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Article: Hypoxic contraction of canine coronary arteries: Role of endothelium and cGMP
Title | Hypoxic contraction of canine coronary arteries: Role of endothelium and cGMP |
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Authors | |
Keywords | Anoxia Cyclooxygenase inhibition Endothelium-derived factors Vascular smooth muscle |
Issue Date | 1991 |
Publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ |
Citation | American Journal Of Physiology - Heart And Circulatory Physiology, 1991, v. 261 n. 6 30-6, p. H1769-H1777 How to Cite? |
Abstract | The effect of severe hypoxia in quiescent or contracted (prostaglandin F(2α)) canine coronary artery rings with and without endothelium was studied. Hypoxia induced an initial transient relaxation followed by a sustained contraction. The hypoxic contraction in quiescent rings was comparable in rings with and without endothelium. The facilitation of the contraction to prostaglandin F(2α) was more pronounced in rings with endothelium. Increasing the level of contractions by augmenting the contraction of prostaglandin F(2α) potentiated the hypoxic contraction in rings with endothelium only. Methylene blue, LY 83583, and nitro-L-arginine reversed the hypoxic facilitation in contracted rings into relaxation, whereas M and B 22948 augmented it. In quiescent coronary preparations, methylene blue reversed the hypoxic contraction into relaxation in preparations with and without endothelium, whereas nitro-L-arginine had the same effect in vessels with endothelium only. SIN-1, nitroglycerin, and dibutyryl guanosine 3',5'-cyclic monophosphate (cGMP) unmasked hypoxic facilitation in rings without endothelium. This was not observed with isoproterenol. The measurement of the level of cGMP revealed an increased level in rings with endothelium compared with those without endothelium under control oxygenation. This difference disappeared during hypoxia due to a decrease of cGMP content in vessels with endothelium. The results suggest that a moderate increase of the cGMP level in vascular smooth muscle is a prerequisite for the occurrence of hypoxia-induced facilitation in contracted canine coronary arteries. |
Persistent Identifier | http://hdl.handle.net/10722/171036 |
ISSN |
DC Field | Value | Language |
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dc.contributor.author | Graser, T | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:55Z | - |
dc.date.available | 2012-10-30T06:11:55Z | - |
dc.date.issued | 1991 | en_US |
dc.identifier.citation | American Journal Of Physiology - Heart And Circulatory Physiology, 1991, v. 261 n. 6 30-6, p. H1769-H1777 | en_US |
dc.identifier.issn | 0002-9513 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171036 | - |
dc.description.abstract | The effect of severe hypoxia in quiescent or contracted (prostaglandin F(2α)) canine coronary artery rings with and without endothelium was studied. Hypoxia induced an initial transient relaxation followed by a sustained contraction. The hypoxic contraction in quiescent rings was comparable in rings with and without endothelium. The facilitation of the contraction to prostaglandin F(2α) was more pronounced in rings with endothelium. Increasing the level of contractions by augmenting the contraction of prostaglandin F(2α) potentiated the hypoxic contraction in rings with endothelium only. Methylene blue, LY 83583, and nitro-L-arginine reversed the hypoxic facilitation in contracted rings into relaxation, whereas M and B 22948 augmented it. In quiescent coronary preparations, methylene blue reversed the hypoxic contraction into relaxation in preparations with and without endothelium, whereas nitro-L-arginine had the same effect in vessels with endothelium only. SIN-1, nitroglycerin, and dibutyryl guanosine 3',5'-cyclic monophosphate (cGMP) unmasked hypoxic facilitation in rings without endothelium. This was not observed with isoproterenol. The measurement of the level of cGMP revealed an increased level in rings with endothelium compared with those without endothelium under control oxygenation. This difference disappeared during hypoxia due to a decrease of cGMP content in vessels with endothelium. The results suggest that a moderate increase of the cGMP level in vascular smooth muscle is a prerequisite for the occurrence of hypoxia-induced facilitation in contracted canine coronary arteries. | en_US |
dc.language | eng | en_US |
dc.publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ | en_US |
dc.relation.ispartof | American Journal of Physiology - Heart and Circulatory Physiology | en_US |
dc.subject | Anoxia | - |
dc.subject | Cyclooxygenase inhibition | - |
dc.subject | Endothelium-derived factors | - |
dc.subject | Vascular smooth muscle | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anoxia - Physiopathology | en_US |
dc.subject.mesh | Arginine - Analogs & Derivatives - Pharmacology | en_US |
dc.subject.mesh | Coronary Vessels - Physiopathology | en_US |
dc.subject.mesh | Cyclic Gmp - Physiology | en_US |
dc.subject.mesh | Dinoprost - Pharmacology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium, Vascular - Physiopathology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Methylene Blue - Pharmacology | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Physiopathology | en_US |
dc.subject.mesh | Nitric Oxide - Metabolism | en_US |
dc.subject.mesh | Nitroarginine | en_US |
dc.subject.mesh | Oxygen - Administration & Dosage - Pharmacology | en_US |
dc.title | Hypoxic contraction of canine coronary arteries: Role of endothelium and cGMP | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 1661088 | - |
dc.identifier.scopus | eid_2-s2.0-0026322398 | en_US |
dc.identifier.volume | 261 | en_US |
dc.identifier.issue | 6 30-6 | en_US |
dc.identifier.spage | H1769 | en_US |
dc.identifier.epage | H1777 | en_US |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Graser, T=7005581334 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0002-9513 | - |