File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1023/A:1007090113551
- Scopus: eid_2-s2.0-0034096281
- PMID: 10888228
- WOS: WOS:000087113200010
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Acetylcholine-mediated relaxation in rat thoracic aorta is enhanced following acute exposure to physiological concentrations of 17β-estradiol
Title | Acetylcholine-mediated relaxation in rat thoracic aorta is enhanced following acute exposure to physiological concentrations of 17β-estradiol |
---|---|
Authors | |
Keywords | 17β-estradiol Acetylcholine Endothelium-dependent relaxation Rat aorta |
Issue Date | 2000 |
Publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177 |
Citation | Molecular And Cellular Biochemistry, 2000, v. 207 n. 1-2, p. 65-70 How to Cite? |
Abstract | We investigated the effects of short-term exposure to low concentrations of 17β-estradiol on vasorelaxation using an in vitro rat thoracic aortic ring preparation. Supraphysiological levels of 17β-estradiol directly relaxed phenylephrine-contracted rings. Although acute incubation (20 min) with 1-100 nM of the female sex hormone did not have any significant effect on phenylephrine-contracted rings, relaxation evoked by acetylcholine was significantly potentiated. In contrast, calcium ionophore A23187-elicited endothelium-dependent relaxation as well as cromakalim- and sodium nitroprusside-mediated endothelium-independent relaxation was unchanged following the same regime with 17β-estradiol. These results demonstrate that short-term treatment with physiologically relevant levels of 17β-estradiol, which on their own have no effect, enhances endothelium-dependent relaxation by acetylcholine. The vascular effects observed herein may partly account for some of the improved acute vasodilatory responses reported with 17β- estradiol on blood flow in humans. |
Persistent Identifier | http://hdl.handle.net/10722/171244 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 0.901 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Teoh, H | en_US |
dc.contributor.author | Leung, SWS | en_US |
dc.contributor.author | Quan, A | en_US |
dc.contributor.author | Huang, M | en_US |
dc.contributor.author | Man, GSK | en_US |
dc.contributor.author | Man, RYK | en_US |
dc.date.accessioned | 2012-10-30T06:12:55Z | - |
dc.date.available | 2012-10-30T06:12:55Z | - |
dc.date.issued | 2000 | en_US |
dc.identifier.citation | Molecular And Cellular Biochemistry, 2000, v. 207 n. 1-2, p. 65-70 | en_US |
dc.identifier.issn | 0300-8177 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171244 | - |
dc.description.abstract | We investigated the effects of short-term exposure to low concentrations of 17β-estradiol on vasorelaxation using an in vitro rat thoracic aortic ring preparation. Supraphysiological levels of 17β-estradiol directly relaxed phenylephrine-contracted rings. Although acute incubation (20 min) with 1-100 nM of the female sex hormone did not have any significant effect on phenylephrine-contracted rings, relaxation evoked by acetylcholine was significantly potentiated. In contrast, calcium ionophore A23187-elicited endothelium-dependent relaxation as well as cromakalim- and sodium nitroprusside-mediated endothelium-independent relaxation was unchanged following the same regime with 17β-estradiol. These results demonstrate that short-term treatment with physiologically relevant levels of 17β-estradiol, which on their own have no effect, enhances endothelium-dependent relaxation by acetylcholine. The vascular effects observed herein may partly account for some of the improved acute vasodilatory responses reported with 17β- estradiol on blood flow in humans. | en_US |
dc.language | eng | en_US |
dc.publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177 | en_US |
dc.relation.ispartof | Molecular and Cellular Biochemistry | en_US |
dc.subject | 17β-estradiol | - |
dc.subject | Acetylcholine | - |
dc.subject | Endothelium-dependent relaxation | - |
dc.subject | Rat aorta | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Aorta, Thoracic - Drug Effects - Physiology | en_US |
dc.subject.mesh | Calcimycin - Pharmacology | en_US |
dc.subject.mesh | Cromakalim - Pharmacology | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Estradiol - Pharmacology | en_US |
dc.subject.mesh | Ionophores - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Muscle Relaxation | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects - Physiology | en_US |
dc.subject.mesh | Nitroprusside - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Vasodilation - Physiology | en_US |
dc.subject.mesh | Vasodilator Agents - Pharmacology | en_US |
dc.title | Acetylcholine-mediated relaxation in rat thoracic aorta is enhanced following acute exposure to physiological concentrations of 17β-estradiol | en_US |
dc.type | Article | en_US |
dc.identifier.email | Leung, SWS:swsleung@hku.hk | en_US |
dc.identifier.email | Man, RYK:rykman@hkucc.hku.hk | en_US |
dc.identifier.authority | Leung, SWS=rp00235 | en_US |
dc.identifier.authority | Man, RYK=rp00236 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1023/A:1007090113551 | - |
dc.identifier.pmid | 10888228 | - |
dc.identifier.scopus | eid_2-s2.0-0034096281 | en_US |
dc.identifier.hkuros | 50470 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034096281&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 207 | en_US |
dc.identifier.issue | 1-2 | en_US |
dc.identifier.spage | 65 | en_US |
dc.identifier.epage | 70 | en_US |
dc.identifier.isi | WOS:000087113200010 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Teoh, H=7003816542 | en_US |
dc.identifier.scopusauthorid | Leung, SWS=24540419500 | en_US |
dc.identifier.scopusauthorid | Quan, A=7006871453 | en_US |
dc.identifier.scopusauthorid | Huang, M=55198346200 | en_US |
dc.identifier.scopusauthorid | Man, GSK=7003741547 | en_US |
dc.identifier.scopusauthorid | Man, RYK=7004986435 | en_US |
dc.identifier.issnl | 0300-8177 | - |