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- Publisher Website: 10.1124/jpet.103.063388
- Scopus: eid_2-s2.0-2442669009
- PMID: 14764658
- WOS: WOS:000221640900036
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Article: Potassium canrenoate, an aldosterone receptor antagonist, reduces isoprenaline-induced cardiac fibrosis in the rat
Title | Potassium canrenoate, an aldosterone receptor antagonist, reduces isoprenaline-induced cardiac fibrosis in the rat |
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Authors | |
Issue Date | 2004 |
Publisher | American Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org |
Citation | Journal Of Pharmacology And Experimental Therapeutics, 2004, v. 309 n. 3, p. 1160-1166 How to Cite? |
Abstract | The purpose of the present study was to determine whether the administration of an antagonist of aldosterone could prevent the fibrosis induced by an acute injection of isoprenaline. Male Wistar rats were submitted to one subcutaneous injection of isoprenaline (400 mg/kg) and were simultaneously treated with potassium canrenoate in drinking water (20 mg/kg/day) started 5 days before the injection of isoprenaline. Two months later, echocardiographic and hemodynamic measurements were performed. Then, the heart was prepared for morphometric histology and quantification of fibrosis in the left ventricle. Heart and left ventricular weights were increased significantly by isoprenaline. Potassium canrenoate attenuated this increase. The administration of isoprenaline increased significantly end diastolic diameter and end systolic volume compared with control. These changes were increased further with the addition of potassium canrenoate. In contrast, the fibrosis induced by isoprenaline was reduced significantly by potassium canrenoate at the three section levels. Potassium canrenoate attenuated the fibrosis but not the enhanced dilatation of the left ventricle induced by isoprenaline. |
Persistent Identifier | http://hdl.handle.net/10722/171334 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.829 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bos, R | en_US |
dc.contributor.author | Mougenot, N | en_US |
dc.contributor.author | Médiani, O | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | Lechat, P | en_US |
dc.date.accessioned | 2012-10-30T06:13:27Z | - |
dc.date.available | 2012-10-30T06:13:27Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Journal Of Pharmacology And Experimental Therapeutics, 2004, v. 309 n. 3, p. 1160-1166 | en_US |
dc.identifier.issn | 0022-3565 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171334 | - |
dc.description.abstract | The purpose of the present study was to determine whether the administration of an antagonist of aldosterone could prevent the fibrosis induced by an acute injection of isoprenaline. Male Wistar rats were submitted to one subcutaneous injection of isoprenaline (400 mg/kg) and were simultaneously treated with potassium canrenoate in drinking water (20 mg/kg/day) started 5 days before the injection of isoprenaline. Two months later, echocardiographic and hemodynamic measurements were performed. Then, the heart was prepared for morphometric histology and quantification of fibrosis in the left ventricle. Heart and left ventricular weights were increased significantly by isoprenaline. Potassium canrenoate attenuated this increase. The administration of isoprenaline increased significantly end diastolic diameter and end systolic volume compared with control. These changes were increased further with the addition of potassium canrenoate. In contrast, the fibrosis induced by isoprenaline was reduced significantly by potassium canrenoate at the three section levels. Potassium canrenoate attenuated the fibrosis but not the enhanced dilatation of the left ventricle induced by isoprenaline. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org | en_US |
dc.relation.ispartof | Journal of Pharmacology and Experimental Therapeutics | en_US |
dc.subject.mesh | Aldosterone Antagonists - Therapeutic Use | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Pressure - Drug Effects | en_US |
dc.subject.mesh | Canrenoate Potassium - Therapeutic Use | en_US |
dc.subject.mesh | Cardiomyopathies - Chemically Induced - Drug Therapy - Mortality - Physiopathology | en_US |
dc.subject.mesh | Disease Models, Animal | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Fibrosis - Blood - Chemically Induced - Drug Therapy - Mortality - Physiopathology | en_US |
dc.subject.mesh | Heart Rate - Drug Effects | en_US |
dc.subject.mesh | Isoproterenol | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Neurotransmitter Agents - Blood | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Wistar | en_US |
dc.subject.mesh | Receptors, Aldosterone - Antagonists & Inhibitors | en_US |
dc.title | Potassium canrenoate, an aldosterone receptor antagonist, reduces isoprenaline-induced cardiac fibrosis in the rat | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1124/jpet.103.063388 | en_US |
dc.identifier.pmid | 14764658 | - |
dc.identifier.scopus | eid_2-s2.0-2442669009 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-2442669009&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 309 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 1160 | en_US |
dc.identifier.epage | 1166 | en_US |
dc.identifier.isi | WOS:000221640900036 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Bos, R=7102085925 | en_US |
dc.identifier.scopusauthorid | Mougenot, N=6602996596 | en_US |
dc.identifier.scopusauthorid | Médiani, O=6507974261 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.scopusauthorid | Lechat, P=7102784631 | en_US |
dc.identifier.issnl | 0022-3565 | - |