File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Rechallenge with lamotrigine after initial rash

TitleRechallenge with lamotrigine after initial rash
Authors
Keywordsadverse reaction
drug rechallenge
lamotrigine
skin rash
Issue Date1995
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/seizure
Citation
Seizure, 1995, v. 4 n. 1, p. 67-71 How to Cite?
AbstractEight patients rechallenged with lamotrigine after initial exposure which resulted in a skin rash are reported. On reintroduction of the lamotrigine, six of the patients had no recurrence of the rash. Of the other two patients, one had the occurrence of a mild fluctuating and qualitatively different skin rash on rechallenge. The other patient had developed a dose-related rash on initial challenge resulting in a dose reduction. The first attempt to re-increase the dose resulted in reappearance of the rash which again disappeared on dose reduction. However a further attempt to re-increase the dose did not result in reappearance of a rash. It is suggested that patients who experience a rash but good therapeutic response to lamotrigine might be considered for re-dosing.
Persistent Identifierhttp://hdl.handle.net/10722/171158
ISSN
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.847

 

DC FieldValueLanguage
dc.contributor.authorTavenor, SJen_US
dc.contributor.authorWong, ICKen_US
dc.contributor.authorNewton, Ren_US
dc.contributor.authorBrown, SWen_US
dc.date.accessioned2012-10-30T06:12:27Z-
dc.date.available2012-10-30T06:12:27Z-
dc.date.issued1995en_US
dc.identifier.citationSeizure, 1995, v. 4 n. 1, p. 67-71en_US
dc.identifier.issn1059-1311en_US
dc.identifier.urihttp://hdl.handle.net/10722/171158-
dc.description.abstractEight patients rechallenged with lamotrigine after initial exposure which resulted in a skin rash are reported. On reintroduction of the lamotrigine, six of the patients had no recurrence of the rash. Of the other two patients, one had the occurrence of a mild fluctuating and qualitatively different skin rash on rechallenge. The other patient had developed a dose-related rash on initial challenge resulting in a dose reduction. The first attempt to re-increase the dose resulted in reappearance of the rash which again disappeared on dose reduction. However a further attempt to re-increase the dose did not result in reappearance of a rash. It is suggested that patients who experience a rash but good therapeutic response to lamotrigine might be considered for re-dosing.en_US
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/seizureen_US
dc.relation.ispartofSeizureen_US
dc.subjectadverse reaction-
dc.subjectdrug rechallenge-
dc.subjectlamotrigine-
dc.subjectskin rash-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnticonvulsants - Administration & Dosage - Adverse Effectsen_US
dc.subject.meshChilden_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshDrug Eruptions - Diagnosisen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshEpilepsy - Drug Therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRecurrenceen_US
dc.subject.meshTriazines - Administration & Dosage - Adverse Effectsen_US
dc.titleRechallenge with lamotrigine after initial rashen_US
dc.typeArticleen_US
dc.identifier.emailWong, ICK:wongick@hku.hken_US
dc.identifier.authorityWong, ICK=rp01480en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S1059-1311(05)80082-2en_US
dc.identifier.pmid7788112-
dc.identifier.scopuseid_2-s2.0-0028933226en_US
dc.identifier.volume4en_US
dc.identifier.issue1en_US
dc.identifier.spage67en_US
dc.identifier.epage71en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTavenor, SJ=6504612831en_US
dc.identifier.scopusauthoridWong, ICK=7102513915en_US
dc.identifier.scopusauthoridNewton, R=7401830962en_US
dc.identifier.scopusauthoridBrown, SW=35355111600en_US
dc.identifier.issnl1059-1311-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats