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- Publisher Website: 10.1016/0006-291X(92)91681-F
- Scopus: eid_2-s2.0-0026753665
- PMID: 1376991
- WOS: WOS:A1992HZ25200031
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Article: Kinins mediate kallikrein-induced endothelium-dependent relaxations in isolated canine coronary arteries
Title | Kinins mediate kallikrein-induced endothelium-dependent relaxations in isolated canine coronary arteries |
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Authors | |
Issue Date | 1992 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description |
Citation | Biochemical And Biophysical Research Communications, 1992, v. 185 n. 2, p. 693-697 How to Cite? |
Abstract | ACE inhibitors elicit the release of endothelium-derived relaxing factors in perfused isolated canine arteries (Mombouli and Vanhoutte, J. Cardiovasc. Pharmacol. 1991, 18: 926-927); this action is antagonized by bradykinin- receptor antagonists suggesting that it is mediated by local kinin generation. The effects of exogenous tissular kallikrein (porcine) were examined in vitro in the isolated canine coronary artery. Isometric tension was measured in blood vessel rings (with and without endothelium) contracted with prostaglandin F(2α). The kallikrein elicited relaxations in rings with, but not in those without, endothelium. This response was augmented by the angiotensin converting enzyme inhibitor perindoprilat, and it was antagonized by the selective B2-kinin receptor antagonist HOE 140 and aprotinin, an inhibitor of tissular kallikrein. These data suggest that in the canine coronary artery, kallikrein causes relaxations that may be mediated by kinins generated from endogenous kininogens present in the vascular wall. |
Persistent Identifier | http://hdl.handle.net/10722/171072 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.770 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Mombouli, JV | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:12:05Z | - |
dc.date.available | 2012-10-30T06:12:05Z | - |
dc.date.issued | 1992 | en_US |
dc.identifier.citation | Biochemical And Biophysical Research Communications, 1992, v. 185 n. 2, p. 693-697 | en_US |
dc.identifier.issn | 0006-291X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171072 | - |
dc.description.abstract | ACE inhibitors elicit the release of endothelium-derived relaxing factors in perfused isolated canine arteries (Mombouli and Vanhoutte, J. Cardiovasc. Pharmacol. 1991, 18: 926-927); this action is antagonized by bradykinin- receptor antagonists suggesting that it is mediated by local kinin generation. The effects of exogenous tissular kallikrein (porcine) were examined in vitro in the isolated canine coronary artery. Isometric tension was measured in blood vessel rings (with and without endothelium) contracted with prostaglandin F(2α). The kallikrein elicited relaxations in rings with, but not in those without, endothelium. This response was augmented by the angiotensin converting enzyme inhibitor perindoprilat, and it was antagonized by the selective B2-kinin receptor antagonist HOE 140 and aprotinin, an inhibitor of tissular kallikrein. These data suggest that in the canine coronary artery, kallikrein causes relaxations that may be mediated by kinins generated from endogenous kininogens present in the vascular wall. | en_US |
dc.language | eng | en_US |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description | en_US |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Aprotinin - Pharmacology | en_US |
dc.subject.mesh | Bradykinin - Analogs & Derivatives | en_US |
dc.subject.mesh | Coronary Vessels | en_US |
dc.subject.mesh | Dinoprost - Pharmacology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium, Vascular - Physiology | en_US |
dc.subject.mesh | Indoles - Pharmacology | en_US |
dc.subject.mesh | Kallikreins - Pharmacology | en_US |
dc.subject.mesh | Kinins - Pharmacology | en_US |
dc.subject.mesh | Oligopeptides - Pharmacology | en_US |
dc.subject.mesh | Receptors, Bradykinin | en_US |
dc.subject.mesh | Receptors, Neurotransmitter - Drug Effects | en_US |
dc.subject.mesh | Vasodilation - Drug Effects | en_US |
dc.title | Kinins mediate kallikrein-induced endothelium-dependent relaxations in isolated canine coronary arteries | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0006-291X(92)91681-F | en_US |
dc.identifier.pmid | 1376991 | - |
dc.identifier.scopus | eid_2-s2.0-0026753665 | en_US |
dc.identifier.volume | 185 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 693 | en_US |
dc.identifier.epage | 697 | en_US |
dc.identifier.isi | WOS:A1992HZ25200031 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Mombouli, JV=7004285772 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0006-291X | - |