 'arterial remodelling'. Both endothelial dysfunction and arterial remodelling occur in various pathologies including essential hypertension, heart failure, atherosclerosis, restenosis after angioplasty, and pulmonary hypertension, and have modified the therapeutic approach by offering new pharmacological targets: specific receptors not only at the site of the vascular smooth muscle cells but also on the endothelial cells, growth factors that stimulate proliferation of smooth muscle, and receptors and enzymes of the extra-cellular matrix. Among the various substances under research, the present review will discuss angiotensin II receptor antagonists, endothelin receptor antagonists, nitrates-NO donors, potassium channel activators, and substances interfering with proteoglycans and other components of the extra-cellular matrix. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/FCP | en_US |
dc.relation.ispartof | Fundamental and Clinical Pharmacology | en_US |
dc.subject | Angiotensin II receptor antagonists | - |
dc.subject | Arterial remodelling | - |
dc.subject | Atherosclerosis | - |
dc.subject | Endothelin receptor antagonists | - |
dc.subject | Endothelium | - |
dc.subject | Nitrates | - |
dc.subject | NO donors | - |
dc.subject | Potassium channel activators | - |
dc.subject | Proteoglycans | - |
dc.subject.mesh | Angiotensin Receptor Antagonists | en_US |
dc.subject.mesh | Arteries - Cytology - Drug Effects - Physiopathology | en_US |
dc.subject.mesh | Cardiovascular Diseases - Complications | en_US |
dc.subject.mesh | Endothelium, Vascular - Physiopathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Potassium Channels - Pharmacology | en_US |
dc.subject.mesh | Receptors, Angiotensin - Drug Effects - Physiology | en_US |
dc.subject.mesh | Receptors, Endothelin - Antagonists & Inhibitors - Drug Effects - Physiology | en_US |
dc.title | The arterial wall: A new pharmacological and therapeutic target | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, P:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, P=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1472-8206.1996.tb00303.x | - |
dc.identifier.pmid | 8836698 | - |
dc.identifier.scopus | eid_2-s2.0-8944226111 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-8944226111&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 243 | en_US |
dc.identifier.epage | 257 | en_US |
dc.identifier.isi | WOS:A1996UY86600003 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Laurent, S=7102779577 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, P=7202304247 | en_US |
dc.identifier.scopusauthorid | Cavero, I=7006668310 | en_US |
dc.identifier.scopusauthorid | Chabrier, PE=7005988764 | en_US |
dc.identifier.scopusauthorid | Dupuis, B=7005189900 | en_US |
dc.identifier.scopusauthorid | Elghozi, JL=7006937210 | en_US |
dc.identifier.scopusauthorid | Hamon, G=7003320119 | en_US |
dc.identifier.scopusauthorid | Janiak, P=6603686655 | en_US |
dc.identifier.scopusauthorid | Juillet, Y=7005174082 | en_US |
dc.identifier.scopusauthorid | Kher, A=36917111000 | en_US |
dc.identifier.scopusauthorid | Koen, R=6603112958 | en_US |
dc.identifier.scopusauthorid | Madonna, O=6602744871 | en_US |
dc.identifier.scopusauthorid | Maffrand, JP=7005521190 | en_US |
dc.identifier.scopusauthorid | Pruneau, D=7005510301 | en_US |
dc.identifier.scopusauthorid | Thuillez, C=7005267110 | en_US |
dc.identifier.issnl | 0767-3981 | - |