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- Publisher Website: 10.1016/S0891-5849(99)00086-6
- Scopus: eid_2-s2.0-0032589236
- PMID: 10468219
- WOS: WOS:000082107500025
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Article: Low concentrations of 17β-estradiol reduce oxidative modification of low-density lipoproteins in the presence of vitamin C and vitamin E
Title | Low concentrations of 17β-estradiol reduce oxidative modification of low-density lipoproteins in the presence of vitamin C and vitamin E |
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Authors | |
Keywords | Antioxidants Estradiol Free Radicals Lipid Peroxidation Lipoproteins Vitamin C Vitamin E |
Issue Date | 1999 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed |
Citation | Free Radical Biology And Medicine, 1999, v. 27 n. 3-4, p. 438-441 How to Cite? |
Abstract | Micromolar concentrations of estradiol are required to inhibit the oxidation of low-density lipoproteins (LDL) in vitro. Recent evidence suggests that estradiol must be modified before it can become an effective antioxidant at physiological levels. Our aim was to determine other possible conditions under which low concentrations of 17β-estradiol can reduce LDL oxidation. LDL susceptibility to oxidation was monitored by measurements of conjugated diene formation. High levels of 17β-estradiol reduced oxidative modification of LDL. Vitamin C and vitamin E also increased LDL resistance to Cu 2+-mediated oxidation. More importantly, 10 nM 17β-estradiol, which on its own had no effect, exhibited significant antioxidant actions in the presence of either vitamins C or E. In conclusion, supraphysiological concentrations of 17β-estradiol are required to exert antioxidant effects directly in vitro. However, in the presence of vitamins C and E, concentrations of 17β-estradiol close to physiological levels can also protect LDL from oxidation. |
Persistent Identifier | http://hdl.handle.net/10722/171217 |
ISSN | 2023 Impact Factor: 7.1 2023 SCImago Journal Rankings: 1.752 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Huang, M | en_US |
dc.contributor.author | Li, J | en_US |
dc.contributor.author | Teoh, H | en_US |
dc.contributor.author | Man, RYK | en_US |
dc.date.accessioned | 2012-10-30T06:12:46Z | - |
dc.date.available | 2012-10-30T06:12:46Z | - |
dc.date.issued | 1999 | en_US |
dc.identifier.citation | Free Radical Biology And Medicine, 1999, v. 27 n. 3-4, p. 438-441 | en_US |
dc.identifier.issn | 0891-5849 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171217 | - |
dc.description.abstract | Micromolar concentrations of estradiol are required to inhibit the oxidation of low-density lipoproteins (LDL) in vitro. Recent evidence suggests that estradiol must be modified before it can become an effective antioxidant at physiological levels. Our aim was to determine other possible conditions under which low concentrations of 17β-estradiol can reduce LDL oxidation. LDL susceptibility to oxidation was monitored by measurements of conjugated diene formation. High levels of 17β-estradiol reduced oxidative modification of LDL. Vitamin C and vitamin E also increased LDL resistance to Cu 2+-mediated oxidation. More importantly, 10 nM 17β-estradiol, which on its own had no effect, exhibited significant antioxidant actions in the presence of either vitamins C or E. In conclusion, supraphysiological concentrations of 17β-estradiol are required to exert antioxidant effects directly in vitro. However, in the presence of vitamins C and E, concentrations of 17β-estradiol close to physiological levels can also protect LDL from oxidation. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed | en_US |
dc.relation.ispartof | Free Radical Biology and Medicine | en_US |
dc.rights | Free Radical Biology & Medicine. Copyright © Elsevier Inc. | - |
dc.subject | Antioxidants | en_US |
dc.subject | Estradiol | en_US |
dc.subject | Free Radicals | en_US |
dc.subject | Lipid Peroxidation | en_US |
dc.subject | Lipoproteins | en_US |
dc.subject | Vitamin C | en_US |
dc.subject | Vitamin E | en_US |
dc.title | Low concentrations of 17β-estradiol reduce oxidative modification of low-density lipoproteins in the presence of vitamin C and vitamin E | en_US |
dc.type | Article | en_US |
dc.identifier.email | Man, RYK:rykman@hkucc.hku.hk | en_US |
dc.identifier.authority | Man, RYK=rp00236 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0891-5849(99)00086-6 | en_US |
dc.identifier.pmid | 10468219 | - |
dc.identifier.scopus | eid_2-s2.0-0032589236 | en_US |
dc.identifier.hkuros | 46189 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032589236&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 3-4 | en_US |
dc.identifier.spage | 438 | en_US |
dc.identifier.epage | 441 | en_US |
dc.identifier.isi | WOS:000082107500025 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Huang, M=55198346200 | en_US |
dc.identifier.scopusauthorid | Li, J=12796026200 | en_US |
dc.identifier.scopusauthorid | Teoh, H=7003816542 | en_US |
dc.identifier.scopusauthorid | Man, RYK=7004986435 | en_US |
dc.identifier.issnl | 0891-5849 | - |