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Article: Augmented pulmonary vascular and venous constrictions to N G-nitro-L-arginine methyl ester in rats with monocrotaline-induced pulmonary hypertension

TitleAugmented pulmonary vascular and venous constrictions to N G-nitro-L-arginine methyl ester in rats with monocrotaline-induced pulmonary hypertension
Authors
KeywordsBlood pressure
Cardiac output
Nitric oxide
Pulmonary vascular resistance
Pyrrolizidine alkaloid
Systemic vascular resistance
Issue Date2003
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/PHA
Citation
Pharmacology, 2003, v. 69 n. 3, p. 164-170 How to Cite?
AbstractThe hemodynamic effects of NG-nitro-L-arginine methyl ester (L-NAME, inhibitor of nitric oxide (NO) synthase) were examined in thiobutabarbital-anesthetized control- rats and rats with monocrotaline-induced pulmonary hypertension. L-NAME (1-16 mg/kg i.v.) increased mean arterial pressure, systemic vascular resistance, venous resistance and pulmonary vascular resistance, and decreased cardiac output in both the control and pulmonary hypertensive rats. Relative to the controls, L-NAME (16 mg/kg) caused a smaller increase (≈50% of control) in mean arterial pressure in the pulmonary hypertensive rats, but greater increases in venous (≈200%) as well as pulmonary vascular (≈400%) resistances and a greater decrease in cardiac output (≈140%). The results show that NO is an important dilator within the arterial, venous and pulmonary circulation; its pulmonary and venous dilator roles are augmented in pulmonary hypertension. Copyright © 2003 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/171301
ISSN
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 0.679
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, SWSen_US
dc.contributor.authorCheng, Xen_US
dc.contributor.authorLim, SLen_US
dc.contributor.authorPang, CCYen_US
dc.date.accessioned2012-10-30T06:13:16Z-
dc.date.available2012-10-30T06:13:16Z-
dc.date.issued2003en_US
dc.identifier.citationPharmacology, 2003, v. 69 n. 3, p. 164-170en_US
dc.identifier.issn0031-7012en_US
dc.identifier.urihttp://hdl.handle.net/10722/171301-
dc.description.abstractThe hemodynamic effects of NG-nitro-L-arginine methyl ester (L-NAME, inhibitor of nitric oxide (NO) synthase) were examined in thiobutabarbital-anesthetized control- rats and rats with monocrotaline-induced pulmonary hypertension. L-NAME (1-16 mg/kg i.v.) increased mean arterial pressure, systemic vascular resistance, venous resistance and pulmonary vascular resistance, and decreased cardiac output in both the control and pulmonary hypertensive rats. Relative to the controls, L-NAME (16 mg/kg) caused a smaller increase (≈50% of control) in mean arterial pressure in the pulmonary hypertensive rats, but greater increases in venous (≈200%) as well as pulmonary vascular (≈400%) resistances and a greater decrease in cardiac output (≈140%). The results show that NO is an important dilator within the arterial, venous and pulmonary circulation; its pulmonary and venous dilator roles are augmented in pulmonary hypertension. Copyright © 2003 S. Karger AG, Basel.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/PHAen_US
dc.relation.ispartofPharmacologyen_US
dc.subjectBlood pressure-
dc.subjectCardiac output-
dc.subjectNitric oxide-
dc.subjectPulmonary vascular resistance-
dc.subjectPyrrolizidine alkaloid-
dc.subjectSystemic vascular resistance-
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshHypertension, Pulmonary - Drug Therapy - Metabolism - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMonocrotalineen_US
dc.subject.meshNg-Nitroarginine Methyl Ester - Pharmacologyen_US
dc.subject.meshNitric Oxide - Antagonists & Inhibitorsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshVascular Resistance - Drug Effectsen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.titleAugmented pulmonary vascular and venous constrictions to N G-nitro-L-arginine methyl ester in rats with monocrotaline-induced pulmonary hypertensionen_US
dc.typeArticleen_US
dc.identifier.emailLeung, SWS:swsleung@hku.hken_US
dc.identifier.authorityLeung, SWS=rp00235en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000072670en_US
dc.identifier.pmid14512704-
dc.identifier.scopuseid_2-s2.0-0141649457en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141649457&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume69en_US
dc.identifier.issue3en_US
dc.identifier.spage164en_US
dc.identifier.epage170en_US
dc.identifier.isiWOS:000185887800009-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridLeung, SWS=24540419500en_US
dc.identifier.scopusauthoridCheng, X=37044433300en_US
dc.identifier.scopusauthoridLim, SL=7404080728en_US
dc.identifier.scopusauthoridPang, CCY=7201425219en_US
dc.identifier.issnl0031-7012-

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