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Article: Differential actions of platelet-activating factor (PAF) receptor antagonists on the vasodilator and vasoconstrictor effects of PAF in the rat perfused heart

TitleDifferential actions of platelet-activating factor (PAF) receptor antagonists on the vasodilator and vasoconstrictor effects of PAF in the rat perfused heart
Authors
Hu, WMan, RYK
KeywordsPAF antagonists
PAF receptor subtypes
vasoconstriction
vasodilatation
Issue Date1991
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1
Citation
British Journal Of Pharmacology, 1991, v. 104 n. 4, p. 773-775 How to Cite?
DOI: http://dx.doi.org/10.1111/j.1476-5381.1991.tb12504.x
AbstractSelectivity for blocking the coronary vasodilator and vasoconstrictor effects of platelet-activating factor (PAF) in the rat perfused heart was observed with different PAF antagonists. CV-6209 showed selectivity for blocking the vasodilator effect of PAF and a higher concentration (10 fold) was required to block the vasoconstrictor effect. The remaining PAF antagonists (FR-900452, WEB 2086 and BN-50739) showed selectivity for blocking the vasoconstrictor effect of PAF (10, 200 and 1000 fold respectively). A combination of low concentrations of CV-6209 (10 nM) with FR-900452 (5 μM) or WEB 2086 (0.5 μM) was effective in blocking both the vasodilator and vasoconstrictor effects of PAF. CV-6209 and WEB 2086 did not affect the vasodilator action of leukotriene B4 (LTB4) and the vasoconstrictor action of LTC4 and LTD4. Our results support the hypothesis that the functionally opposite effects of PAF in the rat perfused heart may be mediated by different PAF receptor subtypes.
Persistent Identifierhttp://hdl.handle.net/10722/170999
ISSN
0007-1188
2021 Impact Factor: 9.473
2020 SCImago Journal Rankings: 2.432
ISI Accession Number ID
WOS:A1991GT19000002

 

DC FieldValueLanguage
dc.contributor.authorHu, Wen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:11:46Z-
dc.date.available2012-10-30T06:11:46Z-
dc.date.issued1991en_US
dc.identifier.citationBritish Journal Of Pharmacology, 1991, v. 104 n. 4, p. 773-775en_US
dc.identifier.issn0007-1188en_US
dc.identifier.urihttp://hdl.handle.net/10722/170999-
dc.description.abstractSelectivity for blocking the coronary vasodilator and vasoconstrictor effects of platelet-activating factor (PAF) in the rat perfused heart was observed with different PAF antagonists. CV-6209 showed selectivity for blocking the vasodilator effect of PAF and a higher concentration (10 fold) was required to block the vasoconstrictor effect. The remaining PAF antagonists (FR-900452, WEB 2086 and BN-50739) showed selectivity for blocking the vasoconstrictor effect of PAF (10, 200 and 1000 fold respectively). A combination of low concentrations of CV-6209 (10 nM) with FR-900452 (5 μM) or WEB 2086 (0.5 μM) was effective in blocking both the vasodilator and vasoconstrictor effects of PAF. CV-6209 and WEB 2086 did not affect the vasodilator action of leukotriene B4 (LTB4) and the vasoconstrictor action of LTC4 and LTD4. Our results support the hypothesis that the functionally opposite effects of PAF in the rat perfused heart may be mediated by different PAF receptor subtypes.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1en_US
dc.relation.ispartofBritish Journal of Pharmacologyen_US
dc.subjectPAF antagonists-
dc.subjectPAF receptor subtypes-
dc.subjectvasoconstriction-
dc.subjectvasodilatation-
dc.subject.meshAnimalsen_US
dc.subject.meshAzepines - Pharmacologyen_US
dc.subject.meshCoronary Vessels - Drug Effectsen_US
dc.subject.meshHeart - Drug Effectsen_US
dc.subject.meshIndolesen_US
dc.subject.meshPiperazinesen_US
dc.subject.meshPlatelet Activating Factor - Antagonists & Inhibitors - Pharmacologyen_US
dc.subject.meshPlatelet Membrane Glycoproteinsen_US
dc.subject.meshPyridinium Compounds - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshReceptors, Cell Surface - Antagonists & Inhibitorsen_US
dc.subject.meshReceptors, G-Protein-Coupleden_US
dc.subject.meshTriazoles - Pharmacologyen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleDifferential actions of platelet-activating factor (PAF) receptor antagonists on the vasodilator and vasoconstrictor effects of PAF in the rat perfused hearten_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1476-5381.1991.tb12504.x-
dc.identifier.pmid1667284-
dc.identifier.scopuseid_2-s2.0-0025720177en_US
dc.identifier.volume104en_US
dc.identifier.issue4en_US
dc.identifier.spage773en_US
dc.identifier.epage775en_US
dc.identifier.isiWOS:A1991GT19000002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHu, W=7404360099en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US
dc.identifier.issnl0007-1188-

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