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Article: The effect of methyl-lidocaine on the biosynthesis of phospholipids de novo in the isolated hamster heart

TitleThe effect of methyl-lidocaine on the biosynthesis of phospholipids de novo in the isolated hamster heart
Authors
Tardi, PGMan, RYKChoy, PC
Issue Date1992
PublisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.org
Citation
Biochemical Journal, 1992, v. 285 n. 1, p. 161-166 How to Cite?
DOI: http://dx.doi.org/10.1042/bj2850161
AbstractMethyl-lidocaine is an amphiphilic agent which has been used as an experimental anti-arrhythmic drug. When hamster hearts were perfused with labelled glycerol, the presence of methyl-lidocaine in the perfusate was found to enhance the labelling in phosphatidylserine, phosphatidylinositol, diacylglycerol and triacylglycerol. However, the labelling of phosphatidylcholine and phosphatidylethanolamine was not significantly changed by methyl-lidocaine treatment. Assays in vitro for the enzymes involved in the synthesis of neutral lipids and acidic phospholipids revealed that phosphatidate phosphatase and CTP:phosphatidate cytidylyltransferase activities were stimulated by methyl-lidocaine. The intracellular pool sizes of diacylglycerol and CDP-diacylglycerol were also elevated. We postulate that the enhanced syntheses of the neutral lipids and acidic phospholipids in the methyl-lidocaine-perfused heart were mediated via the direct activation of the key enzymes in the biosynthesis of these lipids de noco.
Persistent Identifierhttp://hdl.handle.net/10722/171065
ISSN
0264-6021
2023 Impact Factor: 4.4
2023 SCImago Journal Rankings: 1.612
ISI Accession Number ID
WOS:A1992JC92400027

 

DC FieldValueLanguage
dc.contributor.authorTardi, PGen_US
dc.contributor.authorMan, RYKen_US
dc.contributor.authorChoy, PCen_US
dc.date.accessioned2012-10-30T06:12:03Z-
dc.date.available2012-10-30T06:12:03Z-
dc.date.issued1992en_US
dc.identifier.citationBiochemical Journal, 1992, v. 285 n. 1, p. 161-166en_US
dc.identifier.issn0264-6021en_US
dc.identifier.urihttp://hdl.handle.net/10722/171065-
dc.description.abstractMethyl-lidocaine is an amphiphilic agent which has been used as an experimental anti-arrhythmic drug. When hamster hearts were perfused with labelled glycerol, the presence of methyl-lidocaine in the perfusate was found to enhance the labelling in phosphatidylserine, phosphatidylinositol, diacylglycerol and triacylglycerol. However, the labelling of phosphatidylcholine and phosphatidylethanolamine was not significantly changed by methyl-lidocaine treatment. Assays in vitro for the enzymes involved in the synthesis of neutral lipids and acidic phospholipids revealed that phosphatidate phosphatase and CTP:phosphatidate cytidylyltransferase activities were stimulated by methyl-lidocaine. The intracellular pool sizes of diacylglycerol and CDP-diacylglycerol were also elevated. We postulate that the enhanced syntheses of the neutral lipids and acidic phospholipids in the methyl-lidocaine-perfused heart were mediated via the direct activation of the key enzymes in the biosynthesis of these lipids de noco.en_US
dc.languageengen_US
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.orgen_US
dc.relation.ispartofBiochemical Journalen_US
dc.subject.meshAcyl Coenzyme A - Metabolismen_US
dc.subject.meshAcyltransferases - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Arrhythmia Agents - Pharmacologyen_US
dc.subject.meshChlorpromazine - Pharmacologyen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshDiacylglycerol O-Acyltransferaseen_US
dc.subject.meshDiglycerides - Metabolismen_US
dc.subject.meshGlycerol-3-Phosphate O-Acyltransferase - Metabolismen_US
dc.subject.meshHeart - Drug Effectsen_US
dc.subject.meshLidocaine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshMesocricetusen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshNucleotidyltransferases - Metabolismen_US
dc.subject.meshPhosphatidate Phosphatase - Metabolismen_US
dc.subject.meshPhospholipids - Biosynthesis - Metabolismen_US
dc.subject.meshTriglycerides - Metabolismen_US
dc.titleThe effect of methyl-lidocaine on the biosynthesis of phospholipids de novo in the isolated hamster hearten_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1042/bj2850161-
dc.identifier.pmid1322123-
dc.identifier.scopuseid_2-s2.0-0026689241en_US
dc.identifier.volume285en_US
dc.identifier.issue1en_US
dc.identifier.spage161en_US
dc.identifier.epage166en_US
dc.identifier.isiWOS:A1992JC92400027-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTardi, PG=36805754700en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US
dc.identifier.scopusauthoridChoy, PC=7006633002en_US
dc.identifier.issnl0264-6021-

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